Therapeutic Effects of <i>Turnera diffusa</i> Extract Against Amitriptyline-Induced Toxic Hepatic Inflammation

Hasan, Ahmed F.; Mutar, Thulfiqar Fawwaz; Tousson, Ehab; Felemban, Shatha Ghazi

doi:10.3844/ojbsci.2021.395.408

Cited by 7 publications

(3 citation statements)

References 53 publications

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“…In addition, they noted an improvement in the percentage of amitriptyline-induced DNA damage, evidenced by a significant reduction in DNA tail length in a comet assay in the T. diffusa-administered groups. The histopathological analysis revealed hepatocyte destruction, congestion with cellular infiltrate, and necrosis in the liver of amitriptylinetreated rats, whereas liver tissue from the co-and post-T. diffusa-administered groups showed a slight improvement in hepatocyte structure and only slight congestion [40].…”

Section: Hepatoprotectionmentioning

confidence: 90%

Bioactivity of the Genus Turnera: A Review of the Last 10 Years

Parra-Naranjo,

Delgado-Montemayor,

Salazar-Aranda

et al. 2023

Pharmaceuticals

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Turnera is a genus of plants whose biological activity has been widely studied. The importance of this genus, particularly Turnera diffusa, as a source of treatment for various conditions is evidenced by the large number of new studies that have evaluated its biological activity. Accordingly, the objective of this review was to compile the information published in the last ten years concerning the biological activities reported for Turnera spp. The present work includes 92 publications that evaluate 29 bioactivities and toxicological and genotoxic information on five species of this genus. Among the pharmacological effects reported, the antioxidant, hepatoprotective, neuroprotective, hypoglycemic, and aphrodisiac activities seem more promising. Phytochemicals and standardized plant extracts could offer alternative therapeutic remedies for various diseases. Although several flavonoids, cyanogenic glycosides, monoterpenoids, triterpenoids, and fatty acids have been isolated for Turnera plants, future research should focus on the identification of the main active principles responsible for these pharmacological activities, as well as to perform clinical trials to support the laboratory results.

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Section: Hepatoprotectionmentioning

confidence: 90%

Bioactivity of the Genus Turnera: A Review of the Last 10 Years

Parra-Naranjo,

Delgado-Montemayor,

Salazar-Aranda

et al. 2023

Pharmaceuticals

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“…The activity of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and serum total protein concentration has been identified by spectrophotometry using commercial kits (Hasan et al 2021).…”

Section: Biochemical Assaymentioning

confidence: 99%

Effect of treatment with essential oils on the liver toxicity induced by Ehrlich ascites carcinoma in female mouse model

Hameed,

Hasan,

Razooki

et al. 2024

Egyptian Journal of Cancer and Biomedical Research

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Background: Essential oils (SO) are organic substances that are extracted from plant parts, which have been thought to have anti-cancer characteristics. Aim: To investigate the potential protective effects of SO against liver toxicity induced in EAC-bearing female mice. Materials and Methods: Forty female mice were equally divided into four groups (Gps). Gp1 was served as control, Gp2 was treated with SO, Gp3 was inoculated with EAC, and Gp4 were concomitantly treated with EAC + SO. Results: Data showed that the treatment of EAC-bearing mice with SO led to an amelioration of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) activities. SO treatment also induced increases in the total protein levels as compared to EAC group. There was a significant improvement in the expression of GFAP protein in brain and liver tissues in the EAC/SO treated group as compared to the EAC group. Conclusion: The current results indicate to the potential hepatoprotective effects of essential oils.

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“…The activity of AST and ALT and ALP were determined and Serum albumin was calculated using the suggested methodology, and total protein concentration was calculated using the suggested previous methodology [15]. Serum urea and creatinine concentration were measured using a commercial kit that Diamond, an Egyptian company, provided according to [16].…”

Section: Biochemical Assaysmentioning

confidence: 99%

Role of Vitamin B17 against Colitis Bearing Female Mice Induced Variations in Some Blood Parameters

Hasan,

Hameed,

Alyasiri

2024

ARRB

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Colorectal cancer is also the third most common cause of cancer-related death, and in the US, it ranks as the third most prevalent kind of cancer. The cells that produce mucus to lubricate the colon and rectum can be the source of colorectal cancer. Natural substances known as phytochemicals contain anti-oxidant, anti-inflammatory, and anti-tumor properties. These properties may be crucial for the treatment of a number of debilitating illnesses. The extract of vitamin B17, or amygdalin, is made from the kernels of apricots. Nitrilosides are naturally occurring compounds that contain cyanide. Natural substances called amygdalin have been utilized in traditional Chinese medicine to treat a wide range of illnesses. Its various pharmacological qualities include anti-inflammatory, antioxidant, antitussive, anti-asthmatic, and anti-ulcer effects. findings, When colitis mice were given acetic acid injections via the anal route, they had diarrhoea, obvious rectal bleeding, and weight loss.serum ALT, AST, and ALP values were higher in the colitis group than in the control and vitamin B17 groups. Conversely, there was a notable drop in the colitis group's blood albumin and total protein levels when compared to the control and vitamin B17 groups. In contrast, as compared to the colitis group, vitamin B17 therapy for colitis resulted in a substantial decrease in the levels of ALT, AST, and ALP and an increase in the levels of albumin and total proteins. Serum urea and creatinine levels were higher in the colitis group in comparison to the vitamin B17 and control groups. However, there is a significant decrease in serum urea and creatinine levels in treated colitis with vitamin B17 group when compared with the colitis group. Compared to the vitamin B17 and control groups, the colitis group had higher blood levels of potassium and sodium ions. On the other hand, compared to the colitis group, the treated colitis with vitamin B17 group had significantly lower blood levels of potassium and sodium ions. When compared to the control and vitamin B17 groups, the colitis group's RBC levels and HB% were considerably lower; however, vitamin B17 therapy for colitis regulates and improves these alterations. In contrast to the control and vitamin B17 groups, the colitis group's WBC and platelet counts considerably increased. Conversely, the colitis group's WBC and platelet counts fell when treated with vitamin B17.

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Therapeutic Effects of Turnera diffusa Extract Against Amitriptyline-Induced Toxic Hepatic Inflammation

Cited by 7 publications

References 53 publications

Bioactivity of the Genus Turnera: A Review of the Last 10 Years

Bioactivity of the Genus Turnera: A Review of the Last 10 Years

Effect of treatment with essential oils on the liver toxicity induced by Ehrlich ascites carcinoma in female mouse model

Role of Vitamin B17 against Colitis Bearing Female Mice Induced Variations in Some Blood Parameters

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