“…After checking duplicates and screening titles and abstracts, 509 full-texts were further read. As a result, 48 RCTs, published from 1992 to 2020, involving 3,778 patients with VCI met the eligible criteria and were synthesized in the final quantitative meta-analysis (Huang et al, 1992;Mo et al, 2000a,b;Zhao et al, 2000Zhao et al, , 2009Jiang et al, 2003Jiang et al, , 2019Liu et al, 2006;Niu and Liu, 2007;Chu et al, 2008;Liu Y. et al, 2008;Liu Z. B. et al, 2008;Zhang et al, 2008Zhang et al, , 2015Zhang et al, , 2019Chen et al, 2009Chen et al, , 2015Chen et al, , 2020Li et al, 2009Li et al, , 2019Meng et al, 2009Meng et al, , 2020Shi et al, 2009;Yin et al, 2011;Lin et al, 2012;Li P. et al, 2012;Li S. et al, 2012;Li W. et al, 2012;Teng and Lai, 2012;Pan and Ai, 2013;Zhao and Xu, 2013;Cao et al, 2014;Li and Jiao, 2014;Cui et al, 2015;Luo et al, 2015;Yang et al, 2016Yang et al, , 2019Tan et al, 2017;Wang and Wang, 2017a,b,c;Cheng et al, 2018;Feng et al, 2019;Hu et al, 2019;…”