Therapeutic effect of ustekinumab on patients with extra-intestinal manifestations of Crohn’s disease

Lu, Shilin; Yao, Jiayin; Mao, Zhi

doi:10.1080/17474124.2023.2189096

Expert Review of Gastroenterology & Hepatology

2023

DOI: 10.1080/17474124.2023.2189096

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Therapeutic effect of ustekinumab on patients with extra-intestinal manifestations of Crohn’s disease

Shilin Lu

Jiayin Yao

Zhi Mao

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2024

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Cited by 2 publications

References 41 publications

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Morphological and regional spontaneous functional aberrations in the brain associated with Crohn’s disease: a systematic review and coordinate-based meta-analyses

Kong,

Zhou,

Zhang

et al. 2024

Cerebral Cortex

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Crohn's disease is an acknowledged “brain–gut” disorder with unclear physiopathology. This study aims to identify potential neuroimaging biomarkers of Crohn's disease. Gray matter volume, cortical thickness, amplitude of low-frequency fluctuations, and regional homogeneity were selected as indices of interest and subjected to analyses using both activation likelihood estimation and seed-based d mapping with permutation of subject images. In comparison to healthy controls, Crohn's disease patients in remission exhibited decreased gray matter volume in the medial frontal gyrus and concurrently increased regional homogeneity. Furthermore, gray matter volume reduction in the medial superior frontal gyrus and anterior cingulate/paracingulate gyri, decreased regional homogeneity in the median cingulate/paracingulate gyri, superior frontal gyrus, paracentral lobule, and insula were observed. The gray matter changes of medial frontal gyrus were confirmed through both methods: decreased gray matter volume of medial frontal gyrus and medial superior frontal gyrus were identified by activation likelihood estimation and seed-based d mapping with permutation of subject images, respectively. The meta-regression analyses showed a positive correlation between regional homogeneity alterations and patient age in the supplementary motor area and a negative correlation between gray matter volume changes and patients’ anxiety scores in the medial superior frontal gyrus. These anomalies may be associated with clinical manifestations including abdominal pain, psychiatric disorders, and possibly reflective of compensatory mechanisms.

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Morphological and regional spontaneous functional aberrations in the brain associated with Crohn’s disease: a systematic review and coordinate-based meta-analyses

Kong,

Zhou,

Zhang

et al. 2024

Cerebral Cortex

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Metabolic Dysfunction-Associated Steatotic Liver Disease in Patients with Inflammatory Bowel Diseases: A Pilot Study

Abenavoli,

Spagnuolo,

Scarlata

et al. 2024

Life

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Background: Inflammatory bowel disease (IBD) is characterized by persistent inflammation and is often associated with metabolic dysfunction-associated steatotic liver disease (MASLD). IBD patients are at risk of developing MASLD due to shared risk factors such as gut dysbiosis and systemic inflammation. The new MASLD nomenclature emphasizes the link between liver steatosis and cardiometabolic comorbidities. However, the prevalence of MASLD in IBD patients remains poorly explored. The main aim of this cross-sectional study is to assess the prevalence of ultrasound (US) and the clinical features of MASLD in patients with IBDs. Materials and Methods: We conducted a retrospective study enrolling 272 Italian IBD patients attending Renato Dulbecco Teaching Hospital in a period between 1 January 2021 and 31 December 2023. MASLD was diagnosed based on the presence of liver steatosis with cardiometabolic risk factors, using established guidelines. Demographic, clinical, and laboratory data were collected and analyzed. Statistical significance was determined at a p-value < 0.05. Results: Of the 272 IBD patients, 6% had non-alcoholic fatty liver disease (NAFLD), while 18% had MASLD. Patients with IBD-MASLD were significantly older, had higher body mass index, waist circumference, and triglyceride levels, and were more likely to have type 2 diabetes mellitus and hypertension compared to those with IBD-NAFLD. IBD-MASLD patients also showed higher disease activity scores and required more frequent surgical interventions. Bivariate logistic regression revealed triglyceride levels as a significant predictor of MASLD in IBD patients. Conclusions: MASLD is more prevalent in IBD patients, highlighting the importance of early detection of liver steatosis in this at-risk population. The association between MASLD and cardiometabolic risk factors underscores the need for a multidisciplinary approach to manage these patients effectively. Further studies in larger cohorts are necessary to confirm these findings and explore the pathophysiological mechanisms involved.

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Therapeutic effect of ustekinumab on patients with extra-intestinal manifestations of Crohn’s disease

Cited by 2 publications

References 41 publications

Morphological and regional spontaneous functional aberrations in the brain associated with Crohn’s disease: a systematic review and coordinate-based meta-analyses

Morphological and regional spontaneous functional aberrations in the brain associated with Crohn’s disease: a systematic review and coordinate-based meta-analyses

Metabolic Dysfunction-Associated Steatotic Liver Disease in Patients with Inflammatory Bowel Diseases: A Pilot Study

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