Therapeutic Effect of Okra (<i>Abelmoschus esculentus</i> Moench) Pods Extract on Streptozotocin-Induced Type-2 Diabetic Mice

Husen, Saikhu Akhmad; Ansori, Arif Nur Muhammad; Hayaza, Suhailah; Susilo, Raden Joko Kuncoroningrat; Zuraidah, Ayu Aisah; Winarni, Dwi; Punnapayak, Hunsa; Darmanto, Win

doi:10.5958/0974-360x.2019.00633.4

Cited by 59 publications

(39 citation statements)

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“…The therapeutic use of Moringa oleifera leaves has been evaluated in reducing blood glucose because they contain polyphenols such as quercetin-3-glycosides, routine, kaempferol and glycosides. The blood sugar decreased can be noticed in different tests: fasting blood glucose, oral glucose tolerance test, and postprandial glucose in diabetic rats with an average decrease of 25% or more [4,20] . The antidiabetic activity of Moringa oleifera seed powder has been observed in mouse models.…”

Section: Discussionmentioning

confidence: 99%

“…It is called not only effective with low side effects in clinical experience but also relatively spend the low cost. Herbal medicines or extracts are widely prescribed, even when the biologically active compounds are unknown [3,4] . Traditional medicine is generally obtained from natural ingredients [5] .…”

Section: Introductionmentioning

confidence: 99%

“…Flavonoids are one of the most common groups of secondary metabolites found in plant tissues. Flavonoids act as an antioxidants by donating hydrogen atoms or chew metal in the form of glucosides which contain glucose side chains) or aglycones [1,2,3,4] . Extract of Moringa oleifera seed significantly can reduce alloxaninduced hyperglycemia because it contains not only elements like phytochemicals and micronutrient but also quercetin and kaemferol.…”

Section: Introductionmentioning

confidence: 99%

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Analysis of the Moringa oleifera Seed Oil Extract on Insulin Level in Alloxan-Induced Diabetic Rat (Rattus norvegicus)

2020

IJFMT

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Moringa oleifera is a plant that can be used and grown intensively in several Southeast Asian countries. This study aims to determine the effect of Moringa oleifera seed oil extract on the levels of the insulin and blood glucose levels of Rattus norvegicus induced by alloxan. This study used 30 female Wistar white rats induced by alloxan. Rats were divided into 6 groups. Groups 3 to 6 were injected 100, 200, 300, 400 mg/kg BW extract of Moringa oleifera seed oil, respectively. Group 1 neither had alloxan induction nor treatment while group 2 had been induced alloxan but no treatment. Data were analyzed using the Kruskal-Wallis test with a significance level of 0.05. The results showed that there was no effect of Moringa oleifera seed oil extract on insulin level (p value = 0.161). Conversely, there was an effect on blood glucose levels in alloxan-induced Rattus norvegicus (p value = 0.036).

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Analysis of the Moringa oleifera Seed Oil Extract on Insulin Level in Alloxan-Induced Diabetic Rat (Rattus norvegicus)

2020

IJFMT

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“…The administration of lard increase hyperlipidemia and insulin resistance that leads to Type 2 diabetes mellitus which was marked by obesity [30]. Onset of obesity due to the accumulation of excess fat can lead to chronic diseases and complications such as diabetes mellitus and cardiovascular disease [55]. STZ administration is expected to increase the condition of hyperglycemia (increase blood-glucose levels) and created diabetic-like syndrom [29].…”

Section: Discussionmentioning

confidence: 99%

Characterization of Alginate from Sargassum duplicatum and the Antioxidant Effect of Alginate–Okra Fruit Extracts Combination for Wound Healing on Diabetic Mice

et al. 2020

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Diabetes mellitus is a group of metabolic disorders characterized by high blood-glucose levels over a prolonged period that causes complications when an open wound is present. Alginate is an antioxidant and a good absorbent of exudates. Okra fruit contains flavonoids that can act as antioxidants. The antioxidant properties of extracts combination reduce blood-glucose levels significantly to accelerate the activities of wound-healing processes on diabetic mice. Alginate was characterized by Size Exclusion Chromatography-Multiple Angle Laser Light Scattering (SEC-MALLS), thermal stability and Proton Nuclear Magnetic Resonance (1H-NMR). The evaluation of wound healing on 36 male mice were divided into 12 groups including normal control (NC), diabetics control (DC), alginate (DA) and alginate–okra (DAO) groups in three different times by histopathology test on skin tissue. The results of SEC-MALLS analysis showed that alginate as single and homogeneous polysaccharide. The 1H-NMR spectrum showed that the mannuronate/guluronate ratio of the used alginate was 0.91. Alginate, okra fruit extract and their combination were classified as moderate and strong antioxidants. The numbers of fibrocytes, fibroblasts, collagen densities had significantly increased from three to seven days. In contrast, wound width, neutrophil, macrophages had significantly decreased at 14 days. The administration of extracts combination increased the re-epithelization of the wound area and wound-healing process on diabetic mice.

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“…Okra ( Abelmoschus esculentus L.), also known as slime nuts in Indonesia, is a plant that is rich in polysaccharides, vitamin C, and secondary metabolite compounds. The flavonoid compounds in the form of oligomers catechins, quercetin, and vitamin C play role as an antioxidant ( Husen et al., 2019 ; Hayaza et al., 2019a ). Its polysaccharides contain rhamnose and galactose ( Chen et al., 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Dual role of immunomodulation by crude polysaccharide from okra against carcinogenic liver injury in mice

Hayaza

Wahyuningsih

Susilo

et al. 2021

Heliyon

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Polysaccharides have long been recognized as the anticancer agent with low toxicity and slight side effects. Okra (Abelmoschus esculentus L.), a flowering plant from the Malvaceae family that is found in tropical, subtropical, and warm temperate regions around the world. Hence, no in vivo studies have addressed the anticancer and immunomodulatory potential of polysaccharides from okra pods grown in Indonesia. This study aims to investigate the effect of okra raw polysaccharide extract (ORPE) to immune cells and cytokines of mice with hepatocarcinogenic conditions induced by diethylnitrosamine (DEN). Thirty-six male mice (BALB/C, 3-4 months old) were divided into six groups: the normal control group (CN), negative control (C-), positive control giving doxorubicin (Cþ), and three groups of ORPE treatment given the dose of 50 (P1), 100 (P2) and 200 (P3) mg/kg body weight. The administration of ORPE directly suppressed the regulatory T cells accumulations, suppressed macrophages activations, and balanced the number of effector T cells. However, it promoted CD8þ T cell activation at a low dose and increased interleukin-2 levels at all doses. These results suggest that ORPE has unique dual-functions as immunosuppressant and immunostimulant which can be a foundation for the application of the ORPE in the nutraceutical and pharmaceutical industries.

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Therapeutic Effect of Okra (Abelmoschus esculentus Moench) Pods Extract on Streptozotocin-Induced Type-2 Diabetic Mice

Cited by 59 publications

References 0 publications

Analysis of the Moringa oleifera Seed Oil Extract on Insulin Level in Alloxan-Induced Diabetic Rat (Rattus norvegicus)

Analysis of the Moringa oleifera Seed Oil Extract on Insulin Level in Alloxan-Induced Diabetic Rat (Rattus norvegicus)

Characterization of Alginate from Sargassum duplicatum and the Antioxidant Effect of Alginate–Okra Fruit Extracts Combination for Wound Healing on Diabetic Mice

Dual role of immunomodulation by crude polysaccharide from okra against carcinogenic liver injury in mice

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