Therapeutic effectiveness of phytochemicals targeting specific cancer cells: a review of the evidence

Ravi, Pooja; Isaq, Mona; Ramachandra, Yarappa Lakshmikant; Somu, Prathap; Padmalatha, S.; Poojari, Chandrappa Chinna; Anand, Kumar Hegde Biliyaru; Shilali, K.; Shabbirahmed, Asma Musfira; Kumaravel, Mohanya

doi:10.1016/b978-0-443-19143-5.00039-6

Cited by 3 publications

(1 citation statement)

References 54 publications

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“…For centuries, natural medications derived from plants have been utilized to treat a variety of serious illnesses. The active isolation and extraction of cytotoxic podophyllotoxins, such as vinca alkaloids such as vincristine and vinblastine, began in the 1950s (1) .The production of pharmaceuticals from medicinal plants or trees, on the other hand, poses major challenges. For instance, approximately 38,000 yew trees need to be harvested to isolate 25 kg of the anti-cancer drug taxol, enough to treat 12,000 patients (2) .…”

Section: Introductionmentioning

confidence: 99%

Statistical Optimization for the Production of Antimicrobial Compounds Produced by Mangrove Endophytic Aspergillus sp.

Trivedi¹,

Thumar²

2023

IJST

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Objectives:The purpose of this study was to investigate the antibacterial properties of an endophytic fungus, Aspergillus sp., isolated from the roots of the Avicennia marina belonging to an unexplored location in Kutch, Gujarat, India. The study aimed to optimize various factors to enhance the production of antimicrobial compounds. Methodology: Antimicrobial activity was performed using the agar-well diffusion method, and the results were compared with the standard antibiotic streptomycin as a positive control and DMSO as a negative control. The classical one-factor-at-a-time (OFT) approach was used to optimize various factors such as temperature, pH, culture media, carbon and nitrogen sources, and solvents to enhance antimicrobial production. Response Surface Methodology (RSM) was used to statistically optimize the production of antimicrobial compounds. Findings: The investigation revealed that the endophyte exhibited remarkable inhibitory action against sensitive strains of Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, Bacillus cereus, and Staphylococcus aureus. The most suitable conditions for the production of antimicrobials were; an inoculum size of 1*10 5 in potato dextrose medium at a temperature of 25 • C and pH 6, with an incubation period of 12 days. Starch and ammonium chloride acted as the best carbon and nitrogen sources, respectively. The use of RSM resulted in a 1.46-fold increase in the antimicrobial activity against Pseudomonas sp., with an increase in the zone of inhibition from 18.36mm to 26.8mm. Novelty: The study highlights the unique antimicrobial potential of an unexplored endophyte derived from Avicennia marina roots in Kutch, Gujarat, India. RSM played a crucial role in detecting optimum conditions for the production of antimicrobial compounds, resulting in a significant increase in activity. Its application emphasizes the importance of advanced statistical techniques in improving our understanding of complex biological systems.

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Section: Introductionmentioning

confidence: 99%

Statistical Optimization for the Production of Antimicrobial Compounds Produced by Mangrove Endophytic Aspergillus sp.

Trivedi¹,

Thumar²

2023

IJST

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Targeting the breast tumor microenvironment by plant-derived products and their nanoformulations

Zhang,

2024

Journal of Drug Delivery Science and Technology

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Therapeutic Perspective of Natural Alkaloids in Cervical Cancer Management

Jadhao,

Parveen,

Yusuf

2024

Jabirian J. Biointerface Res. Pharmaceut. Appl. Chem.

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Cervical cancer is a major global public health concern that requires continuous advancements in screening methodologies and the management of associated challenges. This will make cervical cancer a preventable and treatable condition for women across the world. In this review, we explore the therapeutic potential of natural alkaloids in managing cervical cancer. These compounds are derived from diverse sources such as plants and marine organisms. They demonstrate multifaceted mechanisms, including anti-proliferative, anti-angiogenic, and immunomodulatory effects. Preclinical studies have shown their efficacy on cervical cancer cell lines, while clinical trials have showcased their potential inpatient interventions. To enhance their efficacy, synergistic approaches combining alkaloids with conventional treatments are being considered. Despite challenges such as bioavailability and toxicity, continued research is vital to unlocking the full potential of natural alkaloids. This will offer novel and complementary strategies in cervical cancer therapeutics.

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Therapeutic effectiveness of phytochemicals targeting specific cancer cells: a review of the evidence

Cited by 3 publications

References 54 publications

Statistical Optimization for the Production of Antimicrobial Compounds Produced by Mangrove Endophytic Aspergillus sp.

Statistical Optimization for the Production of Antimicrobial Compounds Produced by Mangrove Endophytic Aspergillus sp.

Targeting the breast tumor microenvironment by plant-derived products and their nanoformulations

Therapeutic Perspective of Natural Alkaloids in Cervical Cancer Management

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