Therapeutic Effects of Omega-3 Fatty Acids on Chronic Kidney Disease-Associated Pruritus: a Literature Review

Treatment of Uremic Pruritus: A Systematic Review

“…9 Five previous systematic reviews have attempted to evaluate individual treatments for uremic pruritus. [65][66][67][68][69] These reviews have addressed the efficacy of gabapentin, 65 acupuncture, 66 ondansetron, 67 capsaicin, 68 and omega-3 fatty acids. 69 The review of gabapentin in hemodialysis patients by Lau et al 65 included 7 studies with a total of 179 patients: RCTs, quasi-RCTs, observational studies, open-label studies, and retrospective studies were included.…”

“…The authors concluded that there was a lack of evidence to support the use of acupuncture for uremic pruritus. Panahi et al 69 reviewed the literature on omega-3 fatty acids on uremic pruritus. They included all prospective English-language studies.…”

Bioactive food and exercise in chronic kidney disease: Targeting the mitochondria

“…There was no significant change in muscle mitochondrial respiration rates, but the results pointed towards a reduction in ROS production. Only a handful of small studies have investigated the potential beneficial effects of PUFA in CKD . Interestingly, randomized controlled trials comparing the effect of omega‐3 supplement of both omega‐6 and omega‐9, as compared to placebo supplementation, have shown significant improvements of pruritus in CKD …”

“…Only a handful of small studies have investigated the potential beneficial effects of PUFA in CKD. 79 Interestingly, randomized controlled trials comparing the effect of omega-3 supplement of both omega-6 and omega-9, as compared to placebo supplementation, have shown significant improvements of pruritus in CKD. 79 Coumestrol is a polyphenol with oestrogen properties found in raw clover sprouts, red clover, alfaalfa, soybeans, legumes, Brussel sprouts and spinach.…”

“…79 Interestingly, randomized controlled trials comparing the effect of omega-3 supplement of both omega-6 and omega-9, as compared to placebo supplementation, have shown significant improvements of pruritus in CKD. 79 Coumestrol is a polyphenol with oestrogen properties found in raw clover sprouts, red clover, alfaalfa, soybeans, legumes, Brussel sprouts and spinach. This bioactive compound might elicit anticancer effects by affecting viability and mitochondrial functions and provoking apoptosis by inhibition of PI3K/AKT and activation of MAPKs (ERK1/ 2 and JNK).…”