Therapeutic effect of umbelliferon-α-D-glucopyranosyl-(2I→1II)-α-D-glucopyranoside on adjuvant-induced arthritic rats

Abstract

The aim and objective of the present investigation was to evaluate the antiarthritic and antioxidant effect of umbelliferon-α-D-glucopyranosyl-(2I→1II)-α-D-glucopyranoside (UFD) in chemically induced arthritic rats. The different doses of the UFD were tested against the turpentine oil (TO), formaldehyde induced acute arthritis and complete fruend's adjuvant (CFA) induced chronic arthritis in Wistar rats. Arthritic assessment and body weight was measured at regular interval till 28 days. On day 28, all the groups animals were anaesthetized, blood were collected from the puncturing the ratro orbital and estimated the hematological parameters. The animals were sacrificed; synovial tissue was extracted and estimated the malonaldehyde (MDA), glutathione (GSH), glutathione peroxidase (GPx) and superoxide dismutase (SOD). The different doses of the UFD showed the protective effect against turpentine oil, formaldehyde induced acute arthritis and CFA induced chronic arthritis at dose dependent manner. Acute model of arthritis such as TOand formaldehyde induced inflammation due to releasing of the inflammatory mediators; significantly inhibited by the UFD at dose dependent manner. CFA induced arthritic rats treated with the different doses of the UFD showed the inhibitory effect on the delayed increase in joint diameter as seen in arthritic control group rats. UFD significantly improved the arthritic index, body weight and confirmed the antiarthritic effect. UFD showed the effect on the hematological parameter such as improved the level of the RBC, Hb and decline the level of the EBC, ESR and confirmed the immune suppressive effect. UFD significantly improved the level of the endogenous antioxidant and confirmed the antioxidant effect. This present investigation suggests that the UFD has prominent antiarthritic impact which can be endorsed to its antiarthritic and antioxidant effects.

Umbelliferone β-d-galactopyranoside inhibits chemically induced renal carcinogenesis via alteration of oxidative stress, hyperproliferation and inflammation: possible role of NF-κB

“…[49][50] DEN+Fe-NTA induced rats treated with UFG considerably altered the histopathology changes of renal due to its antioxidant and antiinflammatory potential as previously reported. 16,19,51 ODC is a rate limiting enzyme use in polyamine biosynthesis and provoke the large number of tumor promoters. Thymidine and ODC incorporation are extensively used as the biochemical marker for assessment of tumor expansion and hyperproliferative agents.…”

Deconvoluting the dual hypoglycemic effect of wedelolactone isolated fromWedelia calendulacea: investigationviaexperimental validation and molecular docking

“…Group I: normal and treated with saline only (1 ml kg À1 per day) for 28 The rats received the above-discussed treatment for 28 days. The body weight and food intake were monitored at regular intervals.…”

“…The hepatic parameters, namely alkaline phosphatase (AST), aspartate aminotransferase (AST), alanine transaminase (ALT); serum renal parameters, including blood urea nitrogen (BUN), total protein, creatinine, albumin; lipid parameters, such as total cholesterol (TC), high density lipoprotein (HDL), triglyceride (TG), very low density lipoprotein (VLDL) and, low density lipoprotein (LDL), were scrutinized using commercially available diagnostic kits. The atherogenic index and coronary risk index were scrutinized as per the given formula: [24][25][26][27][28][29][30][31] Inammatory and pro-inammatory mediators Pro-inammatory cytokines, namely interleukin-6 (IL-6), tumor necrosis factor-a (TNF-a), and inammatory mediators, such as C-reactive protein (CRP), were also estimated as per the instructions in the available commercial kits.…”

Fabrication, optimization, and characterization of umbelliferone β-D-galactopyranoside-loaded PLGA nanoparticles in treatment of hepatocellular carcinoma: in vitro and in vivo studies

“…The hematological parameters such as red blood cells (RBC), erythrocytes sedimentation rate (ESR), white blood cells (WBC), and hemoglobin (Hb) were estimated using the method reported by Kumar et al 15,16 antioxidant parameters Antioxidant parameters were estimated from liver homogenates such as catalase (CAT), lipid peroxidation (LPO), superoxide dismutase (SOD), glutathione transferase (GST), glucose 6-phosphate dehydrogenase, conjugated dienes (CD), and glutathione peroxidase (GPx) by standard methods.…”