Therapeutic effect of Momordica balsamina leaf extract on ethanol-induced gastric ulcer in Wistar rats

Mshelia, Hamman Stephen; Karumi, Y; Dibal, Nathan Isaac

doi:10.21037/arh.2017.04.03

Cited by 12 publications

(10 citation statements)

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“…To treat chapped hands, burns and hemorrhoids Liniment Mshelia et al (2017) To treat AIDS Bot et al (2007) abundant in Bryonia, Citrullus, Cucumis, Cucurbita, Echinocystis, Lagenaria, Luffa and Momordica genera (Kaushik et al 2015). Several cucurbitacins have been also isolated from other plant families, including Brassicaceae, Begoniaceae, Rosaceae, Scrophulariaceae and Thymelaeaceae (Kaushik et al 2015;Jing et al 2020).…”

Section: Rootmentioning

confidence: 99%

“…Pre-treatment with extract/ranitidine 1 h before ethanol-induced ulcer. Results accessed 1 h after the administration of ethanol Mshelia et al ( 2017 ) Antidiarrheal activity Methanol fruit extract In vivo Castor oil induced diarrhea in Swiss albino mice. At 800 mg/kg avoid castor oil induced diarrhea by inhibiting intestinal secretion and transit time.…”

Section: Antidiabetic Activitymentioning

confidence: 99%

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Momordica balsamina: phytochemistry and pharmacological potential of a gifted species

et al. 2022

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Momordica balsamina L. (Cucurbitaceae), frequently named balsam apple, southern balsam pear or African pumpkin, is a vegetable with high nutritional value, being mostly used as food in sub-Saharan Africa. It has also been largely used in traditional medicine to treat several diseases, such as malaria fevers and diabetes. As a member of the Cucurbitaceae family, the main constituents are cucurbitane-type triterpenoids, with different oxidation patterns, named cucurbitacins. This review aims at summarizing our contribution to the phytochemical study of M. balsamina and the evaluation of the isolated cucurbitacins and derivatives as multidrug resistance reversers in cancer cells and bacteria. In this way, the selective antiproliferative activity against multidrug resistant cancer cells of cucurbitacins obtained from M. balsamina, their ability as P-glycoprotein inhibitors in cancer cells overexpressing this ABC transporter, as well as efflux pump inhibitors in resistant bacteria strains are reviewed. Moreover, the in vitro antimalarial activity of cucurbitacins and acyl derivatives against the blood and liver-stages of Plasmodium strains, and the in vivo activity of selected compounds is also reviewed. Besides our work, edible and medicinal uses, and other studies mainly reporting the biological activities of M. balsamina extracts, such as antidiabetic, antibacterial, anti-inflammatory, and antioxidant properties are also addressed.

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Section: Rootmentioning

confidence: 99%

Section: Antidiabetic Activitymentioning

confidence: 99%

Momordica balsamina: phytochemistry and pharmacological potential of a gifted species

et al. 2022

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“…All the rats were sacrificed 1 h after 80% ethanol administration using ketamine injection, and the stomachs were cut open, the stomach content were deposited in a beaker, the ulcer index was determined. The gastric content was collected in test tube and centrifuged at 3000 rpm for 10 min, Total acidity (m Eq/L), Gastric acid volume (ml) and pH of the supernatant was measured using digital pH meter 21,22,23 .…”

Section: Experimental Designmentioning

confidence: 99%

GC-MS, FTIR and Antiulcer Screening of Aqueous Seed Extract and Oil of Nigella sativa in Wistar Rats

