Therapeutic effect of photodynamic therapy combined with imiquimod in the treatment of anal condyloma acuminatum and its effect on immune function

Meng, Xia; Li, Yongguo; Luan, Hong; Shi, Xiuyan

doi:10.3892/etm.2018.6676

Cited by 3 publications

(5 citation statements)

References 13 publications

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“…Our study demonstrated that thymosin combined with photodynamic therapy effectively reduced the number and area of CA in the anal canal and reduced the adverse reactions caused by drugs, while the tingling, redness, and swelling occurred during the treatment. Related research results show that LTN, SP, and other immune factors are closely related to the occurrence, development, and recurrence of CA [24]. LTN can effectively attract leukocytes to gather in the infected site and participate in the regulation of immune function by activating natural killer cells, T cells, and enhancing mucosal immunity.…”

Section: Discussionmentioning

confidence: 97%

“…Related research results show that LTN, SP, and other immune factors are closely related to the occurrence, development, and recurrence of CA [ 24 ]. LTN can effectively attract leukocytes to gather in the infected site and participate in the regulation of immune function by activating natural killer cells, T cells, and enhancing mucosal immunity.…”

Section: Discussionmentioning

confidence: 99%

“…As a neuropeptide is related to pain transmission, SP participates in immune activities. Related research results show that SP uses G protein-coupled receptors to accelerate the mitosis of infected HPV cells and promote the growth of wart tissue, thus affecting the occurrence and development of CA[ 24 ]. Combined with the results of this study, there was no significant difference in the levels of LTN and SP between the two groups before treatment.…”

Section: Discussionmentioning

confidence: 99%

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A Case-Control Study of Photodynamic Therapy Combined with Thymosin in the Treatment of Condyloma Acuminatum in Anal Canal

Wang

Hong

2022

Journal of Healthcare Engineering

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A case-control study is performed in this paper to explore various possible effects and clinical value of the photodynamic therapy combined with thymosin for the treatment process of the condyloma acuminatum (CA) in the anal canal. For this purpose, a hundred (100) patients specifically with CA in the anal canal who were regularly treated in the hospital from February 2019 to April 2021 were recruited. The first group, that is, the control group, was treated with thymosin, whereas photodynamic therapy combined with thymosin was used as a treatment for the study group. The curative effect, clinical index, LTN, SP, TGF-β 1, TNF-α, CD3+, CD4+, CD8+, and the adverse reactions of incidence were compared between these groups. Moreover, 27 cases were observed to be obviously effective, 22 were observed to be effective, and a single case was observed to be ineffective. Thus, 98% is the total effective rate where a single case relapses. Likewise, in the control group, 15 cases were observed to be obviously effective, 28 effective, and 13 ineffective. Thus, 86% is the total rate of effectiveness where thirteen (13) cases relapse. We have observed that the study group has a higher rate of effectiveness than the control group and the rate of recurrence of the former group was slightly lower than that of the latter group, that is, the control group ( P < 0.05). In addition, the time of symptom improvement, the amount of bleeding, the disappearance time of bloody stool, and the time of the first recurrence of the study group were observed to be lower than those of the control group ( P < 0.05). In levels of LTN and SP, we have observed no or zero significant differences between these groups before treatment. However, LTN’s levels of both groups increased after the treatment, and SP’s level decreased. LTN’s level of the study group was observed to be higher than that of the other group, and SP’s level in the former group was lower than that in the latter group. Zero significant differences were observed in the TGF-β 1 and TNF-α’s levels between these groups before treatment, but the level of TGF-β 1 and TNF-α has increased and decreased, respectively, in both groups specifically after treatment. The level of TGF-β 1 in the former group was observed to be slightly higher than that in the latter group, that is, the control group, while TNF-α’s level in the study group was lower than that in the control group. We have not observed any significant difference in CD4+, CD3+, and CD8+ levels between these groups before treatment. However, after treatment, CD3+ and CD4+ levels increased, and the levels of CD8+ decreased in both groups, while CD3+ and CD4+ levels in the former group were evident to be higher than those in the latter group and the level of the CD8+ in the study group was observed to be lower than that in the control group. Finally, we compared the adverse reactions of incidence between these groups. There were 4 cases of tingling sensation and 1 case of redness and swelling in the group study along with a total incidence of 10%. There were 5 cases of tingling sensation and 2 cases of redness and swelling in the control group along with a total incidence of 14%. The incidence of adverse reactions in the study group was observed to be slightly lower than that in the control group, but a significant difference was not observed between these groups (χ2 = 0.378; P > 0.05).

