Therapeutic effects and mechanisms of actions of <i>Descurainia sophia</i>

Hsieh, Po‐Chun; Kuo, Chan‐Yen; Lee, Yen‐Hsien; Wu, Yao‐Kuang; Yang, Mei‐Chen; Tzeng, I‐Shiang; Cui, Lan

doi:10.7150/ijms.47357

Cited by 16 publications

(8 citation statements)

References 24 publications

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“…Overall, the results revealed that AEDS is involved in the regulation of mitochondrial function and shows relative protective effects on MtMP during LPS stimulation. Various components of AEDS may affect the mitochondrial function via multiple pathways (14).…”

Section: Discussionmentioning

confidence: 99%

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Aqueous Extract of Descuraniae Semen Attenuates Lipopolysaccharide-Induced Inflammation and Apoptosis by Regulating the Proteasomal Degradation and IRE1α-Dependent Unfolded Protein Response in A549 Cells

Hsieh

Peng²,

Liu³

et al. 2022

Front. Immunol.

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BackgroundLipopolysaccharide (LPS)-induced acute lung injury (ALI) induces endoplasmic reticulum stress, unfolded protein response (UPR), apoptosis, and inflammation. Inositol-requiring enzyme 1 (IRE1)-α is important for adaptive and apoptotic UPR determination during ER stress. The aqueous extract of Descuraniae Semen (AEDS) is reported to be a safe and effective herb for the treatment of pulmonary edema as it shows anti-inflammatory activities.MethodsWe investigated the effects of AEDS on LPS-induced ALI in A549 cells with respect to the regulation of IRE1α-dependent UPR, proteasomal degradation, mitochondrial membrane potential (MtMP), inflammation, and apoptosis.ResultsAEDS attenuated ER stress by regulating the proteasomal degradation. LPS induced ER stress [binding immunoglobulin protein (BiP), phosphorylated IRE1α, sliced X-box binding protein 1 [XBP1s], phosphorylated cJUN NH2-terminal kinase (pJNK), B-cell lymphoma (Bcl)-2-associated X (Bax), Bcl-2], inflammation (nucleus factor-kappa B (NF-κB) p65 nuclear translocation, nucleus NF-κB, pro-inflammatory cytokines] and apoptosis [C/EBP homologous protein (CHOP), cytochrome c, caspase-8, and caspase-6, and TUNEL] were significantly attenuated by AEDS treatment in A549 cells. AEDS prevents LPS-induced decreased expression of MtMP in A549 cells.ConclusionsAEDS attenuated LPS-induced inflammation and apoptosis by regulating proteasomal degradation, promoting IRE1α-dependent adaptive UPR, and inhibiting IRE1α-dependent apoptotic UPR. Moreover, IRE1α-dependent UPR plays a pivotal role in the mechanisms of LPS-induced ALI. Based on these findings, AEDS is suggested as a potential therapeutic option for treating patients with ALI.

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Section: Discussionmentioning

confidence: 99%

“…Descuraniae Semen (DS) is the dried seed of Descurainia sophia L. Webb ex Prantl (13). DS is an effective and safe herb that is used in complementary and alternative medicine for the treatment of cough, asthma, and pulmonary edema (14). In clinical practice, DS is used as the aqueous extract of DS (AEDS).…”

Section: Introductionmentioning

confidence: 99%

Aqueous Extract of Descuraniae Semen Attenuates Lipopolysaccharide-Induced Inflammation and Apoptosis by Regulating the Proteasomal Degradation and IRE1α-Dependent Unfolded Protein Response in A549 Cells

Hsieh

Peng²,

Liu³

et al. 2022

Front. Immunol.

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“…The anti-inflammatory and antioxidant effects of DS have been proven in previous experimental studies [ 24 , 33 ]. Mirzaei et al showed antioxidant effects of this herb in vitro [ 21 ].…”

Section: Introductionmentioning

confidence: 94%

Effects of Descurainia sophia on Oxidative Stress Markers and Thirst Alleviation in Hemodialysis Patients: A Randomized Double-Blinded Placebo-Controlled Cross-Over Clinical Trial

Asgharpour

Enayati

Sadrabadi

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background. Patients undergoing hemodialysis (HD) are regularly exposed to oxidative stress and inflammation and may suffer from thirst distress with no definitive treatment to address these complications. Descurainia sophia (DS) has been used to alleviate thirst in traditional Persian medicine. This study aimed to assess the effectiveness of DS on oxidation factors and thirst score in HD patients. Methods. This study was conducted on fifty-three HD patients referred to Tehran Shahid Modarres hospital. The patients were randomly divided into two groups: Group 1 received DS for six weeks, then underwent four weeks of washout period followed by six weeks of placebo treatment, while group 2 received placebo initially followed by treatment with DS. Biochemistry, malondialdehyde (MDA), and total antioxidant capacity (TAC) were measured in four phases: at the beginning, before washout, after washout, and at the end of the study. The patient’s body weight was recorded at the start of each session to assess interdialytic weight gain. Thirst scores also were measured using a visual analog scale. Results. A total of 53 patients, including 23 (43.4%) male and 30 (56.6%) female subjects, were included in the study. The results showed a reduction in thirst score ( p = 0.001 ), cholesterol levels ( p = 0.046 ), triglycerides (0.003), and MDA ( p < 0.001 ) following the four-week administration of DS treatment in HD patients. The mean levels of TAC were increased ( p < 0.001 ), and calcium, as well as Na+, remained unchanged ( p > 0.05 ). Also, a significant decrease in the patient’s weight was observed ( p value <0.001). This effect persisted after shifting to a placebo. However, the two groups had no significant difference ( p value = 0.539). Conclusion. DS powder-mixed syrup may benefit HD patients by facilitating free radical scavenging and alleviating thirst distress with minimal adverse effects. The seeds could therefore be utilized as a complementary therapy for hemodialysis patients.

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“…One of the compounds in the seeds, allyl disulfide, may have a relaxing effect on smooth muscles and facilitate defecation. (112) RoB: high Minimal evidence that suggests it may be just as effective as PEG treatment, but with worse taste. (62) Xiao'er Biantong granules Xiao'er Biantong granules are a Chinese patent medicine composed of 7 herbs.…”

Section: Cassia Fistulamentioning

confidence: 99%

Nonpharmacologic Treatment for Children with Functional Constipation: A Systematic Review and Meta-analysis

Wegh

Baaleman

Tabbers

et al. 2022

The Journal of Pediatrics

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Therapeutic effects and mechanisms of actions of Descurainia sophia

Cited by 16 publications

References 24 publications

Aqueous Extract of Descuraniae Semen Attenuates Lipopolysaccharide-Induced Inflammation and Apoptosis by Regulating the Proteasomal Degradation and IRE1α-Dependent Unfolded Protein Response in A549 Cells

Aqueous Extract of Descuraniae Semen Attenuates Lipopolysaccharide-Induced Inflammation and Apoptosis by Regulating the Proteasomal Degradation and IRE1α-Dependent Unfolded Protein Response in A549 Cells

Effects of Descurainia sophia on Oxidative Stress Markers and Thirst Alleviation in Hemodialysis Patients: A Randomized Double-Blinded Placebo-Controlled Cross-Over Clinical Trial

Nonpharmacologic Treatment for Children with Functional Constipation: A Systematic Review and Meta-analysis

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