Therapeutic Effects of Nandrolone and Testosterone in Adult Male HIV Patients With AIDS Wasting Syndrome (AWS): A Randomized, Double-Blind, Placebo-Controlled Trial

Sardar, Partha; Jha, Ayan; Roy, Deeptarka; Majumdar, Uddalak; Guha, Pradipta; Roy, Sabyasachi; Banerjee, Ramtanu; Banerjee, Amit Kumar; Bandyopadhyay, Dipanjan

doi:10.1310/hct1104-220

Cited by 16 publications

(11 citation statements)

References 24 publications

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“…Information on the diaphragm in rodent models of ALS is limited and has mainly been obtained in the transgenic rat model (Holzbaur et al, 2006;Lladó et al, 2006;Lepore et al, 2010), and the NMJ fine structure has not been analyzed in these studies. Moreover, we investigated the effects of treatment with nandrolone on NMJs of mSOD1 diaphragm; this anabolic steroid is widely employed in the treatment of muscle wasting associated with several pathological conditions in humans (Adachi and Takayanagi, 2008;Macdonald et al, 2007;Sardar et al, 2010). Nandrolone is also still one of the anabolic steroids most frequently used as performance-enhancing drug by athletes, as well as by adolescent non-athletes, though prohibited by doping control regulations (Maravelias et al, 2005;Hemmersbach and Grosse, 2010).…”

Section: Introductionmentioning

confidence: 99%

Analysis of neuromuscular junctions and effects of anabolic steroid administration in the SOD1G93A mouse model of ALS

Cappello

Vezzoli

Righi

et al. 2012

Molecular and Cellular Neuroscience

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Section: Introductionmentioning

confidence: 99%

Analysis of neuromuscular junctions and effects of anabolic steroid administration in the SOD1G93A mouse model of ALS

Cappello

Vezzoli

Righi

et al. 2012

Molecular and Cellular Neuroscience

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“…[ 18 ] One study, with a Jadad score of 3, showed no change in weight or estimates of body fat (triceps and scapula skinfold thickness). [ 105 ] In studies of HIV-positive men with weight loss, 3 of 6 studies (all of which had Jadad scores of 4 or 5) showed an increase in weight with testosterone treatment,[ 99 , 101 , 106 ] and all 4 studies that measured muscle mass showed an increase. [ 41 , 99 – 101 ]…”

Section: Resultsmentioning

confidence: 99%

Treatment of Men for “Low Testosterone”: A Systematic Review

et al. 2016

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Testosterone products are recommended by some prescribers in response to a diagnosis or presumption of “low testosterone” (low-T) for cardiovascular health, sexual function, muscle weakness or wasting, mood and behavior, and cognition. We performed a systematic review of 156 eligible randomized controlled trials in which testosterone was compared to placebo for one or more of these conditions. We included studies in bibliographic databases between January 1, 1950 and April 9, 2016, and excluded studies involving bodybuilding, contraceptive effectiveness, or treatment of any condition in women or children. Studies with multiple relevant endpoints were included in all relevant tables. Testosterone supplementation did not show consistent benefit for cardiovascular risk, sexual function, mood and behavior, or cognition. Studies that examined clinical cardiovascular endpoints have not favored testosterone therapy over placebo. Testosterone is ineffective in treating erectile dysfunction and controlled trials did not show a consistent effect on libido. Testosterone supplementation consistently increased muscle strength but did not have beneficial effects on physical function. Most studies on mood-related endpoints found no beneficial effect of testosterone treatment on personality, psychological well-being, or mood. The prescription of testosterone supplementation for low-T for cardiovascular health, sexual function, physical function, mood, or cognitive function is without support from randomized clinical trials.

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“…In both studies the intervention was associated with weight gain [ 18 , 19 ]. A randomised comparison of nandrolone, testosterone, or placebo for adult HIV patients with HIV wasting syndrome showed superior weight gain and improvement in BMI and quality of life from nandrolone [ 20 ]. Patients with COPD were given 50 mg fortnightly for 4 doses with improvement of muscle function and exercise capacity.…”

Section: Discussionmentioning

confidence: 99%

Anabolic Steroid Use for Weight and Strength Gain in Critically Ill Patients: A Case Series and Review of the Literature

Anstey

Desai

Torre

et al. 2018

Case Reports in Critical Care

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Background An important long-term complication of critical illness is significant weakness and its resulting functional impairment. Recent advances have aimed to prevent critical illness weakness via early mobilisation of patients, minimising sedation, and optimising nutrition. One other potential treatment may be to provide anabolic support in the recovery phase, especially as patients have decreased levels of anabolic hormones. Case Presentation We describe a case series of 4 patients who had either (1) profound critical illness myopathy and (2) profound weight loss. All patients were already receiving appropriate nutritional support and physiotherapy. All patients had functional improvements in their muscle strength. Conclusions For patients in the recovery phase of critical illness, we provide examples of when anabolic steroid supplementation may assist the treating clinicians in rehabilitating their patients who are still in the Intensive Care Unit. We discuss patient selection and the current supporting literature for anabolic supplementation in critically ill patients.

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Therapeutic Effects of Nandrolone and Testosterone in Adult Male HIV Patients With AIDS Wasting Syndrome (AWS): A Randomized, Double-Blind, Placebo-Controlled Trial

Abstract: Our trial demonstrates the superior therapeutic effects of nandrolone in male AWS patients, including the androgen deficient.

Cited by 16 publications

References 24 publications

Analysis of neuromuscular junctions and effects of anabolic steroid administration in the SOD1G93A mouse model of ALS

Analysis of neuromuscular junctions and effects of anabolic steroid administration in the SOD1G93A mouse model of ALS

Treatment of Men for “Low Testosterone”: A Systematic Review

Anabolic Steroid Use for Weight and Strength Gain in Critically Ill Patients: A Case Series and Review of the Literature

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