Therapeutic effects of aqueous extract of bioactive active component of Ageratum conyzoides on the ovarian-uterine and hypophysis-gonadal axis in rat with polycystic ovary syndrome: Histomorphometric evaluation and biochemical assessment

Adelakun, Sunday Aderemi; Ukwenya, V.O.; Peter, Akwu Bala; Siyanbade, Adewale Jacob; Akinwumiju, Comfort Oluwakorede

doi:10.1016/j.metop.2022.100201

Cited by 11 publications

(3 citation statements)

References 93 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Focusing on our results, EV-induced PCOS showed an increased number of cystic follicles, absence/or very few corpus luteum along with fewer antral or Gra an follicles [35,36], which is considered as the cessation of folliculogenesis. Chn/Al-AH increased corpus luteum and follicles at different stages of development and decreased cystic follicles, indicating the recovery of the normal histology and nally ovulation in PCOS rats, aligned with the results of previous studies [36 -39].…”

Section: Discussionmentioning

confidence: 60%

Chitosan/Alginate-loaded Astragalus hamosus shows ameliorating effects on lipid profile, inflammatory and hormonal parameters, and reduces miRNA-222 expression in Polycystic Ovary Syndrome Rats

Bostani,

Kohnehshahri,

Tabatabaei

et al. 2024

Preprint

View full text Add to dashboard Cite

Objective This study aimed to investigate the effects of Chitosan/Alginate-loaded Astragalus hamosus extract (AH) on the expression of miRNA-222 and ESR1 genes, pro-inflammatory cytokines, lipid profiles, and sex hormone levels in rats with PCOS-induced by estradiol valerate (EV). Methods 25 female Wistar rats, with an average weight of 180 g, were divided into control and PCOS groups. The PCOS model was induced by a single intramuscular injection of EV (4 mg/kg). After 28 days of PCOS induction, the rats were orally administered Chitosan/Alginate-loaded AH at doses of 5, 10, and 15 mg/kg. Following four weeks of treatment, histological and biochemical parameters, pro-inflammatory cytokines, body weight, and the expression of miRNA-222 and ESR1 genes were evaluated. Results EV-induced PCOS rats exhibited a significant increase in body weight, abnormal lipid profiles, elevated pro-inflammatory cytokine levels, altered sex hormone levels, upregulation of miRNA-222 expression, and downregulation of ESR1 gene expression. The administration of Chitosan/Alginate-loaded AH (Chn/Al-AH) demonstrated ameliorative effects on the PCOS rats, restoring both endocrine and metabolic abnormalities to normal levels and attenuating complications in EV-induced PCOS rats. Notably, it significantly reduced miRNA-222 expression and promoted follicular development at various stages while reducing cystic follicles and increasing corpus luteum formation. Conclusions Chn/Al-AH was found to have beneficial effects in attenuating and improving certain complications in the PCOS rat models.

show abstract

Section: Discussionmentioning

confidence: 60%

Chitosan/Alginate-loaded Astragalus hamosus shows ameliorating effects on lipid profile, inflammatory and hormonal parameters, and reduces miRNA-222 expression in Polycystic Ovary Syndrome Rats

Bostani,

Kohnehshahri,

Tabatabaei

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…The correlation between in silico and classical pharmaceutical investigations implies that the antidiabetic and anticancerous activities of the weed stem mainly from chromenes (precocene I, precocene II, and VMDC) and sterols (betasterol and stigmasterol), respectively [ 45 ]. A. conyzoides has also proven to be a potential adjuvant agent in the treatment of polycystic ovary syndrome [ 54 ]. Extracts of the weed also exhibited antibacterial activity by inhibiting 40.4% of the 464 strains of drug-resistant gram-positive and gram-negative bacteria [ 55 ].…”

Section: Biological Activitymentioning

confidence: 99%

“…A. conyzoides has also proven to be a potential adjuvant agent in the treatment of polycystic ovary syndrome [54]. Extracts of the weed also exhibited antibacterial activity by inhibiting 40.4% of the 464 strains of drug-resistant gram-positive and gram-negative bacteria [55].…”

Section: Pharmacological Propertiesmentioning

confidence: 99%

Ecology, Biology, Environmental Impacts, and Management of an Agro-Environmental Weed Ageratum conyzoides

Kaur

Singh

et al. 2023

Plants

View full text Add to dashboard Cite

Ageratum conyzoides L. (Billy goat weed; Asteraceae) is an annual herbaceous plant of American origin with a pantropical distribution. The plant has unique biological attributes and a raft of miscellaneous chemical compounds that render it a pharmacologically important herb. Despite its high medicinal value, the constant spread of the weed is noticeable and alarming. In many countries, the weed has severely invaded the natural, urban, and agroecosystems, thus presenting management challenges to natural resource professionals and farmers. Its interference with agricultural crops, grassland forbs, forest ground flora, and its ability to replace native plant species are of serious concern. Therefore, it is pertinent to monitor its continuous spread, its entry into new geographic regions, the extent of its impact, and the associated evolutionary changes. While management strategies should be improvised to control its spread and reduce its adverse impacts, the possible utilization of this noxious weed for pharmacological and agronomic purposes should also be explored. The objective of this review is to provide a detailed account of the global distribution, biological activities, ecological and environmental impacts, and strategies for the management of the agro-environmental weed A. conyzoides.

show abstract

Ethnopharmacological survey of aromatic medicinal plants used in the treatment of the most recurrent diseases in the locality of Oyem, Gabon

Obiang

Misso

Mba

et al. 2023

ADV TRADIT MED (ADTM)

View full text Add to dashboard Cite

Therapeutic effects of aqueous extract of bioactive active component of Ageratum conyzoides on the ovarian-uterine and hypophysis-gonadal axis in rat with polycystic ovary syndrome: Histomorphometric evaluation and biochemical assessment

Cited by 11 publications

References 93 publications

Chitosan/Alginate-loaded Astragalus hamosus shows ameliorating effects on lipid profile, inflammatory and hormonal parameters, and reduces miRNA-222 expression in Polycystic Ovary Syndrome Rats

Chitosan/Alginate-loaded Astragalus hamosus shows ameliorating effects on lipid profile, inflammatory and hormonal parameters, and reduces miRNA-222 expression in Polycystic Ovary Syndrome Rats

Ecology, Biology, Environmental Impacts, and Management of an Agro-Environmental Weed Ageratum conyzoides

Ethnopharmacological survey of aromatic medicinal plants used in the treatment of the most recurrent diseases in the locality of Oyem, Gabon

Contact Info

Product

Resources

About