Therapeutic effects of 10-HzPulsed wave lasers in rat depression model: A comparison between near-infrared and red wavelengths

Salehpour, Farzad; Rasta, Seyed Hossein; Mohaddes, Gisou; Sadigh-Eteghad, Saeed; Salarirad, Sima

doi:10.1002/lsm.22542

Cited by 47 publications

(39 citation statements)

References 80 publications

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“…Serum cortisol levels were significantly increased in mice underwent to CRS procedure that confirms the results of a previous depression study [31]. The effect of NIR (810 nm, 10 Hz) TPBM on cortisol levels in CMS rat model was examined by Salehpour et al [20] and no significant changes were observed in cortisol concentrations after TPBM. Probably, the delivered dose to the PFC (about 1.2 J/cm 2 ) was not sufficient to make a therapeutic effect.…”

Section: Discussionsupporting

confidence: 80%

“…These results are parallel to the prior depression studies [27,28]. In a study by Salehpour et al [20] the anti-anxiety effect of NIR (810 nm, 10 Hz) TPBM in CMS rat was evaluated by EPM test. In their study, a NIR dose of 1.2 J/cm 2 was delivered to the PFC and non-significant improvements in the both %OAE and %OAT variables were observed.…”

Section: Discussionsupporting

confidence: 79%

“…In another study, Ando et al observed an anti‐depressive effect of pulsed NIR laser (810 nm, 10 Hz) at dose of 36 J/cm 2 , on the scalp, in traumatic brain injury mice by TST. It should be noted that in former studies, delivering NIR doses of 1.2 J/cm 2 to the PFC and 1.8 J/cm 2 to the cortical surface of CMS rat per session caused significant anti‐depressive effects in the force swimming test (FST). In comparison, in this study, a higher delivered NIR dose of 4 J/cm 2 to the cerebral surface of CRS mice per session did not make a significant anti‐depressive effect in the TST.…”

Section: Discussionmentioning

confidence: 99%

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Transcranial photobiomodulation prevents anxiety and depression via changing serotonin and nitric oxide levels in brain of depression model mice: A study of three different doses of 810 nm laser

et al. 2019

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Objectives The effectiveness of transcranial photobiomodulation (TPBM) in treating anxiety and depression disorders is a demonstrated and identified issue. However, the optimum therapeutic dose and the underlying mechanism of action are not fully understood. In this study, the therapeutic effects of three different near‐infrared (NIR) doses on anxiety‐ and depression‐like behaviors as well as cerebral levels of serotonin (5‐HT) and nitric oxide (NO) were evaluated in a mouse model of chronic restraint stress (CRS). Materials and Methods CRS procedure (3 hours/day, over 3 weeks) was performed as a typical stress model to study anxiety and depression along with laser treatment (3 times/week, over 3 weeks), which began simultaneously with CRS. A NIR diode laser (810 nm wavelength, 10 Hz) with the output power of 200 mW and power density of 4.75 W/cm2 was implemented to deliver three different doses of 4, 8, and 16 J/cm2 to the cerebral cortex of mice. Behavioral experiments including open field, tail suspension, and elevated plus maze tests as well as serum cortisol levels were assessed to evaluate the anti‐anxiety and anti‐depressive effects of NIR TPBM. The changes of 5‐HT and NO levels in the prefrontal cortex (PFC) and hippocampus (Hipp) were assessed. Results CRS procedure induced anxiety‐ and depression‐like behaviors, increased serum cortisol levels, decreased 5‐HT and increased NO levels in the PFC and Hipp areas. NIR TPBM improved behavioral results, decreased serum cortisol levels, increased 5‐HT and decreased NO concentrations in the PFC and Hipp. A dose of 8 J/cm2 of NIR TPBM showed the maximum effects on behavioral and molecular results, while a decline was observed from the optimum effects at both lower (4 J/cm2) and higher (16 J/cm2) doses. Conclusion Our results demonstrated that NIR TPBM had an anti‐anxiety and anti‐depressive effect in CRS mice, which is probably linked to increasing 5‐HT and decreasing NO levels in the PFC and Hipp areas. Also, the maximum anti‐anxiety and anti‐depressive effect was produced at dose of 8 J/cm2. Lasers Surg. Med. © 2019 Wiley Periodicals, Inc.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Transcranial photobiomodulation prevents anxiety and depression via changing serotonin and nitric oxide levels in brain of depression model mice: A study of three different doses of 810 nm laser

et al. 2019

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“…Recently, transcranial NIR PBM therapy has been suggested as a non-invasive neurostimulation modality in the central nervous system and is emerging as a novel promising treatment to defeat depression (Caldieraro et al, 2018; Cassano et al, 2015; Cassano et al, 2016; Salehpour and Rasta, 2017). Previous reports from our laboratory and others have shown that repeated delivery of NIR laser therapy produces an antidepressant-like effect in the FST (Mohammed, 2016; Salehpour et al, 2016; Wu et al, 2012; Xu, et al, 2017) and TST (Xu, et al, 2017). Nevertheless, in the current study, we showed that transcranial NIR PBM therapy for 5 days produced a notable antidepressant-like effect, as indicated by shorter immobility time in the FST and TST.…”

