Therapeutic effects of peripheral magnetic stimulation on traumatic brachial plexopathy: Clinical and neurophysiological study

Khedr, Eman M.; Ahmed, Mohamed A.; Alkady, Eman A.M.; Mostafa, Mohammed Mahmoud; Said, Hatem G.

doi:10.1016/j.neucli.2011.11.003

Cited by 29 publications

(44 citation statements)

References 18 publications

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“…The reported beneficial effects of high‐induction electromagnetic field on acute and persistent pain prompted us to further explore whether LF‐EMF may be able to influence some of the known prototypical nociceptor‐specific ion channels. As an example, we have selected the transient receptor potential ankyrin subtype 1 (TRPA1) which is an excitatory ion channel expressed by nociceptive neurons of the dorsal root and trigeminal ganglia.…”

Section: Resultsmentioning

confidence: 99%

“…High‐induction electromagnetic field applied peripherally over a muscle or spinal nerve roots is capable of improving sensorimotor impairments and reducing acute and persistent pain . Proprioceptive as well as superficial cutaneous and nociceptive afferents may be recruited in these processes, although the latter are generally thought to be less involved .…”

Section: Introductionmentioning

confidence: 99%

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Acute exposure to high‐induction electromagnetic field affects activity of model peripheral sensory neurons

Průcha

Krůšek

Dittert

et al. 2017

J Cellular Molecular Medi

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Exposure to repetitive low‐frequency electromagnetic field (LF‐EMF) shows promise as a non‐invasive approach to treat various sensory and neurological disorders. Despite considerable progress in the development of modern stimulation devices, there is a limited understanding of the mechanisms underlying their biological effects and potential targets at the cellular level. A significant impact of electromagnetic field on voltage‐gated calcium channels and downstream signalling pathways has been convincingly demonstrated in many distinct cell types. However, evidence for clear effects on primary sensory neurons that particularly may be responsible for the analgesic actions of LF‐EMF is still lacking. Here, we used F11 cells derived from dorsal root ganglia neurons as an in vitro model of peripheral sensory neurons and three different protocols of high‐induction magnetic stimulation to determine the effects on chemical responsiveness and spontaneous activity. We show that short‐term (<180 sec.) exposure of F11 cells to LF‐EMF reduces calcium transients in response to bradykinin, a potent pain‐producing inflammatory agent formed at sites of injury. Moreover, we characterize an immediate and reversible potentiating effect of LF‐EMF on neuronal spontaneous activity. Our results provide new evidence that electromagnetic field may directly modulate the activity of sensory neurons and highlight the potential of sensory neuron‐derived cell line as a tool for studying the underlying mechanisms at the cellular and molecular level.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Acute exposure to high‐induction electromagnetic field affects activity of model peripheral sensory neurons

Průcha

Krůšek

Dittert

et al. 2017

J Cellular Molecular Medi

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show abstract

“…However, no significant difference was found in VAS, which was measured to assess the degree of hip pain, between the two groups. Although a few studies reported that rPMS might reduce the musculoskeletal pain, such the effect occurred when rPMS was applied to the tender point or the proximal part of the nerve to the painful areas [ 22 30 ]. But the reason why there is no difference in our study could be because rPMS was applied not to the tender point but to the motor point.…”

Section: Discussionmentioning

confidence: 99%

Effects of Repetitive Peripheral Magnetic Stimulation Over Vastus Lateralis in Patients After Hip Replacement Surgery

et al. 2018

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ObjectiveTo investigate the effects of repetitive peripheral magnetic stimulation (rPMS) on the vastus lateralis (VL) in the early stage after hip replacement surgery.MethodsTwenty-two patients who underwent hip replacement after proximal femur fracture were included in this study. After hip surgery, the experimental group was applied with 15 sessions of 10 Hz rPMS over the VL 5 times per week for 3 weeks, while the control group took sham stimulation. All patients were also given conventional physical therapy. The VL strength was measured with the root mean square (RMS) value of the VL with surface electromyography technique. The ratio of RMS values between fractured and unfractured legs and tandem stand test were used to assess standing balance. Usual gait speed was measured to evaluate gait function. Pain in two groups was assessed with visual analog scale (VAS).ResultsBoth RMS value of the VL and the ratio of RMS values after rPMS were significantly improved (p<0.05). Also, tandem standing time and usual gait speed in rPMS group were dramatically increased (p<0.05). However, no significant difference in VAS was found between the two groups after 3 weeks.ConclusionrPMS on the VL improved muscle strength, standing balance and gait function in the early stage after hip surgery. Therefore, rPMS could be applied to patients who cannot take electrical stimulation due to pain and an unhealed wound.

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“…Centrally, high frequency (>1Hz) transcranial magnetic stimulation (TMS) at the motor cortex or prefrontal cortices can produce analgesic benefits for various neuropathic pain conditions [Leung et al, ]. Peripherally, although dynamic magnetic flux use for pain relief is still limited, initial publications have suggested this technology can successfully be applied to treat pain of peripheral nerve origins as well [Smania et al, ; Weintraub and Cole, ; Khedr et al, ]. Aside from its non‐invasiveness, treatment involving dynamic magnetic flux requires no skin contact with potentially longer duration of relief, making it a perfect candidate for treating PTP‐NP.…”

Section: Introductionmentioning

confidence: 99%

Effect of low frequency transcutaneous magnetic stimulation on sensory and motor transmission

Leung

Shukla

Lee

et al. 2015

Bioelectromagnetics

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Peripheral nerve injury diminishes fast conducting large myelinated afferent fibers transmission but enhances smaller pain transmitting fibers firing. This aberrant afferent neuronal behavior contributes to development of chronic post-traumatic peripheral neuropathic pain (PTP-NP). Non-invasive dynamic magnetic flux stimulation has been implicated in treating PTP-NP, a condition currently not adequately addressed by other therapies including transcutaneous electrical nerve stimulation (TENS). The current study assessed the effect of low frequency transcutaneous magnetic stimulation (LFTMS) on peripheral sensory thresholds, nerve conduction properties, and TENS induced fast afferent slowing effect as measured by motor and sensory conduction studies in the ulnar nerve. Results indicated sham LFTMS with TENS (Sham + TENS) significantly (P = 0.02 and 0.007, respectively) reduces sensory conduction velocity (CV) and increases sensory onset latency (OL), and motor peak latency (PL) whereas, real LFTMS with TENS (Real + TENS) reverses effects of TENS on sensory CV and OL, and significantly (P = 0.036) increases the sensory PL. LFTMS alone significantly (P < 0.05) elevates sensory PL and onset-to-peak latency. LFTMS appears to reverse TENS slowing effect on fast conducting fibers and casts a selective peripheral modulatory effect on slow conducting pain afferent fibers.

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Therapeutic effects of peripheral magnetic stimulation on traumatic brachial plexopathy: Clinical and neurophysiological study

Cited by 29 publications

References 18 publications

Acute exposure to high‐induction electromagnetic field affects activity of model peripheral sensory neurons

Acute exposure to high‐induction electromagnetic field affects activity of model peripheral sensory neurons

Effects of Repetitive Peripheral Magnetic Stimulation Over Vastus Lateralis in Patients After Hip Replacement Surgery

Effect of low frequency transcutaneous magnetic stimulation on sensory and motor transmission

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