Therapeutic effect of transplanting HGF-treated bone marrow mesenchymal cells into CCl4-injured rats

Oyagi, Suguru; Hirose, Motohiro; Kojima, Masashi; Okuyama, Makiko; Kawase, Masaya; Nakamura, Toshikazu; Ohgushi, Hajime; Yagi, Kiyohito

doi:10.1016/j.jhep.2005.10.026

Cited by 288 publications

(215 citation statements)

References 28 publications

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“…In addition, in the second model, which induces a more severe liver dysfunction, infusion of MSCs resulted in increased animal survival. Oyagi et al 231 delivered primary-cultured plastic-adherent bone marrow cells to rats before CCl 4 administration and also reported antifibrotic effects. Interestingly, these researchers showed that pre-differentiation of these cells into hepatocytes, by incubation in the presence of HGF, Figure 1 Signaling factors likely involved in chemoattraction and engraftment of MSCs to the injured/remodeled liver.…”

Section: Mscs and Their Anti-fibrotic Potentialmentioning

confidence: 99%

Mesenchymal stem cells as therapeutic tools and gene carriers in liver fibrosis and hepatocellular carcinoma

et al. 2010

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Mesenchymal stem (stromal) cells (MSCs) are a source of circulating progenitors that are able to generate cells of all mesenchymal lineages and to cover cellular demands of injured tissues. The extent of their transdifferentiation plasticity remains controversial. Cells with MSC properties have been obtained from diverse tissues after purification and expansion in vitro. These cellular populations are heterogeneous and under certain conditions show pluripotent-like properties. MSCs present immunosuppressive and anti-inflammatory features and high migratory capacity toward inflamed or remodeling tissues. In this study we review available data regarding factors and signaling axes involved in the chemoattraction and engraftment of MSCs to an injured tissue or to a tissue undergoing active remodeling. Moreover, experimental evidence in support of uses of MSCs as vehicles of therapeutic genes is discussed. Because of its regenerative capacity and its particular immune properties, the liver is a good model to analyze the potential of MSCbased therapies. Finally, the potential application of MSCs and genetically modified MSCs in liver fibrosis and hepatocellular carcinoma (HCC) is proposed in view of available evidence.

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Section: Mscs and Their Anti-fibrotic Potentialmentioning

confidence: 99%

Mesenchymal stem cells as therapeutic tools and gene carriers in liver fibrosis and hepatocellular carcinoma

et al. 2010

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“…This because MSC cultures showed differentiation not only into the same mesodermal-lineage they belong but also into ectodermal-lineage, such as neural and epidermal cells, as well as into endodermal-lineage, such as hepatocytes and b cells. [1][2][3][4][5][6] However, efficiency of differentiation is usually not high, suggesting that this phenomenon is dependent on a small subpopulation. 7 Previously, we identified unique stem cells that we named multilineage-differentiating stress enduring (Muse) cells as one to several percent of the total MSCs of the bone marrow, adipose tissue and dermis.…”

Section: Introductionmentioning

confidence: 99%

The secretome of MUSE cells contains factors that may play a role in regulation of stemness, apoptosis and immunomodulation

et al. 2016

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Mesenchymal stromal cells (MSCs) are a heterogeneous population, which contain several cell phenotypes: mesenchymal stem cells, progenitor cells, fibroblasts and other type of cells. Previously, we identified unique stem cells that we named multilineage-differentiating stress enduring (Muse) cells as one to several percent of MSCs of the bone marrow, adipose tissue and dermis. Among different cell populations in MSCs, Muse cells, positive for pluripotent surface marker SSEA-3, may represent cells responsible for pluripotent-like property of MSCs, since they express pluripotency genes, able to differentiated into triploblastic cells from a single cells and are self-renewable.MSCs release biologically active factors that have profound effects on local cellular dynamics. A thorough examination of MSC secretome seems essential for understanding the physiological functions exerted by these cells in our organism and also for rational cellular therapy design. In this setting, studies on secretome of Muse cells may shed light on pathways that are associated with their specific features.Our findings evidenced that secretomes of MSCs and Muse cells contain factors that regulate extracellular matrix remodeling, ox-redox activities and immune system. Muse cells appear to secrete factors that may preserve their stem cell features, allow survival under stress conditions and may contribute to their immunomodulation capacity.In detail, the proteins belonging to protein kinase A signaling, FXR/RXR activation and LXR/RXR activation pathways may play a role in regulation of Muse stem cell features. These last 2 pathways together with proteins associated with antigen presentation pathway and coagulation system may play a role in immunomodulation.

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“…This fact may suggest the use of some pro-inflammatory, such as tumor necrosis factor (TNF) ␣, in order to upgrade the differentiation ratio. The next two reports show the therapeutic effect of BM-MSCs on liver injury (Oyagi et al, 2006;. Oyagi et al (2006) showed that, after treatment with HGF, transplanting BM-MSCs into a rat with CCl 4 intoxication resulted in improved liver function (albumin and glutamic-oxaloacetic transaminase [GOT] levels) and decreased fibrosis.…”

Section: Bone Marrow Mesenchymal Stem Cells (Bm-mscs)mentioning

confidence: 99%

“…The next two reports show the therapeutic effect of BM-MSCs on liver injury (Oyagi et al, 2006;. Oyagi et al (2006) showed that, after treatment with HGF, transplanting BM-MSCs into a rat with CCl 4 intoxication resulted in improved liver function (albumin and glutamic-oxaloacetic transaminase [GOT] levels) and decreased fibrosis. Similarly, have demonstrated a protective effect of MSCs isolated from rat BM on fibrosis caused by CCl 4 and DMN.…”

Section: Bone Marrow Mesenchymal Stem Cells (Bm-mscs)mentioning

confidence: 99%

Stem cell plasticity: Learning from hepatogenic differentiation strategies

Banas¹,

Yamamoto

Teratani³

et al. 2007

Developmental Dynamics

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Many studies on stem cell plasticity are challenging the concept that stem cells contain an intrinsically predefined, unidirectional differentiation program. This means that the developmental fate of a stem cell is dependent on the general potential of the cell (pre-determined stem cell fate) as well as on microenvironmental cues, such as stimuli from growth factors (stem cell niche). Here, we reviewed reports that examined the hepatocyte differentiation ability of stem cells from two different sources: embryonic stem cells and adult stem cells. All of those stem cells revealed the ability to give rise to hepatocyte-like cells using different induction strategies. However, it is still not clear which of those stem cells would be the best source for hepatocyte replacement or which would be the best protocol. We herein present the current knowledge regarding available protocols and factors used in order to obtain functional hepatocytes from stem cells. Developmental Dynamics 236:3228 -3241, 2007.

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Therapeutic effect of transplanting HGF-treated bone marrow mesenchymal cells into CCl4-injured rats

Cited by 288 publications

References 28 publications

Mesenchymal stem cells as therapeutic tools and gene carriers in liver fibrosis and hepatocellular carcinoma

Mesenchymal stem cells as therapeutic tools and gene carriers in liver fibrosis and hepatocellular carcinoma

The secretome of MUSE cells contains factors that may play a role in regulation of stemness, apoptosis and immunomodulation

Stem cell plasticity: Learning from hepatogenic differentiation strategies

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