Bruce

Nwafor

Omoirri

et al. 2021

J. Drug Delivery Ther.

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Peptic ulcer disease (PUD) is a sore in the lining of the stomach or duodenal mucosa. This study was aimed at evaluating the antiulcer activity of the aqueous extract of Nigella sativa (black seed) and its constitutents. The pharmacognostic properties of the dry seeds were determined. The seeds were extracted using two methods digestion and hydro-distillation. The acute toxicity, phytochemical constituents and the antiulcer evaluation were performed on ethanol-induced ulcer in wistar rats using a standard method. FTIR and GC-MS analysis of the aqueous seed extract was also determined using standard methods. Nigella sativa seed shows the presence of starch grains, lignified tissues, tannins, cellulose, protein and oil globules. The aqueous extract has a high safety margin. The phytochemical studies revealed the presence of saponins, flavonoids, alkaloids, tannins, glycosides, fats and oil. The black seed aqueous and oil extract at 500 mg/kg significantly reduced the acidity, total acidity, and ulcer index, and pH of gastric content when compared with the positive control (Famotidine). The FTIR analysis identified the presence of the following functional groups chloro, ether, amine, carboxylic acid, nitriles, methylene, alcohol, while the GC-MS identified five compounds such as glycerin, n-Hexadecanoic acid, 9, 12-octadecadienoic acid-methyl ester, 9, 12-octadecadienoic acid and 9, 12-octadecadienoyl chloride. The pharmacognostic properties can act as a reliable tool for the standardization of the plant part. This study suggests that aqueous and oil extract possess antiulcer properties. Thus the aqueous and oil extract of black seed can be considered as antiulcer medication traditionally. Keywords: Nigella sativa, Black seed, Pharmacognostic, Phytochemical, Acute toxicity (LD50), Antiulcer.

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“…They usually grow as weeds alongside other main food crops and are cheap and easy to harvest [ 2 ]. Despite its nutritional and medicinal importance, there are still gaps in research regarding its nutritional value, especially for the leaves [ 3 ]. In comparison to conventional leafy vegetables, such as spinach, kale, and broccoli, African pumpkin leaves were found to contain higher levels of vitamins, minerals, and antioxidants [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

A Comparison of Bioactive Metabolites, Antinutrients, and Bioactivities of African Pumpkin Leaves (Momordica balsamina L.) Cooked by Different Culinary Techniques

et al. 2022

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Prior to consumption, African pumpkin leaves (Momordica balsamina L.) are generally cooked. In this study, the effects of common household cooking methods (boiling, steaming, microwaving, stir-frying) on bioactive metabolites, carotenoids, antioxidant activity, antinutrients and inhibitory effects on α-glucosidase and α-amylase activities were examined. A set of 14 bioactive metabolites were identified in raw and cooked African leaves using UPLC-QTOF/MS. The results showed that the four different types of household cooking methods had different effects on the bioactive metabolomics profile of African pumpkin leaves. In comparison to raw leaves and leaves cooked in other methods, the concentrations of six phenolic compounds, rutin, cryptochlorogenic acid (4-caffeoylquinic acid), pseudolaroside A, isorhamnetin 3-O-robinoside, quercetin 3-galactoside, and trans-4-feruloylquinic acid, were highest in stir-fried leaves. Of all household cooking methods tested, stir-frying increased the content of lutein, β-carotene, and zeaxanthin by 60.00%, 146.15%, and 123.51%, respectively. Moreover, stir-frying African pumpkin leaves increased the antioxidant activity (DPPH and ABTS) and the inhibition of α-glucosidase and α-amylase. Compared to all four methods of household cooking, stir-frying reduced the antinutritive compounds compared to raw leaves. This work provides useful information to the consumers on the selection of suitable cooking methods for African pumpkin leaves.

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Therapeutic effect of Momordica balsamina leaf extract on ethanol-induced gastric ulcer in Wistar rats

Cited by 12 publications

References 0 publications

Momordica balsamina: phytochemistry and pharmacological potential of a gifted species

Momordica balsamina: phytochemistry and pharmacological potential of a gifted species

GC-MS, FTIR and Antiulcer Screening of Aqueous Seed Extract and Oil of Nigella sativa in Wistar Rats

A Comparison of Bioactive Metabolites, Antinutrients, and Bioactivities of African Pumpkin Leaves (Momordica balsamina L.) Cooked by Different Culinary Techniques

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