Therapeutic Effects of Rivastigmine and Alfa-Lipoic Acid Combination in the Charles Bonnet Syndrome: Electroencephalography Correlates

Hanoğlu, Lütfü; Yıldız, Sultan; Polat, Burcu; Demirci, Sema; Tavlı, Ahmet Mithat; Yılmaz, Nesrin Helvacı; Yuluğ, Burak

doi:10.2174/1574884711666161003153616

Cited by 11 publications

(6 citation statements)

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“…To date, we are not aware of previous investigations reporting a relation between complex visual hallucinations and resting state EEG features in DLB; this core symptom is frequently studied with event related responses 34 , 35 or transcranial stimulations 36 . However, previous EEG investigations in the Charles Bonnet syndrome (CBS) which is characterised by complex visual hallucinations in people with partial or severe blindness, have reported alterations in alpha and theta power 37 , 38 and this agrees with our results. Nevertheless, we must also take into account that our multiple linear regression results are uncorrected, and thus these findings must be taken with caution.…”

Section: Discussionsupporting

confidence: 93%

Electroencephalographic derived network differences in Lewy body dementia compared to Alzheimer’s disease patients

Peraza

Cromarty

Kobeleva

et al. 2018

Sci Rep

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Dementia with Lewy bodies (DLB) and Alzheimer’s disease (AD) require differential management despite presenting with symptomatic overlap. Currently, there is a need of inexpensive DLB biomarkers which can be fulfilled by electroencephalography (EEG). In this regard, an established electrophysiological difference in DLB is a decrease of dominant frequency (DF)—the frequency with the highest signal power between 4 and 15 Hz. Here, we investigated network connectivity in EEG signals acquired from DLB patients, and whether these networks were able to differentiate DLB from healthy controls (HCs) and associated dementias. We analysed EEG recordings from old adults: HCs, AD, DLB and Parkinson’s disease dementia (PDD) patients. Brain networks were assessed with the minimum spanning tree (MST) within six EEG bands: delta, theta, high-theta, alpha, beta and DF. Patients showed lower alpha band connectivity and lower DF than HCs. DLB and PDD showed a randomised MST compared with HCs and AD in high-theta and alpha but not in DF. The MST randomisation in DLB and PDD reflects decreased brain efficiency as well as impaired neural synchronisation. However, the lack of network topology differences at the DF between all dementia groups and HCs may indicate a compensatory response of the brain to the neuropathology.

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Section: Discussionsupporting

confidence: 93%

Electroencephalographic derived network differences in Lewy body dementia compared to Alzheimer’s disease patients

Peraza

Cromarty

Kobeleva

et al. 2018

Sci Rep

View full text Add to dashboard Cite

show abstract

“…To date, we are not aware of previous investigations reporting a relation between complex visual hallucinations and resting state EEG features in DLB; this core symptom is frequently studied with event related responses (25, 26) or transcranial stimulations (27). However, previous EEG investigations in the Charles Bonnet syndrome (CBS) which is characterised by complex visual hallucinations in persons with partial or severe blindness, have reported alterations in alpha and theta power in CBS patients (28, 29) and this agrees with our results. Nevertheless, we must also take into account that our multiple linear regression results are uncorrected, and thus these findings must be taken with caution.…”

Section: Discussionsupporting

confidence: 93%

Evidence of compensation in the brain networks of Lewy body dementia and Alzheimer’s disease patients

Peraza

Cromarty

Kobeleva

et al. 2017

Preprint

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Dementia with Lewy bodies (DLB) and Alzheimer’s disease (AD) require differential management despite presenting with symptomatic overlap. A human electrophysiological difference is a decrease of dominant frequency (DF) −the highest power frequency between 4-15Hz– in DLB; a characteristic of Parkinsonian diseases. We analysed electroencephalographic (EEG) recordings from old adults: healthy controls (HCs), AD, DLB and Parkinson’s disease dementia (PDD) patients. Brain networks were assessed with the minimum spanning tree (MST) within six EEG bands: delta, theta, high-theta, alpha, beta and DF. Patients showed lower alpha band connectivity and lower DF than HCs. Lewy body dementias showed a randomised MST compared with HCs and AD in high-theta and alpha but not within the DF. The MST randomisation in DLB and PDD reflects decreased brain efficiency as well as impaired neural synchronisation. However, the lack of network topology differences at the DF indicates a compensatory response of the brain to the neuropathology.

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“…En iyi kabul gören hipotezlerden biri olan serbestleşme (releasing phenomena) teorisine göre aferent girdilerin yokluğu ya da baskılanması durumunda santral sinir sisteminde spontane aktivite serbest kalır ve halüsinasyonlar gelişir. Ayrıca bu hastalarda dış dünya gerçekliğinin takibini yapan frontal kaynaklı "gerçeklik izleme" mekanizmalarının da bozulmuş olabileceğini düşünülmektedir (12). Zihnin bir ürünü olan bu halüsinasyonlar hasta kişilerde gerçeklik algısından ayırt edilememektedir (13,14).…”

Section: Cbsunclassified

Charles Bonnet Syndrome Prevelance in Patients with Low Visual Acuity

Tanrıverdi¹,

Erdur²,

Kocabora³

et al. 2019

btd

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Objective: Investigation of the prevalence of Charles Bonnet syndrome (CBS) among cases with low visual acuity. Methods: Patients admitted to İstanbul Medipol University Ophthalmology Clinic were investigated retrospectively from the outpatient clinic records. Patients with best corrected visual acuity of 0.3 or less were noted in the screening results, and were examined for CBS at the next follow-up examinations. Visual acuity measurements were done according to the Snellen chart. Patients with schizophrenia, depression and alcohol use were not included in the study. Only cases with complex visual hallucinations were evaluated as CBS. Patients with simple visual hallucinations such as lightning flashes or light rays were not considered to be CBS. Results: As a result of the investigation, 208 cases compliant with visual loss were detected. In the follow-up examinations of these patients, there CBS findings were observed in 12 patients. The mean age of these cases was 71±1.4 (between 61-77) years. Seven patients (58.3%) were female and 5 patients (41.7%) were male. Conclusion: CBS is a relatively common disease which should not be underestimated among low vision patients. We think that the diagnosis of the disease is extremely important for avoiding the medico-social problems due to hallucinations as well as the negative conditions caused by the existing ocular diseases of these group of patients.

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Therapeutic Effects of Rivastigmine and Alfa-Lipoic Acid Combination in the Charles Bonnet Syndrome: Electroencephalography Correlates

Cited by 11 publications

References 0 publications

Electroencephalographic derived network differences in Lewy body dementia compared to Alzheimer’s disease patients

Electroencephalographic derived network differences in Lewy body dementia compared to Alzheimer’s disease patients

Evidence of compensation in the brain networks of Lewy body dementia and Alzheimer’s disease patients

Charles Bonnet Syndrome Prevelance in Patients with Low Visual Acuity

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