Therapeutic effect of recombinant tissue plasminogen activator on acute cerebral infarction at different times

Abstract

BACKGROUND:The study aimed to compare the therapeutic effect of recombinant tissue plasminogen activator (rt-PA) on the onset of acute cerebral infarction (ACI) at different time points of the first 6 hours.METHODS:A retrospective analysis was conducted in 74 patients who received rt-PA thrombolysis treatment within 4.5 hours after ACI and another 15 patients who received rt-PA thrombolysis treatment between 4.5–6 hours after ACI.RESULTS:National Institute of Health Stroke Scale (NIHSS) scores were statistically decreased in both groups (P>0.05) at 24 hours and 7 days after ACI. There was no significant difference in modified ranking scores and mortality at 90 days after the treatment between the two groups (P>0.05).CONCLUSIONS:The therapeutic effect and mortality of rt-PA treatment in patients with ACI between 4.5–6 hours after the onset of the disease were similar to those in patients who received rt-PA within 4.5 hours after the onset of this disease. Therefore, intravenous thrombolytic therapy for ACI within 4.5–6 hours after ACI was effective and safe.

Risk of Acute Cerebral Infarction and Plasma Asymmetrical Dimethylarginine and Homocysteine Levels: A Clinical Correlation Analysis of Chinese Population

“…2 Various mechanisms involved in the pathogenesis of atherothrombotic stroke include atherosclerotic processes and thrombophilic conditions, which may be linked to L-arginine-nitric oxide (NO) pathway. 3 Endothelial-derived NO, a potent vasodilator, has been reported to play a role as an endogenous anti-atherosclerotic molecule 4 and was synthesized from L-arginine by a family NO synthase.…”

Effect of microbubbles on transcranial doppler ultrasound-assisted intracranial recombinant tissue-type plasminogen activator thrombolysis

“…The rabbits in the rt-PA group received thrombolysis with a dose of 0.9 mg/kg injected intravenously. 16 Recanalization of the embolism following thrombolysis was observed with a 2 MHz ultrasonic probe. The thrombolysis in brain ischemia (TIBI) classification for residual blood flow following cerebral ischemia was used to evaluate the degree of vascular recanalization.…”

Relationship between different surgical methods, hemorrhage position, hemorrhage volume, surgical timing, and treatment outcome of hypertensive intracerebral hemorrhage

“…Currently, directional catheter drainage is thought to have positive clinical effects. [3,18] Especially, directional tube insertion under CT [19][20][21] greatly reduces hematoma and iatrogenic damage, which can be proved by DTI imaging. [22][23][24][25][26][27] Small bone window craniotomy surgery under an operation microscope can timely and effectively remove the brain compression and relieve high intracranial pressure.…”