Therapeutic Effects and Mechanisms of Herbal Medicines for Treating Polycystic Ovary Syndrome: A Review

Kwon, Chan-Young; Cho, Ik‐Hyun; Park, Kyoung Sun

doi:10.3389/fphar.2020.01192

Cited by 26 publications

(14 citation statements)

References 76 publications

(146 reference statements)

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“…Traditional Chinese medicine is widely used in the clinical treatment of PCOS. Studies have shown that Chinese herbal medicine has significant efficacy in promoting hormone normalization, estrus cycle recovery, insulin resistance and lipid metabolism improvement in patients with PCOS ( 24 ). The Bu Shen Yang Xue formula (BSYXF) is a traditional Chinese medicine compound, which is composed of 15 g of Rehmannia glutinosa (Gaertn.)…”

Section: Introductionmentioning

confidence: 99%

β-Sitosterol Ameliorates Endometrium Receptivity in PCOS-Like Mice: The Mediation of Gut Microbiota

Cao

Huang

et al. 2021

Front. Nutr.

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Background: Polycystic ovary syndrome (PCOS), one of the most common endocrine diseases in women of childbearing age, has been found to be accompanied by changes in the gut microbiota. The Bu Shen Yang Xue formula (BSYXF) is a traditional Chinese medicine widely used for the treatment of PCOS. This study aimed to investigate whether the protective effects of β-sitosterol, the main active ingredient of BSYXF, on PCOS was mediated by regulating gut microbiota.Methods: The presence of β-sitosterol in BSYXF was detected by liquid chromatography-mass spectrometry. The PCOS-like mouse model was induced by dehydroepiandrosterone. The fecal supernatant of β-sitosterol-treated mice was prepared for fecal microbiota transplantation (FMT). Body weight and wet weight of the uterus and ovary of the mice were recorded for organ index calculation. Hematoxylin and eosin stain was used to assess the endometrial morphology and microenvironment changes. Expression of endometrial receptivity markers cyclooxygenase-2 (COX-2), Integrin ανβ3, leukemia inhibitory factor (LIF), and homeobox A10 (HOXA10) in the endometrium were determined by immunohistochemistry and western blot analysis. Enzyme-linked immunosorbent assay was employed to detect the expression of follicle stimulating hormone (FSH), luteinizing hormone (LH), progesterone (P), and testosterone (T) in the serum. The diversity of gut microbiota was examined by 16S rDNA gene sequencing.Results: With the treatment of β-sitosterol and β-sitosterol-FMT, the uterine index of PCOS-like mice increased, the ovarian index decreased, levels of COX-2, LH and T decreased, and levels of Integrin ανβ3, LIF, HOXA10, FSH, and P increased. Under β-sitosterol treatment, the structure of the gut microbiota in PCOS-like mice was also changed.Conclusion: β-sitosterol regulates the endometrial receptivity of PCOS and harmonizes the sex hormone balance, which may be related to the changes in the structure and composition of gut microbiota, thus affecting the pathological process of PCOS.

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Section: Introductionmentioning

confidence: 99%

β-Sitosterol Ameliorates Endometrium Receptivity in PCOS-Like Mice: The Mediation of Gut Microbiota

Cao

Huang

et al. 2021

Front. Nutr.

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“…At present, no perfect treatment is available for the PCOS symptoms. Therefore, herbal plants bearing active compounds are practical alternatives to available drugs and have attracted much attention in recent years [70]. The treatment of PCOS women with M. spicata (spearmint) tea twice a day exhibited a positive effect and decreased the level of free and total testosterone, increased the FSH and LH level, and subsequently decreased the hirsutism.…”

Section: Herbal Plants In Pcos Treatmentmentioning

confidence: 99%

Recent Approaches in the Treatment of Polycystic Ovary Syndrome: An Update

2022

ARCH Women Health Care

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the male hormone androgen in females. It is one of the main reasons for PCOS's clinical complications, including anovulation, abnormal menstrual cycle, and infertility. Furthermore, hyperandrogenism can initiate hirsutism, acne, androgenic alopecia, and metabolic abnormalities such as obesity, insulin resistance, hyperinsulinemia, and dyslipidemia. In many PCOS women, lipid abnormalities, exceptionally high triglyceride, low high-density lipoprotein cholesterol levels, and impaired fibrinolysis have been observed.PCOS and associated complications physically affect the female body, and the complicated connection between genetics, environment, and hormones instigates mental health problems [4]. Reports suggest

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“…The pathophysiology of PCOS has not been fully clarified, and currently, only symptomatic treatments have been administered to patients with PCOS [ 33 , 34 ]. Numerous herbal remedies have been tested on women with PCOS and PCOS-induced animal models [ 35 , 36 , 37 ]. These remedies include green tea, welsh onion root and Chinese herbal medicine [ 38 , 39 , 40 ].…”

Section: Effect Of Curcumin On Polycystic Ovary Syndrome (Pcos)mentioning

confidence: 99%

Potential Health Benefits of Curcumin on Female Reproductive Disorders: A Review

et al. 2021

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Curcumin is one of the main polyphenolic compounds in the turmeric rhizome. It possesses antioxidant, anti-inflammatory, anti-cancer, anti-arthritis, anti-asthmatic, anti-microbial, anti-viral and anti-fungal properties. This review aims to provide an overview of the potential health benefits of curcumin to treat female reproductive disorders, including polycystic ovary syndrome (PCOS), ovarian failure and endometriosis. Comprehensive information on curcumin was retrieved from electronic databases, which were MEDLINE via EBSCOhost, Scopus and Google Scholar. The available evidence showed that curcumin reduced the high level of androgen in PCOS. Studies in rodents suggest that curcumin resulted in the disappearance of cysts and the appearance of healthy follicles and corpora lutea. Furthermore, animal studies showed curcumin improved the overall function of the ovary in ovarian diseases and reversed the disturbance in oxidative stress parameters. Meanwhile, in vitro and in vivo studies reported the positive effects of curcumin in alleviating endometriosis through anti-inflammatory, anti-proliferative, anti-angiogenic and pro-apoptotic mechanisms. Thus, curcumin possesses various effects on PCOS, ovarian diseases and endometriosis. Some studies found considerable therapeutic effects, whereas others found no effect. However, none of the investigations found curcumin to be harmful. Curcumin clinical trials in endometriosis and ovarian illness are still scarce; thus, future studies need to be conducted to confirm the safety and efficacy of curcumin before it could be offered as a complementary therapy agent.

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Therapeutic Effects and Mechanisms of Herbal Medicines for Treating Polycystic Ovary Syndrome: A Review

Cited by 26 publications

References 76 publications

β-Sitosterol Ameliorates Endometrium Receptivity in PCOS-Like Mice: The Mediation of Gut Microbiota

β-Sitosterol Ameliorates Endometrium Receptivity in PCOS-Like Mice: The Mediation of Gut Microbiota

Recent Approaches in the Treatment of Polycystic Ovary Syndrome: An Update

Potential Health Benefits of Curcumin on Female Reproductive Disorders: A Review

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