Therapeutic effect of quercetin in collagen-induced arthritis

Abstract

Quercetin, a bioactive flavonoid with anti-inflammatory, immunosuppressive, and protective properties, is a potential agent for the treatment of rheumatoid arthritis (RA). Collagen-induced arthritis (CIA) is the most commonly used animal model for studying the pathogenesis of RA. This study analysed the therapeutic role of quercetin in collagen-induced arthritis in C57BL/6 mice. The animals were allocated into five groups that were subjected to the following treatments: negative (untreated) control, positive control (arthritis-induced), arthritis+methotrexate, arthritis+quercetin, and arthritis+methotrexate+quercetin. Assessments of weight, oedema, joint damage, and cytokine production were used to determine the therapeutic effect of quercetin. This study demonstrated for the first time the anti-inflammatory and protective effects of quercetin in vivo in CIA. The results also showed that the concurrent administration of quercetin and methotrexate did not offer greater protection than the administration of a single agent. The use of quercetin as a monotherapeutic agent resulted in the lowest degree of joint inflammation and the highest protection. The reduced severity of the disease in animals treated with quercetin was associated with decreased levels of TNF-α, IL-1β, IL-17, and MCP-1. In conclusion, this study determined that quercetin, which was non-toxic, produced better results than methotrexate for the protection of joints from arthritic inflammation in mice. Quercetin may be an alternative treatment for RA because it modulates the main pathogenic pathways of RA.

Anti-arthritic properties of crude extract from Chenopodium ambrosioides L. leaves

“…[58] The multifaceted therapeutic applications of quercetin on ageing, allergy, angiogenic properties, cancer, inflammation, obesity, arthritis, asthma, diabetes exercise performance, gastroprotection, prostate adenocarcinoma, immunity and infections were extensively reviewed. [59] Therapeutic treatment of CIA with quercetin decreases the severity of arthritic inflammation, protects joints from cartilage and bone damage, [60] and ameliorated all markers of inflammation and oxidative stress measured. [61] It has also been reported that quercetin reduces the production of cytokines, including TNF-a, INF-c and IL-6, [60] which was also observed in this work.…”

“…[59] Therapeutic treatment of CIA with quercetin decreases the severity of arthritic inflammation, protects joints from cartilage and bone damage, [60] and ameliorated all markers of inflammation and oxidative stress measured. [61] It has also been reported that quercetin reduces the production of cytokines, including TNF-a, INF-c and IL-6, [60] which was also observed in this work. Kaempferol, a flavonol also described in the C. ambrosioides extract, showed an antiosteoclastogenic effect [62] and attenuated the severity of arthritis in mice with CIA, which might be associated with its inhibitory effect on the activation of the MAPK signalling pathway.…”

FOXP3 Modulation of Quercetin-3-O-rhamnoside and its Impacts on Lupus Nephritis Mice

“…Quercetin has proven to maintain rheumatoid arthritis in a rat model. 2,13 In this research, we challenged the QUE to treat a severe lupus nephritis mice model and then we measured the biomarkers of T cell dependent pathway of lupus pathogenesis. At the first biomarker, we found an inspiring result in the T reg marker of CD4 + CD25…”

Spremembe vsebnosti rutina in kvercetina v vzorcih tatarske ajde (Fagopyrum tataricum (L.) Gaertn.) od spravila pridelka do priprave kruha / Changes in the content of rutin and quercetin in samples of Tartary buckwheat (Fagopyrum tataricum (L.) (...)

“…Pri podganah so ugotovili, da ima varovalni učinek na kardio-vaskularni sistem (Rendig et al 2001) in da deluje protivnetno (Gardi et al 2015). Kvercetin se je izkazal tudi kot učinkovito sredstvo za zdravljenje revmatoidnega artritisa pri miših (Haleagrahara et al 2017) in je bil učinkovit pri preprečevanju poškodb očesne mrežnice zajcev, ki nastajajo kot posledica svetlobe (Wang et al 2017). Za kvercetin je bilo ugotovljeno, da vzpodbuja delovanje imunskega sistema pri miših (Singh et al 2017).…”