Therapeutic Effects of 6‐Gingerol, 8‐Gingerol, and 10‐Gingerol on Dextran Sulfate Sodium‐Induced Acute Ulcerative Colitis in Rats

Abstract

Ulcerative colitis is one of the most common types of inflammatory bowel disease and is multifactorial and relapsing. 6-Gingerol, a component of gingerols extracted from ginger (Zingiber officinale), has been reported to improve ulcerative colitis. The present study aims to investigate the therapeutic efficacy of two analogous forms of 6-gingerol, 8-gingerol, and 10-gingerol, on ulcerative colitis. Colitis was induced in rats through consumption of 5% (w/v) dextran sulfate sodium drinking water for 7 consecutive days. 6-Gingerol, 8-gingerol, and 10-gingerol were then given intraperitoneally at doses of 30 mg kg d for another 7 days, respectively. Body weight change, disease activity index, inflammatory cytokines, and oxidative stress indices were measured, and the colonic tissue injuries were assessed macroscopically and histopathologically. Results showed that all three gingerols attenuated colitic symptoms evoked by dextran sulfate sodium, significantly elevated superoxide dismutase activity, decreased malondialdehyde levels and myeloperoxidase activity in the colon tissue, and markedly reduced the content of tumor necrosis factor alpha and Interleukin 1 beta in the serum. Histological observations showed that all three gingerols obviously accelerated mucosal damage healing. It is concluded that 6-gingerol, 8-gingerol, and 10-gingerol, the three analogues, have a strong and relatively equal efficacy in the treatment of colitis. Copyright © 2017 John Wiley & Sons, Ltd.

Devil's claw (Harpagophytum procumbens) and chronic inflammatory diseases: A concise overview on preclinical and clinical data

“…Inflammatory bowel diseases (IBDs), particularly ulcerative colitis, have been long related to increased burden of oxidative stress (Achitei et al, 2013;Koutroubakis et al, 2004;Rezaie, Parker, & Abdollahi, 2007). To this regard, multiple studies revealed that antioxidant/antiinflammatory herbal extracts could be effective in the management of IBDs symptoms, particularly those related to increased oxidative stress (Chung et al, 2007;Lenoir et al, 2012;Ma et al, 2018;Zhang, Ma, Gao, Sun, & Zhang, 2017). In this context, a preliminary preclinical study was performed in order to evaluate protective effects of devil's claw in IBDs.…”

Pharmacological effects of different ginger juices on the concurrent symptoms in animal models of functional dyspepsia: A comparative study

“…Additionally, 6‐shogaol and 10‐gingerol have effective antioxidant and anti‐inflammatory properties (Dugasani et al, ), which can prevent oxygen free radicals from acting on sulfenyl to degenerate proteins and inactivate enzymes, thus alleviating gastric mucosal damage. Moreover, the aforementioned antioxidant and anti‐inflammatory activities can ameliorate gastrointestinal injury by suppressing the inflammatory cascade reaction (Zhang, Ma, Gao, Sun, & Zhang, ). Currently, there are almost no specific pharmacological researches on 12‐shogaol.…”

Antidiabetic Effects of [10]-Gingerol in Streptozotocin- And High-Fat Diet-Induced Diabetic Rats

“…Ginger, the rhizome of the Zingiber officinale is commonly consumed dietary condiments. Ginger and its constituents show antioxidant activity and prevent the damage of macromolecules, caused by the free radicals/oxidative stress [8]. The compounds derived from natural sources, which are considered to be safe and cost effective, are needed.…”