Therapeutic Effects of Acoustic Cavitation in the Presence of Gold Nanoparticles on a Colon Tumor Model

Abstract

Acoustic cavitation in the presence of gold nanoparticles and intense pulsed light has been introduced as a new way for improving therapeutic effects on tumors by reducing the relative tumor volume and increasing the cumulative survival fraction.

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

“…A recent study [106] on gold NPs, functionalized with PEG and folic acid and activated with ultrasound, showed a promising reduction in cancer cells growth, accompanied by a significant generation of ROS species. Sazgarnia et al [107] also found that the combination of gold NPs, ultrasound and intense pulsed light was a good strategy to further improve the therapeutic effect on tumors. In fact, the combination of these stimuli can cause a rapid heating and a subsequent vaporization of the surrounding medium, contributing to lower the cavitation pressure [108].…”

Gold nanoparticle‐induced sonosensitization enhances the antitumor activity of ultrasound in colon tumor‐bearing mice

“…and Sazgarnia et al. demonstrated an enhanced cavitation activity caused by the presence of AuNPs . The intensive local pressure and temperature upsurges, generation of ROS, shock waves, and jet formation are the clear consequences of collapse cavitation, which ultimately cause considerable damage to the tumor cells.…”

“…The nanoparticles may also act as a nucleation site for cavitation, thus enhancing the ultrasound-induced cavitation. 15,36 The intensive local pressure and temperature upsurges, generation of ROS, shock waves, and jet formation are the clear consequences of collapse cavitation, which ultimately cause considerable damage to the tumor cells. This may be another mechanistic pathway through which AuNPs coupled with ultrasound result in such tumor ablation as observed in the present study.…”

Engineered Porphyrin Loaded Core-Shell Nanoparticles for Selective Sonodynamic Anticancer Treatment

“…In fact, the nanoparticles mediated drug delivery concept is not the only factor that can enhance SDT [20]. Indeed, the existence of appropriate nanoparticles in the milieu might provide nucleation sites decreasing the cavitation threshold that must be reached through ultrasound exposure [36,37]. Moreover, the ease of the manipulation and loading procedure of our PMMANPs, along with their high stability under forced release conditions, make these nanoparticles particularly attractive for theranostic applications.…”