Therapeutic effect of inhaled budesonide in transient tachypnea of newborn: A placebo-controlled study

Elfarargy, Mohamed Shawky; Abu-Risha, Sally El-Sayed; Younis, Reham Lotfy

doi:10.15586/jptcp.v27i2.663

Cited by 2 publications

(3 citation statements)

References 21 publications

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“…For example, inhaled budesonide has been widely used in neonatal respiratory distress syndrome, but no obvious adverse reactions have been registered. 20 , 21 …”

Section: Discussionmentioning

confidence: 99%

“…For example, inhaled budesonide has been widely used in neonatal respiratory distress syndrome, but no obvious adverse reactions have been registered. 20,21 Zhang et al found that hematologic malignancies and previous cephalosporin administration were associated with the development of CRKP BSI, while mechanical ventilation, septic shock, and CRKP infection were independent mortality predictors for K. pneumoniae associated BSI (Zhang Y et al 2018). 12 Bor M et al found that previous antifungal use, congenital anomalies, and TPN use were found to be independent risk factors for mortality in neonates with CRKP infection.…”

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confidence: 99%

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Risk Factors and Predictive Nomogram for Carbapenem-Resistant Klebsiella pneumoniae in Children in a Grade 3 First-Class General Hospital in Central China

Chu,

Ning,

Fang

et al. 2024

IDR

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Background This study determined risk factors for Carbapenem-resistant Klebsiella pneumoniae (CRKP)in children admitted to a grade 3 first-class general hospital and developed an individualized line graph predictive model. Methods The clinical data of 185 children infected with Klebsiella pneumoniae from January 2015 to December 2019 were analyzed retrospectively. Patients were grouped according to carbapenem resistance: CRKP group (50 cases) and CSKP (carbapenem-sensitive Klebsiella pneumoniae) group (135 cases). Risk factors for CRKP in children were screened by logistic regression analysis. The predictive model was established using R software and validated using the Bootstrap method. Results Age (odds ratio [OR]=0.104, 95% confidence interval [CI]: 0.026–0.408), intensive care unit admission (OR =2.829, 95% CI: 1.138–7.030), mechanical ventilation (OR =7.510, 95% CI: 3.140–17.961), surgery history (OR =5.005, 95% CI: 1.507–16.618) and glucocorticoid (OR =0.235, 95% CI: 0.099–0.557) were independent risk factors for CRKP in children (P < 0.05), The total risk score of each factor was 362.5, and the risk rate was 0.1–0.9. In receiver-operating characteristic curve analysis, the area under the curve of CRKP predicted by the total risk score was 0.872 (95% CI=0.844–0.901; P < 0.001). The correction curve indicated that the consistency between the observed value and the predicted value was good. Discussion and Conclusion This study successfully established a model based on the risk factors, with high accuracy and good predictive value for CRKP in children. Hospitals should take necessary preventive measures against the risk factors for drug-resistant bacteria, such as optimizing the configuration of ICU space, timely isolation of infected children, and adequate disinfection of ICU equipment. Which may reduce CRKP infection rate.

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“…For example, inhaled budesonide has been widely used in neonatal respiratory distress syndrome, but no obvious adverse reactions have been registered. 20 , 21 …”

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Risk Factors and Predictive Nomogram for Carbapenem-Resistant Klebsiella pneumoniae in Children in a Grade 3 First-Class General Hospital in Central China

Chu,

Ning,

Fang

et al. 2024

IDR

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“…Celebi et al 14) have suggested that the prophylactic use of positive pressure ventila tion in the delivery room reduced NICU admission rates. If respi ratory support such as oxygen via a nasal cannula or mechanical ventilation is not provided during an acute illness, respira tory failure may occur because of fatigue and exhaustion of the res piratory muscles 15) . All neonates received supplemental oxy gen therapy to maintain oxygen saturation (≥90%) during hospitali zation.…”

Section: Discussionmentioning

confidence: 99%

Comparative Study on the Clinical Characteristics of Transient Tachypnea of Newborns according to the Need for Invasive Mechanical Ventilation

Yoon,

Lee

2023

Neonatal Med

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Purpose: Transient tachypnea of the newborn (TTN) is the most prevalent respiratory disease worldwide. Many neonates with TTN generally demonstrate spontaneous improvement. However, only few patients present with severe complications. This study aimed to investigate the differences in clinical features to identify neonates at risk for further complications.Methods: Between January 2015 and December 2020, 267 neonates who developed dyspnea within 6 h of birth were delivered at a gestational age of at least 37 weeks. The experimental group (group E) included 44 neonates who required invasive mechanical ventilation, whereas the control group (group C) included 223 neonates who required only observation or non-invasive respiratory support. We analyzed the differences in clinical and perinatal factors between the two groups.Results: Gestational age and pH on arterial blood gas analysis at admission were significantly lower in group E (<i>p</i><0.05). Clinical findings, such as moaning, tachypnea (>90 breaths/min), and pneumothorax, were more frequently observed in group E (<i>p</i><0.05).Conclusion: Moaning, tachypnea (>90 breaths/min), and need for respiratory assistance (fraction of inspired oxygen concentration ≥0.25) are predictive factors for increased risk of progression to a more severe disease course in neonates with TTN. Additional studies are needed to identify definitive factors that can differentiate TTN that improves spontaneously from TTN that requires intensive care.

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Therapeutic effect of inhaled budesonide in transient tachypnea of newborn: A placebo-controlled study

Cited by 2 publications

References 21 publications

Risk Factors and Predictive Nomogram for Carbapenem-Resistant Klebsiella pneumoniae in Children in a Grade 3 First-Class General Hospital in Central China

Risk Factors and Predictive Nomogram for Carbapenem-Resistant Klebsiella pneumoniae in Children in a Grade 3 First-Class General Hospital in Central China

Comparative Study on the Clinical Characteristics of Transient Tachypnea of Newborns according to the Need for Invasive Mechanical Ventilation

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