Therapeutic effects of long-term HBOT on Alzheimer's disease neuropathologies and cognitive impairment in APP/PS1 mice

Yang, Cui; Liu, Guangdong; Zeng, Xianrong; Xiang, Yang; Chen, Xi; Le, Weidong

doi:10.1016/j.redox.2023.103006

Cited by 4 publications

(1 citation statement)

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“…Severe hypoxia affects the central nervous system (CNS) by triggering neurovascular inflammation, oxidative stress, glial activation, impaired mitochondrial function, and cell death [1]. High O 2 therapy can elevate cerebral blood flow and improve cognitive behavioral performance by diminishing hypoxia involved in the pathogenesis of Alzheimer's disease (AD) [2,3]. Hypoxia-inducible factors (HIF1-3) regulate transcriptional responses to reduce O 2 availability [4].…”

Section: Introductionmentioning

confidence: 99%

Detrimental Roles of Hypoxia-Inducible Factor-1α in Severe Hypoxic Brain Diseases

Choi

2024

IJMS

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Hypoxia stabilizes hypoxia-inducible factors (HIFs), facilitating adaptation to hypoxic conditions. Appropriate hypoxia is pivotal for neurovascular regeneration and immune cell mobilization. However, in central nervous system (CNS) injury, prolonged and severe hypoxia harms the brain by triggering neurovascular inflammation, oxidative stress, glial activation, vascular damage, mitochondrial dysfunction, and cell death. Diminished hypoxia in the brain improves cognitive function in individuals with CNS injuries. This review discusses the current evidence regarding the contribution of severe hypoxia to CNS injuries, with an emphasis on HIF-1α-mediated pathways. During severe hypoxia in the CNS, HIF-1α facilitates inflammasome formation, mitochondrial dysfunction, and cell death. This review presents the molecular mechanisms by which HIF-1α is involved in the pathogenesis of CNS injuries, such as stroke, traumatic brain injury, and Alzheimer’s disease. Deciphering the molecular mechanisms of HIF-1α will contribute to the development of therapeutic strategies for severe hypoxic brain diseases.

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Section: Introductionmentioning

confidence: 99%

Detrimental Roles of Hypoxia-Inducible Factor-1α in Severe Hypoxic Brain Diseases

Choi

2024

IJMS

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The total withanolides from the leaves of Datura stramonium L. Improves Alzheimer’s disease pathology by restraining neuroinflammation through NLRP3/IL-1β/IL1R1/TOM 1 pathway

Li,

Pan,

Liu

et al. 2025

International Immunopharmacology

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New Insights on Hyperbaric Oxygen Therapy for Cancer

González,

Miranda-Massari,

Gonzalez

et al. 2024

J. Anal. Oncol.

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Hypoxia is a critical characteristic of malignant tumors and involves enhanced cell survival, angiogenesis, glycolytic metabolism, and metastasis. Hyperbaric oxygen treatment (HBOT) has been used to improve and cure disorders involving hypoxia and ischemia, HBOT enhances the amount of dissolved oxygen in the plasma and thereby increasing O2 delivery to the tissue. Studies on HBOT and cancer have mostly focused on whether enhanced oxygen may act as a promoter of cancer. As oxygen is believed to be required for all the major processes of wound healing, including angiogenesis, this particular idea would give the impression that HBOT will promote cancer growth and recurrence. Nevertheless, this is not the case since the use of HBOT in patients with malignancies should be considered safe and therapeutic. There is no evidence indicating that HBO neither acts as a stimulator of tumor growth nor as an enhancer of recurrence. On the other hand, there is evidence that implies that HBO has tumor-inhibitory effects, this manuscript pretends to expand our knowledge on the effect and the mechanisms behind tumor oxygenation by HBOT.

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Therapeutic effects of long-term HBOT on Alzheimer's disease neuropathologies and cognitive impairment in APP/PS1 mice

Cited by 4 publications

References 50 publications

Detrimental Roles of Hypoxia-Inducible Factor-1α in Severe Hypoxic Brain Diseases

Detrimental Roles of Hypoxia-Inducible Factor-1α in Severe Hypoxic Brain Diseases

The total withanolides from the leaves of Datura stramonium L. Improves Alzheimer’s disease pathology by restraining neuroinflammation through NLRP3/IL-1β/IL1R1/TOM 1 pathway

New Insights on Hyperbaric Oxygen Therapy for Cancer

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