Therapeutic effects of hyaluronate injections in patients with chronic painful shoulder: A meta‐analysis of randomized controlled trials

Abstract

Objective. To elucidate the therapeutic efficacy and safety of injection of hyaluronate (HA) for chronic painful shoulder. Methods. The meta-analysis comprised randomized controlled trials (RCTs) that compared the efficacy of HA injections with that of a placebo. Articles were retrieved through systematic searches of databases, including Medline, EMBase, and Japana Centra Revuo Medicina. The outcome end points were classified into 5 categories: pain, shoulder range of motion (ROM), total functional score, comparison between HA and steroid injections, and HA safety. The primary outcome measures of the efficacy of HA injections were the standardized mean differences (SMDs) and the relative risk (RR) or odds ratio (OR) between HA and placebo groups. Conclusion. This meta-analysis confirms that HA injection is effective in relief of pain and is a safe alternative therapy for chronic painful shoulder.

Management of frozen shoulder: a systematic review and cost-effectiveness analysis.

“…The review concluded that sodium hyaluronate injection was modestly more effective than steroid injection for function and there was an improvement in pain and function compared with placebo. 116 …”

“…We are aware of three systematic reviews that have been published since our assessment started: one of corticosteroid injections compared with physiotherapy for frozen shoulder; 115 one of sodium hyaluronate injection for chronic painful shoulder; 116 and one of conservative and surgical interventions for frozen shoulder. 117 A guideline based on a systematic review has also recently been published focusing on diagnosis, assessment and physiotherapy management of frozen shoulder.…”

Does hyaluronate injection work in shoulder disease in early stage? A multicenter, randomized, single blind and open comparative clinical study

“…In the shoulder joint, recent studies reported good clinical outcomes of an intra-articular or subacromial hyaluronic acid injection for various painful shoulder diseases. 1,6,8,10,11,[19][20][21] Shibata et al 21 described the clinical outcome of an intraarticular hyaluronate injection for 78 shoulders with a rotator cuff tear. They reported that the effective rates in the hyaluronate and steroid groups were 39.5% and 35%, respectively.…”

Acute pain intensity in men and women after septoplasty

“…Problem of pain assessment widely discussed in abdominal surgery, traumatology, orthopedics etc [1][2][3][4][5]. Recently this point calls for consideration in otolaryngology, particularly in nasal cavity surgery [6][7][8][9][10].…”