Therapeutic effects of iontophoresis with gold nanoparticles in the repair of traumatic muscle injury

Rocha, Franciani Rodrigues da; Haupenthal, Daniela Pacheco dos Santos; Zaccaron, Rubya Pereira; Corrêa, Maria Eduarda Anastácio Borges; Tramontin, Natalia dos Santos; Fonseca, Jeandro Paes; Nesi, Renata Tiscoski; Müller, Alexandre Pastoris; Pinho, Ricardo A.; Paula, Marcos Marques da Silva

doi:10.1080/1061186x.2019.1652617

Cited by 13 publications

(11 citation statements)

References 69 publications

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“…Additionally, injected AuNPs used in conjunction with iontophoresis, a physiotherapy technique employing microcurrent stimulation, improved tissue morphology, reduced proinflammatory cytokines, and reduced oxidative stress in an in vivo traumatic skeletal muscle injury model. [ 160 ] Along with stimulating changes in cell membrane potential as a conductive material, mechanistic studies have revealed that AuNPs and gold‐silver alloy nanoparticles (Au‐AgNPs) activate the p38 mitogen‐activated protein kinase signaling pathway in myoblasts, which plays an important role in myogenic differentiation. [ 161 ] Although there remains a need for further exploration in the literature, the evidence present for other tissues as well as in the following works suggests that AuNPs hold potential as additives in SMTE constructs.…”

Section: Properties Of Gold Nanomaterialsmentioning

confidence: 99%

Nanomaterial Additives for Fabrication of Stimuli‐Responsive Skeletal Muscle Tissue Engineering Constructs

Farr

Hogan

Mikos

2020

Adv Healthcare Materials

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Volumetric muscle loss necessitates novel tissue engineering strategies for skeletal muscle repair, which have traditionally involved cells and extracellular matrix-mimicking scaffolds and have thus far been unable to successfully restore physiologically relevant function. However, the incorporation of various nanomaterial additives with unique physicochemical properties into scaffolds has recently been explored as a means of fabricating constructs that are responsive to electrical, magnetic, and photothermal stimulation. Herein, several classes of nanomaterials that are used to mediate external stimulation to tissue engineered skeletal muscle are reviewed and the impact of these stimuli-responsive biomaterials on cell growth and differentiation and in vivo muscle repair is discussed. The degradation kinetics and biocompatibilities of these nanomaterial additives are also briefly examined and their potential for incorporation into clinically translatable skeletal muscle tissue engineering strategies is considered. Overall, these nanomaterial additives have proven efficacious and incorporation in tissue engineering scaffolds has resulted in enhanced functional skeletal muscle regeneration. 1. Introduction: Necessity for Stimuli-Responsive Constructs for Skeletal Muscle Tissue Engineering Volumetric muscle loss (VML) occurs when more than 20% of a muscle is lost, the point at which endogenous mechanisms for skeletal muscle self-repair are overcome. [1] VML frequently

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Section: Properties Of Gold Nanomaterialsmentioning

confidence: 99%

Nanomaterial Additives for Fabrication of Stimuli‐Responsive Skeletal Muscle Tissue Engineering Constructs

Farr

Hogan

Mikos

2020

Adv Healthcare Materials

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“… Reduced proinflammatory and oxidative stress parameters, preserved the morphology, and improved the locomotor response and pain symptoms. Da Rocha et al 85 AuNPs, 20 nm and 2.5, 7.0 and 21 mg/kg. Production of oxidants, markers of oxidative damage, and activity of the antioxidant system; In vivo: Gastrocnemius muscle MDX of mice Reduced morphological changes and reduced inflammatory and oxidative stress markers.…”

Section: Introductionmentioning

confidence: 99%

“…In this sense, several recent studies have suggested the use of AuNPs for inflammatory and redox control in muscle injury models. 75 , 82 , 85 …”

Section: Introductionmentioning

confidence: 99%

“…The dosages used are also varied, with a predominance of 20 mg/kg. 85 , 86 , 94 , 95 Raimondo and Mooney 15 analyzed the effects of the injectable application of 30, 60 and 100 nm AuNPs conjugated to IL4 on the regeneration of the tibialis anterior muscle of C57BL/6J female mice after an ischemic injury model and revealed that the use of these nanoparticles favors the polarization of macrophages M1 to M2 and increases muscle regeneration, strength and contraction speed. AuNP rods at 30 nm (diameter) and 4500 nm (length) were added to hydrogel and applied to the temporal muscle of Sprague-Dawley rats, and the results showed better actin filament restructuring, greater myosin formation, and less fibrosis.…”

Section: Introductionmentioning

confidence: 99%

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Gold Nanoparticle-Based Therapy for Muscle Inflammation and Oxidative Stress

Pinho¹,

Haupenthal²,

Fauser³

et al. 2022

JIR

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Proinflammatory cytokines and reactive oxygen species are released after muscle damage, and although they are necessary for the muscle regeneration process, an excess of these substances leads to the destruction of biomolecules and impairment of the repair system. Several drugs have emerged in recent years to control the muscle inflammatory response, and studies have shown that gold nanoparticles (AuNPs) have anti-inflammatory and antioxidant properties. This review reveals the effects of AuNPs on the inflammatory and redox mechanisms of muscles. We assessed the results of several studies published in different journals over the last 20 years, with a focus on the effects of AuNPs on possible aspects of muscle regeneration or recovery, namely, inflammatory processes and redox system mechanisms. A systematic database search was conducted using PubMed, Medline, Bireme, Web of Science, and Google Scholar to identify peer-reviewed studies from the 2000s. Combinations of keywords related to muscle damage, regeneration or repair, AuNPs, oxidative stress, and antioxidants were used in the search. This review did not address other variables, such as specific diseases or other biological effects; however, these variables should be considered for a complete understanding of the effects of AuNPs on skeletal muscles.

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“…Наночастицы В in vivo исследовании на крысах линии Wistar, где изучали модели мышечных и эпителиальных повреждений, было установлено преимущества использования наночастиц золота (НЧЗ) размером 20 нм. В группе лабораторных животных, которая получала ионофорез совместно с НЧЗ, показано значительные различия в параметрах воспаления и окислительного стресса по сравнению с другими группами [2].…”

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Актуальность Применения Нанотехнологий Для Регенерации Мышечной Ткани

Курочкин¹,

Лысенко²

2021

Débats Scientifiques Et Orientations Prospectives Du Développement Scientifique Volume2

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Therapeutic effects of iontophoresis with gold nanoparticles in the repair of traumatic muscle injury

Cited by 13 publications

References 69 publications

Nanomaterial Additives for Fabrication of Stimuli‐Responsive Skeletal Muscle Tissue Engineering Constructs

Nanomaterial Additives for Fabrication of Stimuli‐Responsive Skeletal Muscle Tissue Engineering Constructs

Gold Nanoparticle-Based Therapy for Muscle Inflammation and Oxidative Stress

Актуальность Применения Нанотехнологий Для Регенерации Мышечной Ткани

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