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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A Case-Control Study of Photodynamic Therapy Combined with Thymosin in the Treatment of Condyloma Acuminatum in Anal Canal

Wang

Hong

2022

Journal of Healthcare Engineering

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“…No glottic synechia was observed following treatment in our cases. In addition to the above-described mechanism of action, ALA-PDT increases CD4+, CD4+/CD8+ and IFN-γ, and reduces CD8+, IL-4, and IL-10 in HPV-infected cells, which may also contribute to the curing of intractable laryngeal papillomatosis ( 21 ).…”

Section: Discussionmentioning

confidence: 99%

Combining aminolaevulinic acid photodynamic therapy with carbon dioxide laser therapy to treat adult-onset laryngeal papillomatosis: case reports and a literature review

Li¹,

Wei²

2021

Transl Cancer Res TCR

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This paper describes 3 cases in which 5-aminolevulinic acid photodynamic therapy (ALA-PDT) was combined with carbon dioxide (CO 2 ) laser therapy to treat patients with adult-onset laryngeal papillomatosis (ALP). Laryngeal papilloma is the most common benign laryngeal tumor, and is usually caused by human papillomavirus (HPV) types 6 and 11. It has the characteristics of rapid growth and frequent recurrence, and has a tendency of malignant transformation. Moreover, it can spread to the lower respiratory tract, which might lead to a rise in mortality risk. Laryngeal papilloma lesions are frequently found on the vocal cords or in the laryngeal cavity, and the characteristic koilocytosis is dispensable in pathological diagnosis of papilloma. Common symptoms include various degrees of hoarseness and wheezing. In the cases reported herein, all 3 patients suffered a recurrence of ALP following treatment. After the removal of the laryngeal papilloma using a combination of ALA-PDT and CO 2 laser therapy, the patients were cured; there was no recurrence, and no further malignant transformation was found in the 6-12 months postoperative follow-up period. Our experiences show that ALA-PDT combined with CO 2 laser therapy is feasible and effective in the treatment of ALP, and produces no obvious adverse reactions. However, further clinical trials need to be undertaken to confirm the efficacy of this treatment.

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“…Clinical studies have shown that the major cause of COPD is immune function disorder that increases the risk of inflammation [13,14]. Immune function is the key to COPD treatment, and T lymphocytes can directly reflect the body's immune function status [53]. e spleen is the Evidence-Based Complementary and Alternative Medicine largest immune organ in the body and contains a large number of lymphocytes.…”

Section: Discussionmentioning

confidence: 99%

Immunomodulatory Effects of Hydrolyzed Seawater Pearl Tablet (HSPT) on Th1/Th2 Functionality in a Mice Model of Chronic Obstructive Pulmonary Disease (COPD) Induced by Cigarette Smoke

Chen

Yan

Zhang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Chronic obstructive pulmonary disease (COPD) is predicted to become the third leading cause of death around the world. The present study is designed to investigate whether hydrolyzed seawater pearl tablet (HSPT) has immunoregulatory effects on the Th1/Th2 functionality in cigarette smoke-induced COPD model mice. The determination of the amino acid composition of HSPT was carried out by high-performance liquid chromatography (HPLC) with precolumn phenylisothiocyanate (PITC) derivatization. COPD model mice were constructed by cigarette smoking (CS) treatment and HSPT was administered. HSPT inhibited the infiltration of inflammation in the airway of the lung, reduced influx of eosinophils (EOSs), lymphocytes (LYMs), neutrophils (NEUs), and macrophages (MACs) in the bronchoalveolar lavage fluid (BALF), decreased the levels of IFN-γ, IL-2, IL-4, and IL-10 in the serum and lung, and decreased the expression of aforementioned cytokines in the spleen and lung in CS-treated mice. Besides, HSPT also had the ability to reduce the amount of CD3+CD4+ T cells and modulate the Th1/Th2 balance. Taken together, this study supports the consensus that CS is a critical factor to induce and aggravate COPD. HSPT could regulate the balance of Th1/Th2 in CS-induced COPD model mice, indicating its effects on inhibiting the development of COPD.

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Therapeutic effect of photodynamic therapy combined with imiquimod in the treatment of anal condyloma acuminatum and its effect on immune function

Cited by 3 publications

References 13 publications

A Case-Control Study of Photodynamic Therapy Combined with Thymosin in the Treatment of Condyloma Acuminatum in Anal Canal

A Case-Control Study of Photodynamic Therapy Combined with Thymosin in the Treatment of Condyloma Acuminatum in Anal Canal

Combining aminolaevulinic acid photodynamic therapy with carbon dioxide laser therapy to treat adult-onset laryngeal papillomatosis: case reports and a literature review

Immunomodulatory Effects of Hydrolyzed Seawater Pearl Tablet (HSPT) on Th1/Th2 Functionality in a Mice Model of Chronic Obstructive Pulmonary Disease (COPD) Induced by Cigarette Smoke

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