Therapeutic Effects of Curcumol in Several Diseases; An Overview

Hashem, Sheema; Nisar, Sabah; Sageena, Geetanjali; Macha, Muzafar A.; Yadav, Santosh K.; Krishnankutty, Roopesh; Uddin, Shahab; Haris, Mohammad; Bhat, Ajaz A.

doi:10.1080/01635581.2020.1749676

Cited by 55 publications

(29 citation statements)

References 114 publications

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“…Mounting studies have shown that, the Rhizoma Curcumae extracts, which have broad-spectrum antitumor effects, play an important role in the effect of herb medicine. Curcumin, which comes from the same family and genus with curdione, has the anti-proliferation effect on uterine sarcoma [36,40]. As one of the extracts of Rhizoma Curcumae, curdione have the same chemical structure with curcumin, so we speculate that curdione has similar anti-tumor effect on uLMS.…”

Section: Discussionmentioning

confidence: 79%

“…Rhizoma Curcuma has been reported with antitumor effect [26], which mainly dependent on its essential oils. The effective bioactive compounds of the essential oils including: β-elemene, curcumol, curcumin, curdione, furanodiene, furanodienone, and germacrone have been reported with anti-platelet aggregation [27,28], anti-in ammatory [29], antibacterial [30], neuroprotective properties [31], prevent cardiotoxicity [32], and anti-tumor effect [26,30,[33][34][35][36]. Bene cial therapeutic effect of curdione has been reported in breast cancers [34], but the potential anti-cancer effect in uLMS and the underlying mechanism is still unclear.…”

Section: Introductionmentioning

confidence: 99%

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Curdione induces G2/M phage arrest, apoptosis and autophagy via COX2 mediate IDO1 expression through PKCδ/ GSK3β/β-catenin pathway in human uterine leiomyosarcoma

Wei

Wang

et al. 2020

Preprint

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Background Curdione, one of active ingredients of a traditional Chinese herb medicine-Curcuma zedoary, has been reported with beneficial therapeutic effects in lots of cancer types. However, the potential anti-cancer effect in uterine leiomyosarcoma (uLMS) and the underlying mechanisms are still unclear.Methods The aim of this study was to explore the potential effect and mechanisms of curdione on uLMS in vitro and vivo with uLMS cell lines and mouse xenograft tumor model respectively.Results Curdione triggered anti-proliferation effect in uLMS cell lines by inducing cell cycle arrest at G2/M phase, caspase-mediated cell apoptosis, and pro-death cell autophagy. Indoleamine-2,3-dioxygenase-1 (IDO1), which was dependent on cyclooxygenase-2 (COX2), mediated the anti-proliferation effect of curdione. Curdione down-regulated IDO1 expression and promoted the dephosphorylation of protein kinase c (PKC), glycogen synthase kinase-3 beta (GSK3β) and β-catenin in cell lines. PKC/GSK3β/β-catenin pathway responsible for constitutive IDO1 expression in uLMS. COX2 mediate the promotion effect of curdione on the PKC/GSK3β/β catenin pathway activity, which was detected by COX2 inhibitor, and further confirmed by COX2 siRNA and COX2 overexpression. The pathway activity was inhibited by COX2-siRNA and enhanced by COX2 overexpression. In turn, the pathway inhibitor suppressed IDO1 expression. The anti-proliferation effect of curdione on uterine leiomyosarcoma were further confirmed in vivo. Echoing to the results in vitro, the underline mechanism involved in COX2-mediated IDO1 down-regulation via PKCδ/GSK3β/β-catenin pathway.Conclusion COX2-mediated IDO1 down-regulation via PKCδ/GSK3β/β-catenin pathway involved in the anti-proliferation effect of curdione on uterine leiomyosarcoma in vitro and vivo.

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Section: Discussionmentioning

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Curdione induces G2/M phage arrest, apoptosis and autophagy via COX2 mediate IDO1 expression through PKCδ/ GSK3β/β-catenin pathway in human uterine leiomyosarcoma

Wei

Wang

et al. 2020

Preprint

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“…Curcuma zedoary, a traditional Chinese medicine formulation that promotes blood circulation, removes blood stasis, and alleviates pain, has been widely used for treating gynecological diseases. Curcumin is one of the bioactive compounds of Rhizoma Curcumae with antiproliferation effects on uterine sarcoma (18,31), and uterine leiomyosarcoma (32,33). Curdione is an active component of Rhizoma Curcuma; it has the same family and genus source with curcumin and structurally similar to curcumin, which leads us to hypothesize that it might have an analogous effect on uLMS.…”

Section: Discussionmentioning

confidence: 99%

“…Currently, chemotherapy is one of the main strategies against cancer; herbal medicine gained considerable interest in recent years as an alternative to chemotherapy drugs. For instance, Curcuma zedoary has been reported with an anti-tumor effect (8)(9)(10)(11), and its bioactive compounds of the essential oils including b-elemene, curcumol, curcumin, curdione, furanodiene, furanodienone, and germacrone exhibit antithromboric (12,13), anti-inflammatory, (14) antibacterial (15), neuroprotective properties (16), cardio-protective (17), and anti-tumor effects (18). The therapeutic effects of curdione have been reported in breast cancer (19), while the potential anti-tumor effect in uLMS is still unclear.…”

Section: Introductionmentioning

confidence: 99%

Curdione Induces Antiproliferation Effect on Human Uterine Leiomyosarcoma via Targeting IDO1

Wei

et al. 2021

Front. Oncol.

