Therapeutic Effects of Green Tea on Nonalcoholic Fatty Liver Disease in 10-16-Year-Old Children

Rostampour, Noushin; Kasiri, K A; Hashemi-Dehkordi, Elham; Taheri, Abdol Majid; Broujeni, Anahita Farahzad; Rafieian-Kopaei, Mahmoud

doi:10.7860/jcdr/2019/35236.12986

Cited by 4 publications

(2 citation statements)

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“…Clinical trials also indicate that oral intake of green tea shows protective effects against FLD. Oral intake of 500 mg green tea tablet containing 50 mg of standardized total polyphenols 3 times per day for 3 months effectively decreased hepatic fat accumulation, alleviated fatty liver grade, and improved liver function in 52 NAFLD patients aged 10 to 16 years [ 163 ]. Additionally, the intake of 500 mg of the green tea extract for 3 months could improve the serum levels of ALT, AST, lipid profiles, and inflammatory markers in NAFLD patients [ 164 ].…”

Section: Clinical Trials Of Plant-based Foods and Their Bioactive mentioning

confidence: 99%

Plant‐Based Foods and Their Bioactive Compounds on Fatty Liver Disease: Effects, Mechanisms, and Clinical Application

Gan

Shang

et al. 2021

Oxidative Medicine and Cellular Longevity

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Fatty liver disease (FLD), including nonalcoholic fatty liver disease (NAFLD) and alcoholic fatty liver disease (AFLD), is a serious chronic metabolic disease that affects a wide range of people. Lipid accumulation accompanied by oxidative stress and inflammation in the liver is the most important pathogenesis of FLD. The plant-based, high-fiber, and low-fat diet has been recommended to manage FLD for a long time. This review discusses the current state of the art into the effects, mechanisms, and clinical application of plant-based foods in NAFLD and AFLD, with highlighting related molecular mechanisms. Epidemiological evidence revealed that the consumption of several plant-based foods was beneficial to alleviating FLD. Further experimental studies found out that fruits, spices, teas, coffee, and other plants, as well as their bioactive compounds, such as resveratrol, anthocyanin, curcumin, and tea polyphenols, could alleviate FLD by ameliorating hepatic steatosis, oxidative stress, inflammation, gut dysbiosis, and apoptosis, as well as regulating autophagy and ethanol metabolism. More importantly, clinical trials confirmed the beneficial effects of plant-based foods on patients with fatty liver. However, several issues need to be further studied especially the safety and effective doses of plant-based foods and their bioactive compounds. Overall, certain plant-based foods are promising natural sources of bioactive compounds to prevent and alleviate fatty liver disease.

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Section: Clinical Trials Of Plant-based Foods and Their Bioactive mentioning

confidence: 99%

Plant‐Based Foods and Their Bioactive Compounds on Fatty Liver Disease: Effects, Mechanisms, and Clinical Application

Gan

Shang

et al. 2021

Oxidative Medicine and Cellular Longevity

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“…Reduced high-sensitivity c-reactive protein (hs-CRP) levels and improved visceral fat/subcutaneous fat (V/S) area ratio and liver-spleen (L/S) ratio suggested that catechins combined with diet and exercise therapy could reduce the oxidative stress in NASH patients to prevent NASH progression. In children with NAFLD aged 10–16 years, catechins have shown significant antioxidant and hypolipidemic effects, and can effectively reduce BMI and liver fat accumulation as well as improve liver function, lower ALT and AST, and improve dyslipidemia …”

Section: Structure Metabolism and Effects Of Tea Active Compounds On ...mentioning

confidence: 99%

Regulatory Effects and Molecular Mechanisms of Tea and Its Active Compounds on Nonalcoholic Fatty Liver Disease

Yang

Huang

et al. 2023

J. Agric. Food Chem.

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Nonalcoholic fatty liver disease (NAFLD), the most common chronic liver disease, is a multifactorial disease resulting from the interaction between environment, genetic background, and metabolic stress. Most treatments for NAFLD include dietary intervention and exercise show limited efficacy due to the complex mechanisms involved in NAFLD. Meanwhile, drug therapy is accompanied by serious side effects. The development of high-efficiency natural supplements is a sustainable strategy for the prevention and treatment of NAFLD. As the second most consumed beverage, tea has health benefits that have been widely recognized. Nevertheless, the intervention of tea active compounds in NAFLD has received limited attention. Tea contains abundant bioactive compounds with potential effects on NAFLD, such as catechins, flavonoids, theanine, tea pigments, and tea polysaccharides. We reviewed the intrinsic and environmental factors and pathogenic mechanisms that affect the occurrence and development of NAFLD, and summarized the influences of exercise, drugs, diet, and tea drinking on NAFLD. On this basis, we further analyzed the potential effects and molecular regulatory mechanisms of tea active compounds on NAFLD and proposed future development directions. This review hopes to provide novel insights into the development and application of tea active compounds in the prevention and treatment of NAFLD.

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Beverages and Non-alcoholic fatty liver disease (NAFLD): Think before you drink

2021

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Therapeutic Effects of Green Tea on Nonalcoholic Fatty Liver Disease in 10-16-Year-Old Children

Cited by 4 publications

References 0 publications

Plant‐Based Foods and Their Bioactive Compounds on Fatty Liver Disease: Effects, Mechanisms, and Clinical Application

Plant‐Based Foods and Their Bioactive Compounds on Fatty Liver Disease: Effects, Mechanisms, and Clinical Application

Regulatory Effects and Molecular Mechanisms of Tea and Its Active Compounds on Nonalcoholic Fatty Liver Disease

Beverages and Non-alcoholic fatty liver disease (NAFLD): Think before you drink

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