Therapeutic Effects of Intravenous Infusion of Hyperoxygenated Solution on Acute Haemorrhagic Shock in Rabbits

Abstract

Tissue anoxia is the main mechanism of the shock reaction. Here, the effect of hyperoxygenated solution (HOS) on acute haemorrhagic shock was studied in rabbits. At 60 min after shock, rabbits were infused intravenously with hyperoxygenated solution at 10 (HOS1 group) or 20 ml/kg (HOS2 group) or with Ringer's solution at 10 ml/kg (RS group). Compared with values before shock, values after shock were lower for mean arterial pressure (MAP), more negative for base excess (BE) and higher for blood lactate (BL) and blood viscosity. After infusion, MAP declined more slowly in the HOS1 and HOS2 groups than in the RS group. At 30 and 60 min after infusion, arterial partial pressure of oxygen (PaO 2 ) and oxygen saturation (SaO 2 ) were higher and BE was less negative in the HOS1 and HOS2 groups than in the RS group, BL was lower in the HOS1 and HOS2 groups than in the RS group, and PaO 2 and SaO 2 were higher in the HOS2 group than in the HOS1 group. It was concluded that HOS infusion can rectify changes in vital signs more effectively than Ringer's solution after acute haemorrhagic shock in rabbits.

Application of pulsed arterial resuscitation in a rabbit model of hemorrhagic shock

“…[1][2][3][4][5][6][7] However, while early mortality has been significantly reduced, long-term mortality rate remains high. The main causes of death secondary to hemorrhagic shock are tissue hypoperfusion, major bleeding, and reperfusion injury, which can lead to multiple organ dysfunction syndrome.…”

“…[2,4,14,16] Rectifying tissue edema caused by fluid overload is currently a popular topic in fluid resuscitation research. [1,15] In recent years, the available arterial puncture procedures have gradually become more sophisticated. The carotid artery is located relatively superficially, is close to the heart, and has many receptors involved in regulating blood circulation on its vessel walls.…”