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ObjectivesCurdione is one of the active ingredients of a traditional Chinese herbal medicine-Curcuma zedoary and established anti-tumor effects. Uterine leiomyosarcoma (uLMS) is a rare gynecological malignancy, with no standard therapeutic regimen at present. The aim of this study was to explore the potential anti-tumor impact of curdione in uLMS and elucidate the underlying mechanisms.MethodsIn vitro functional assays were performed in the SK-UT-1 and SK-LMS-1 cell lines. The in vivo model of uLMS was established by subcutaneously injecting SK-UT-1 cells, and the tumor-bearing mice were intraperitoneally injected with curdione. Tumor weight and volume were measured at specific time points. The biosafety was evaluated by monitoring changes of body weight and the histopathology in the liver and kidney. The expression levels of relevant proteins were analyzed by western blotting and immunohistochemistry.ResultsCurdione decreased the viability and proliferation of uLMS cells in a concentration and time-dependent manner. In addition, the curdione-treated cells exhibited significantly higher rates of apoptosis and autophagic death. Curdione also decreased the tumor weight and volume in the SK-UT-1 xenograft model compared to the untreated control without affecting the body bodyweight or pathological injury of liver and kidney tissues. At the molecular level, the anti-tumor effects of curdione were mediated by indoleamine-2, 3-dioxygenase-1 (IDO1).ConclusionCurdione exhibited an anti-uLMS effect in vitro and in vivo; the underlying mechanism involved in IDO1 mediate apoptosis, autophagy, and G2/M phase arrest.

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“…Curcumol is extracted from the traditional Chinese medicine Rhizoma curcumae , which has been reported to possess multiple pharmacological bioactivities, including antioxidant, anti-inflammatory, antifibrosis, antimicrobial and antitumor activities ( 14 – 16 ). It has been demonstrated that curcumol exerts antitumor effects against multiple types of cancer, including gastric cancer ( 17 ), cholangiocarcinoma ( 18 ), nasopharyngeal carcinoma ( 19 ) and colorectal carcinoma ( 20 ).…”

Section: Introductionmentioning

confidence: 99%

Curcumol inhibits the viability and invasion of colorectal cancer cells via miR‑30a‑5p and Hippo signaling pathway

Qin

et al. 2021

Oncol Lett

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MicroRNA-30a-5p (miR-30a-5p), which functions as a tumor suppressor, has been reported to be downregulated in colorectal cancer (CRC) tissues and to be associated with cancer invasion. However, the detailed regulatory mechanism of curcumol in the malignant progression of CRC remains unknown. MTT, Transwell, scratch, western blotting and reverse transcription-quantitative PCR assays were performed to examine how curcumol inhibited CRC cell viability, invasion and migration, and to detect the role of miR-30a-5p and curcumol in the invasion and Hippo signaling pathways of CRC cells. The present study revealed that miR-30a-5p expression was downregulated in human CRC tissues and cells. The results demonstrated that miR-30a-5p downregulation was accompanied by the inactivation of the Hippo signaling pathway, which was demonstrated to promote CRC cell viability, invasion and migration. Curcumol treatment was identified to increase miR-30a-5p expression and to activate the Hippo signaling pathway, which in turn inhibited the invasion and migration of CRC cells. Overexpression of miR-30a-5p enhanced the effects of curcumol on cell invasion and migration, and the Hippo signaling pathway in CRC cells. Furthermore, downregulation of miR-30a-5p reversed the effects of curcumol on cell invasion and migration, and the Hippo signaling pathway in CRC cells. These findings identified novel signaling pathways associated with miR-30a-5p and revealed the effects of curcumol on miR-30a-5p expression. Therefore, curcumol may serve as a potential therapeutic strategy to delay CRC progression.

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Therapeutic Effects of Curcumol in Several Diseases; An Overview

Cited by 55 publications

References 114 publications

Curdione induces G2/M phage arrest, apoptosis and autophagy via COX2 mediate IDO1 expression through PKCδ/ GSK3β/β-catenin pathway in human uterine leiomyosarcoma

Curdione induces G2/M phage arrest, apoptosis and autophagy via COX2 mediate IDO1 expression through PKCδ/ GSK3β/β-catenin pathway in human uterine leiomyosarcoma

Curdione Induces Antiproliferation Effect on Human Uterine Leiomyosarcoma via Targeting IDO1

Curcumol inhibits the viability and invasion of colorectal cancer cells via miR‑30a‑5p and Hippo signaling pathway

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