Therapeutic effects of curcumin on age-induced alterations in daily rhythms of clock genes and Sirt1 expression in the SCN of male Wistar rats

Kukkemane, Kowshik; Jagota, Anita

doi:10.1007/s10522-018-09794-y

Cited by 16 publications

(5 citation statements)

References 64 publications

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“…Even more recently, it has been hypothesized that the antiaging effect of CUR may rely on the control of core clock genes on which Sirt1 belongs alongside rBmal1, rCry1, rCry2, rPer1, rPer2, and rRev-erba. CUR treatment in middle aged male Wistar rats restored the phase and daily pulse of rCry1, rCry2, rPer1, and rPer2 as in the young, whereas only rPer1 and partly rBmal1, rCry1, and rCry2 were restored in the old ones [164]. Moreover, it has been shown that CUR mitigated mouse ovarian aging, upgraded embryonic development, promoted oocyte maturation and fertilization via improvement of ovarian hormones, BioMed Research International and elevated the amounts of SIRT1 and 3 genes as well as attenuation of aging-associated oxidative stress and cell death [165].…”

Section: Studies Of Cell Senescence: Evidence From Mice Andmentioning

confidence: 86%

Effects of Curcumin on Aging: Molecular Mechanisms and Experimental Evidence

Bahrami

Montecucco

Carbone

et al. 2021

BioMed Research International

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Aging is characterized by a progressive inability to maintain homeostasis, self-repair, renewal, performance, and fitness of different tissues throughout the lifespan. Senescence is occurring following enormous intracellular or extracellular stress stimuli. Cellular senescence serves as an antiproliferative process that causes permanent cell cycle arrest and restricts the lifespan. Senescent cells are characterized by terminal cell cycle arrest, enlarged lysosome, and DNA double-strand breaks as well as lipofuscin granularity, senescence-associated heterochromatin foci, and activation of DNA damage response. Curcumin, a hydrophobic polyphenol, is a bioactive chemical constituent of the rhizomes of Curcuma longa Linn (turmeric), which has been extensively used for the alleviation of various human disorders. In addition to its pleiotropic effects, curcumin has been suggested to have antiaging features. In this review, we summarized the therapeutic potential of curcumin in the prevention and delaying of the aging process.

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Section: Studies Of Cell Senescence: Evidence From Mice Andmentioning

confidence: 86%

Effects of Curcumin on Aging: Molecular Mechanisms and Experimental Evidence

Bahrami

Montecucco

Carbone

et al. 2021

BioMed Research International

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“…Thus, the development of the metabolic syndrome may be significantly influenced by hypothalamic inflammation. It is worth mentioning that the interaction between SIRT1 and the hypothalamic clock genes (i.e., rBmal1, rPer1, rPer2, rCry1, rCry2 , and rRev-erbα ) decreases with age, which would lead to reduced dorsal medial hypothalamic (DMH) and lateral hypothalamic (LH) activity [ 27 , 28 ].…”

Section: Changes In Structure and Function In Endocrine Glands During...mentioning

confidence: 99%

“…With aging, the hypothalamus undergoes the following changes in aging: a significant reduction in blood supply [ 16 ]; the proliferation of connective tissue [ 17 ]; a change in cell morphology [ 18 ]; a reduction in the gonadotropin-releasing hormone (GnRH) [ 20 ], the growth hormone releasing hormone (GHRH) [ 20 ], the thyrotropin-releasing hormone (TRH) [ 20 ], and in the monoamine neurotransmitter levels [ 23 ]. Molecular mechanisms of aging include the following: a blocked TNF-α and IL-1β signaling; the loss of neural stem cells [ 24 ]; reduced autophagy [ 25 ]; enhanced mTOR activity [ 26 ]; and reduced SIRT1 expression in SCN, thereby resulting in reduced dorsal medial hypothalamic (DMH) and lateral hypothalamic (LH) activity [ 27 , 28 ].…”

Section: Figurementioning

confidence: 99%

“… The changes and molecular mechanisms of the pituitary aging hormone. Proliferation of the pituitary stem cells can be enhanced by IL-6 supplementation, and they can also achieve anti-aging purposes [ 28 ]. When the levels of the pituitary aging hormones changed, the levels of prolactin (PRL) and the follicle-stimulating hormone (FSH) increased [ 32 ], whereas the adrenocorticotropic hormone (ACTH) and the thyroid-stimulating hormone (TSH) did not change significantly [ 34 ].…”

Section: Figurementioning

confidence: 99%

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The Timing Sequence and Mechanism of Aging in Endocrine Organs

Fang

Wang

et al. 2023

Cells

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The world is increasingly aging, and there is an urgent need to find a safe and effective way to delay the aging of the body. It is well known that the endocrine glands are one of the most important organs in the context of aging. Failure of the endocrine glands lead to an abnormal hormonal environment, which in turn leads to many age-related diseases. The aging of endocrine glands is closely linked to oxidative stress, cellular autophagy, genetic damage, and hormone secretion. The first endocrine organ to undergo aging is the pineal gland, at around 6 years old. This is followed in order by the hypothalamus, pituitary gland, adrenal glands, gonads, pancreatic islets, and thyroid gland. This paper summarises the endocrine gland aging-related genes and pathways by bioinformatics analysis. In addition, it systematically summarises the changes in the structure and function of aging endocrine glands as well as the mechanisms of aging. This study will advance research in the field of aging and help in the intervention of age-related diseases.

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“…However, the concurrent administration of curcumin ameliorated these behavioural changes and modulated the expression of the Period Circadian Regulator 1 (PER1) gene [189]. In other animal studies, age-induced alterations in the daily rhythms of clock genes were restored by curcumin administration [190,191]. The PER1 gene and other clock genes are involved in biological processes such as feeding behaviour, sleep deprivation and vulnerability to depression [192][193][194][195].…”

Section: Clock Gene Expressionmentioning

confidence: 99%

Potential Role of Curcumin for the Treatment of Major Depressive Disorder

Lopresti

2022

CNS Drugs

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Curcumin is the major biologically active polyphenolic constituent in the turmeric plant (Curcuma longa) that has been shown to have antioxidant, anti-inflammatory, neuroprotective, anticancer, antimicrobial, and cardioprotective effects. Interest in curcumin as a treatment for mental health conditions has increased and there is an expanding body of preclinical and clinical research examining its antidepressant and anxiolytic effects. In this narrative review, human trials investigating the effects of curcumin for the treatment of depression or depressive symptoms are summarised. Using findings from in vitro, animal, and human trials, possible biological mechanisms associated with the antidepressant effects of curcumin are also explored. To increase the understanding of curcumin for the treatment of depression, directions for future research are proposed. Key PointsEvidence from animal and human trials confirms curcumin is a promising treatment for depression.Curcumin has multiple biological actions that may account for its antidepressant effects.More research is required to increase the understanding of the antidepressant effects of curcumin.

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Therapeutic effects of curcumin on age-induced alterations in daily rhythms of clock genes and Sirt1 expression in the SCN of male Wistar rats

Cited by 16 publications

References 64 publications

Effects of Curcumin on Aging: Molecular Mechanisms and Experimental Evidence

Effects of Curcumin on Aging: Molecular Mechanisms and Experimental Evidence

The Timing Sequence and Mechanism of Aging in Endocrine Organs

Potential Role of Curcumin for the Treatment of Major Depressive Disorder

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