Therapeutic effects of curcumin and ursodexycholic acid on non-alcoholic fatty liver disease

Gheibi, Shahsanam; Ghaleh, Hadi Esmaeili Gouvarchin; Motlagh, Bahman Mansori; Azarbayjani, Anahita Fathi; Zarei, Leila

doi:10.1016/j.biopha.2019.108938

Cited by 30 publications

(23 citation statements)

References 37 publications

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“…Oxidative Medicine and Cellular Longevity therapeutic attempts have been made in the recent past without obtaining significant results, sometimes even controversial. This is the case, for example, of long-term treatment with insulin-sensitizers, vitamin E, pioglitazone, or their association [38][39][40][41]. Several studies reported the role of the intestinal microbiota as a very important factor involved in the genesis of the inflammatory cascades correlated with the NAFLD and the MS, but there are not yet sufficient scientific evidences to support the transferability of the results highlighted by some studies on this topic in daily clinical practice [42].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Effect Derived from Silybin with Vitamin D and Vitamin E Administration on Clinical, Metabolic, Endothelial Dysfunction, Oxidative Stress Parameters, and Serological Worsening Markers in Nonalcoholic Fatty Liver Disease Patients

Federico

Dallio

Masarone

et al. 2019

Oxidative Medicine and Cellular Longevity

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Nowadays, the nonalcoholic fatty liver disease represents the main chronic liver disease in the Western countries, and the correct medical therapy remains a big question for the scientific community. The aim of our study was to evaluate the effect derived from the administration for six months of silybin with vitamin D and vitamin E (RealSIL 100D®) on metabolic markers, oxidative stress, endothelial dysfunction, and worsening of disease markers in nonalcoholic fatty liver disease patients. We enrolled 90 consecutive patients with histological diagnosis of nonalcoholic fatty liver disease and 60 patients with diagnosis of reflux disease (not in therapy) as healthy controls. The nonalcoholic fatty liver disease patients were randomized into two groups: treated (60 patients) and not treated (30 patients). We performed a nutritional assessment and evaluated clinical parameters, routine home tests, the homeostatic model assessment of insulin resistance, NAFLD fibrosis score and fibrosis-4, transient elastography and controlled attenuation parameter, thiobarbituric acid reactive substances, tumor necrosis factor α, transforming growth factor β, interleukin-18 and interleukin-22, matrix metalloproteinase 2, epidermal growth factor receptor, insulin growth factor-II, cluster of differentiation-44, high mobility group box-1, and Endocan. Compared to the healthy controls, the nonalcoholic fatty liver disease patients had statistically significant differences for almost all parameters evaluated at baseline (p<0.05). Six months after the baseline, the proportion of nonalcoholic fatty liver disease patients treated that underwent a statistically significant improvement in metabolic markers, oxidative stress, endothelial dysfunction, and worsening of disease was greater than not treated nonalcoholic fatty liver disease patients (p<0.05). Even more relevant results were obtained for the same parameters by analyzing patients with a concomitant diagnosis of metabolic syndrome (p<0.001). The benefit that derives from the use of RealSIL 100D could derive from the action on more systems able to advance the pathology above all in that subset of patients suffering from concomitant metabolic syndrome.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the Effect Derived from Silybin with Vitamin D and Vitamin E Administration on Clinical, Metabolic, Endothelial Dysfunction, Oxidative Stress Parameters, and Serological Worsening Markers in Nonalcoholic Fatty Liver Disease Patients

Federico

Dallio

Masarone

et al. 2019

Oxidative Medicine and Cellular Longevity

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“…Another study from Iran, conducted in rats, showed a synergistic effect of curcumin and UDCA in the treatment of NAFLD [76]. This paper focused more on the inflammation and necrosis/apoptosis axis.…”

Section: Pharmacotherapiesmentioning

confidence: 99%

Why Bile Acids Are So Important in Non-Alcoholic Fatty Liver Disease (NAFLD) Progression

Gottlieb

Canbay

2019

Cells

113

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Non-alcoholic fatty liver disease (NAFLD) is a complex disease, affecting not just the liver, but also all other organs in the body. Despite an increasing amount of people worldwide developing NAFLD and having it progress to non-alcoholic steatohepatitis (NASH) and potentially cirrhosis, there is still no approved therapy. Therefore, huge efforts are being made to find and develop a successful treatment. One of the special interests is understanding the liver–gut axis and especially the role of bile acids in the progression of NAFLD. Farnesoid X receptor (FXR)-agonists have been approved und used in other liver diseases, such as primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC), and have shown signs of being able to decrease inflammation and potentially steatosis. This review will mainly focus on targets/ligands that play an important role in bile acid metabolism and give an overview of ongoing clinical as well as pre-clinical trials. With the complexity of the issue, we did not aim at giving a complete review, rather highlighting important targets and potential treatments that could be approved for NAFLD/NASH treatment within the next few years.

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“…Several pieces of research showed that anti-hyperglycaemic agents, such as GLP-1 receptor agonist, DPP-4 inhibitors, and thiazolidinendiones, exert anti-psoriasis effects independent of weight loss and glycemic control by targeting keratinocyte proliferation and skin inflammation [165]. Moreover, some reports suggest that treatment with pioglitazone and ursodeoxycholic acid may improve both psoriatic skin lesions and NAFLD liver injury, but further studies are needed to clarify the usefulness of such treatments [166,167,168].…”

Section: Resultsmentioning

confidence: 99%

NAFLD and Extra-Hepatic Comorbidities: Current Evidence on a Multi-Organ Metabolic Syndrome

Rosato

Masarone

Dallio

et al. 2019

IJERPH

104

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Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide and its incidence is definitely increasing. NAFLD is a metabolic disease with extensive multi-organ involvement, whose extra-hepatic manifestations include type 2 diabetes mellitus, cardiovascular disease, obstructive sleep apnea, chronic kidney disease, osteoporosis, and polycystic ovarian syndrome. Recently, further evidence has given attention to pathological correlations not strictly related to metabolic disease, also incorporating in this broad spectrum of systemic involvement hypothyroidism, psoriasis, male sexual dysfunction, periodontitis, and urolithiasis. The most common cause of mortality in NAFLD is represented by cardiovascular disease, followed by liver-related complications. Therefore, clinicians should learn to screen and initiate treatment for these extra-hepatic manifestations, in order to provide appropriate multidisciplinary assessments and rigorous surveillance. This review evaluates the current evidence regarding extra-hepatic associations of NAFLD, focusing on the pathogenic hypothesis and the clinical implications.

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Therapeutic effects of curcumin and ursodexycholic acid on non-alcoholic fatty liver disease

Cited by 30 publications

References 37 publications

Evaluation of the Effect Derived from Silybin with Vitamin D and Vitamin E Administration on Clinical, Metabolic, Endothelial Dysfunction, Oxidative Stress Parameters, and Serological Worsening Markers in Nonalcoholic Fatty Liver Disease Patients

Evaluation of the Effect Derived from Silybin with Vitamin D and Vitamin E Administration on Clinical, Metabolic, Endothelial Dysfunction, Oxidative Stress Parameters, and Serological Worsening Markers in Nonalcoholic Fatty Liver Disease Patients

Why Bile Acids Are So Important in Non-Alcoholic Fatty Liver Disease (NAFLD) Progression

NAFLD and Extra-Hepatic Comorbidities: Current Evidence on a Multi-Organ Metabolic Syndrome

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