Therapeutic Effect of Heterologous Platelet-Rich Plasma on Third-Degree Burn Wound in Rabbits

Abstract

B urns are tissue injuries induced by a heat source, friction, electricity, ionizing radiation, or compounds that destroy the skin's structural integrity (Badis and Omar 2018). Burns predominantly affect the outermost layer of skin and membranes that surround it, but in extreme cases, they can also cause damage to tissues beneath the skin, internal structures, and even death. Mortality and morbidity resulting from burns are typically attributable to second-ary infection and prolonged recovery time (Badade et al., 2016). The intensity of the injury determines the healing response of burns. First-and second-degree burns recover rapidly. However, intensed burn wounds are susceptible to infection and difficult to heal naturally (Sajjad et al., 2018). Burn healing is a complicated sequence of processes including coagulation, inflammation, the formation of granulation tissue, epithelium formation, collagen production, and tissue remodeling (Abegao et al., 2015) and a lack of blood flow, a compromised immune system, and an in-