Section: Discussionmentioning

confidence: 74%

Near-infrared photobiomodulation combined with coenzyme Q10 for depression in a mouse model of restraint stress: reduction in oxidative stress, neuroinflammation, and apoptosis

Salehpour

Farajdokht

Cassano

et al. 2019

Brain Research Bulletin

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This study was aimed to evaluate the effects of near-infrared (NIR) photobiomodulation (PBM) combined with coenzyme Q10 (CoQ10) on depressive-like behavior, cerebral oxidative stress, inflammation, and apoptosis markers in mice. To induce a depressive-like model, mice were subjected to sub-chronic restraint stress for 5 consecutive days. NIR PBM (810 nm laser, 33.3 J/cm2) and/or CoQ10 (500 mg/kg/day, gavage) were administered for five days concomitantly with immobilization. Behavior was evaluated by the forced swim test (FST), tail suspension test (TST), and open field test (OFT). Mitochondrial membrane potential as well as oxidative stress, neuroinflammatory, and markers of apoptosis were evaluated in the prefrontal cortex (PFC) and hippocampus (HIP). The serum levels of pro-inflammatory cytokines, cortisol, and corticosterone were also measured. PBM or CoQ10, or the combination, ameliorated depressive-like behaviors induced by restraint stress as indicated by decreased immobility time in both the FST and TST. PBM and/or CoQ10 treatments decreased lipid peroxidation and enhanced total antioxidant capacity (TAC), GSH levels, GPx and SOD activities in both brain areas. The neuroinflammatory response in the HIP and PFC was suppressed, as indicated by decreased NF-kB, p38, and JNK levels in PBM and/or CoQ10 groups. Intrinsic apoptosis biomarkers, BAX, Bcl-2, cytochrome c release, and caspase-3 and −9, were also significantly down-regulated by both treatments. Furthermore, both treatments decreased the elevated serum levels of cortisol, corticosterone, TNF-, and IL-6 induced by restraint stress. Transcranial NIR PBM and CoQ10 therapies may be effective antidepressant strategies for the prevention of psychopathological and behavioral symptoms induced by stress.

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“…The thickness of media tunica was measured using Motic Images version 2.0 and light microscope. The stained sections were anonymously evaluated by a histologist, see also [27].…”

Section: Treatment Processmentioning

confidence: 99%

How do red and infrared low-level lasers affect folliculogenesis cycle in rat’s ovary tissue in comparison with clomiphene under in vivo condition

2017

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Folliculogenesis is a cycle that produces the majority of oocyte. Any disruption to this cycle leads to ovulation diseases, like polycystic ovarian syndrome (PCOS). Treatments include drugs and surgery; lasers have also been used complementarily. Meanwhile, still there is no definite treatment for PCOS. This study investigated the photo-bio stimulation effect of near-infrared and red low-level laser on producing follicles and compared the result with result of using common drug, clomiphene. Therefore, the aim of this study was to propose the use of lasers autonomously treatment. So, there was one question: how do lasers affect folliculogenesis cycle in rat's ovary tissue? In this study, 28 rats were assigned to four groups as follows: control (CT), clomiphene drug (D), red laser (RL), and near-infrared laser (NIRL). Afterwards, 14 rats of RL and NIRL groups received laser on the first 2 days of estrous cycle, each 6 days, for 48 days. During treatment period, each rat received energy density of 5 J/cm 2 . Seven rats in D group received clomiphene. After the experiment, lasers' effects at two wavelengths of 630 and 810 nm groups have been investigated and compared with clomiphene and CT groups. Producing different follicles to complement folliculogenesis cycle increased in NIRL and RL groups, but this increase was significant only in the NIRL group. This indicates that NIRL increases ovarian activity to produce oocyte that certainly can be used in future studies for finding a cure to ovarian negligence to produce more oocyte and treat diseases caused by it like PCOS.

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Therapeutic effects of 10-HzPulsed wave lasers in rat depression model: A comparison between near-infrared and red wavelengths

Cited by 47 publications

References 80 publications

Transcranial photobiomodulation prevents anxiety and depression via changing serotonin and nitric oxide levels in brain of depression model mice: A study of three different doses of 810 nm laser

Transcranial photobiomodulation prevents anxiety and depression via changing serotonin and nitric oxide levels in brain of depression model mice: A study of three different doses of 810 nm laser

Near-infrared photobiomodulation combined with coenzyme Q10 for depression in a mouse model of restraint stress: reduction in oxidative stress, neuroinflammation, and apoptosis

How do red and infrared low-level lasers affect folliculogenesis cycle in rat’s ovary tissue in comparison with clomiphene under in vivo condition

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