Therapeutic effects of ginseng and ginsenosides on colorectal cancer

Zhao, Linxian; Zhang, Yueming; Li, Yajuan; Li, Chen; Shi, Kai; Zhang, Kai; Liu, Ning

doi:10.1039/d2fo00899h

Cited by 21 publications

(7 citation statements)

References 129 publications

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“…On the basis of their chemical structures, ginsenosides can be classed into three types: dammarane, oleanane, and oleanolic acid types. Among them, dammarane can be further divided into protopanaxadiol (PPD), protopanaxatriol (PPT), and ocotillol (OCT) types ( 42 ). PPD-type ginsenosides mainly include Rb1, Rb2, Rb3, Rc, Rd, Rg3, and Rh2.…”

Section: Ginseng and Ginsenosidesmentioning

confidence: 99%

Pharmacological effects of ginseng and ginsenosides on intestinal inflammation and the immune system

Zhao,

Zhang,

Zhang

2024

Front. Immunol.

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Intestinal inflammatory imbalance and immune dysfunction may lead to a spectrum of intestinal diseases, such as inflammatory bowel disease (IBD) and gastrointestinal tumors. As the king of herbs, ginseng has exerted a wide range of pharmacological effects in various diseases. Especially, it has been shown that ginseng and ginsenosides have strong immunomodulatory and anti-inflammatory abilities in intestinal system. In this review, we summarized how ginseng and various extracts influence intestinal inflammation and immune function, including regulating the immune balance, modulating the expression of inflammatory mediators and cytokines, promoting intestinal mucosal wound healing, preventing colitis-associated colorectal cancer, recovering gut microbiota and metabolism imbalance, alleviating antibiotic-induced diarrhea, and relieving the symptoms of irritable bowel syndrome. In addition, the specific experimental methods and key control mechanisms are also briefly described.

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Section: Ginseng and Ginsenosidesmentioning

confidence: 99%

Pharmacological effects of ginseng and ginsenosides on intestinal inflammation and the immune system

Zhao,

Zhang,

Zhang

2024

Front. Immunol.

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“…Frontiers in Pharmacology frontiersin.org capacity to regulate tumor-associated immune responses (Wang et al, 2020;Zhao et al, 2022) and has also been proved to mitigate the symptoms of cancer cachexia by reducing the levels of proinflammatory cytokines TNF-α and IL-6 (Lu et al, 2020). Furthermore, cancer cachexia is intricately linked to digestive and metabolic dysregulation, characterized by diminished food intake and metabolic changes (Baracos et al, 2018).…”

Section: Different Populationsmentioning

confidence: 99%

Can Chinese herbal medicine offer feasible solutions for newly diagnosed esophageal cancer patients with malnutrition? a multi-institutional real-world study

Lu,

Tseng,

et al. 2024

Front. Pharmacol.

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BackgroundEsophageal cancer (EC) is a major cause of cancer-related mortality in Taiwan and globally. Patients with EC are highly prone to malnutrition, which adversely affects their prognosis. While Chinese herbal medicine (CHM) is commonly used alongside conventional anti-cancer treatments, its long-term impact on EC patients with malnutrition remains unclear.MethodsThis study utilized a multi-center cohort from the Chang Gung Research Database, focusing on the long-term outcomes of CHM in EC patients with malnutrition between 1 January 2001, and 31 December 2018. Patients were monitored for up to 5 years or until death. Overall survival (OS) rates were calculated using the Kaplan-Meier method. Overlap weighting and landmark analysis were employed to address confounding and immortal time biases. Additionally, the study analyzed prescription data using a CHM network to identify key CHMs for EC with malnutrition, and potential molecular pathways were investigated using the Reactome database.ResultsEC patients with malnutrition who used CHM had a higher 5-year OS compared with nonusers (22.5% vs. 9% without overlap weighting; 24.3% vs. 13.3% with overlap weighting; log-rank test: p = 0.006 and 0.016, respectively). The median OS of CHM users was significantly longer than that of nonusers (19.8 vs. 12.9 months, respectively). Hazard ratio (HR) analysis showed a 31% reduction in all-cause mortality risk for CHM users compared with nonusers (HR: 0.69, 95% confidence interval: 0.50–0.94, p = 0.019). We also examined 665 prescriptions involving 306 CHM, with Hedyotis diffusa Willd. exhibiting the highest frequency of use. A CHM network was created to determine the primary CHMs and their combinations. The identified CHMs were associated with the regulation of immune and metabolic pathways, particularly in areas related to immune modulation, anti-cancer cachexia, promotion of digestion, and anti-tumor activity.ConclusionThe results of this study suggest a correlation between CHM use and improved clinical outcomes in EC patients with malnutrition. The analysis identified core CHMs and combinations of formulations that play a crucial role in immunomodulation and metabolic regulation. These findings lay the groundwork for more extensive research on the use of CHM for the management of malnutrition in patients with EC.

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“…Ginsenosides have shown significant anti-cancer potential in breast, gastrointestinal, colorectal and other cancers. 38–40 An overview of the progress in research on ginsenosides in lung cancer over the last ten years is reviewed. Among them, Rg3 and Rh2, which are the most studied ginsenoside monomers, have shown great potential in the treatment of lung cancer.…”

Section: Anti-tumour Effects Of Ginsenosides In Lung Cancermentioning

confidence: 99%

Ginsenosides: a potential natural medicine to protect the lungs from lung cancer and inflammatory lung disease

Wang,

Zhang,

Song

et al. 2023

Food Funct.

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Therapeutic effects of ginseng and ginsenosides on colorectal cancer

Abstract: Colorectal cancer (CRC) is among the most common malignant diseases with high morbidity and mortality rates. Ginseng and its major extracts, ginsenosides, have been used in medical fields for thousands...

Cited by 21 publications

References 129 publications

Pharmacological effects of ginseng and ginsenosides on intestinal inflammation and the immune system

Pharmacological effects of ginseng and ginsenosides on intestinal inflammation and the immune system

Can Chinese herbal medicine offer feasible solutions for newly diagnosed esophageal cancer patients with malnutrition? a multi-institutional real-world study

Ginsenosides: a potential natural medicine to protect the lungs from lung cancer and inflammatory lung disease

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