Therapeutic effects of soluble dietary fiber consumption on type 2 diabetes mellitus

Abstract

Soluble dietary fiber (DF) reduces the risk of developing diabetes and may have therapeutic effects in patients with type 2 diabetes mellitus (DM2). The present study aimed to investigate the effect of soluble DF on metabolic control in patients with DM2. A total of 117 patients with DM2 between the ages of 40 and 70 were assessed. Patients were randomly assigned to one of two groups, and administered extra soluble DF (10 or 20 g/day), or to a control group (0 g/day) for one month. Blood glucose, serum insulin and connecting peptide (C-peptide) levels, and the insulin resistance index, as determined using the homeostatic model assessment method, were measured during fasting and up to 2-h postprandially prior to and following one month of treatment. Other measurements included serum levels of glycated albumin (GA), blood lipid profiles, and an analysis of the blood pressure, body weight and waist/hip ratio of all patients. Following intervention, the levels of 2-h blood glucose, fasting insulin and lipoprotein(a), and the insulin resistance index, were significantly improved in all groups. Furthermore, the fasting blood glucose, 2-h insulin, fasting C-peptide, 2-h C-peptide, GA and triglyceride (TG) levels were significantly improved in the soluble DF groups. The 20 g/day soluble DF group exhibited significantly improved fasting blood glucose and low-density lipoprotein levels, as well as a significantly improved insulin resistance index. In addition, 10 and 20 g/day soluble DF significantly improved the waist and hip circumferences and levels of TGs and apolipoprotein A. The results of the present study suggested that increased and regular consumption of soluble DF led to significant improvements in blood glucose levels, insulin resistance and metabolic profiles, without improving the secretory function of the islets of Langerhans, over a short-term intervention period in patients with DM2.

Glycemic Index, Starch, and Protein Digestibility in Tempeh Gembus Cookies

“…Fiber affects food's GI related with its role as a physical inhibitor in the digestive process. Fiber consumption in sufficient amounts will benefit the blood glucose management [22]. It corresponds with research that stated the increase in dietary fiber consumption is related to better GI control [23].…”

High hydrostatic pressure stabilized micronutrients and shifted dietary fibers, from insoluble to soluble, producing a low-glycemic index mango pulp

“…The increased SDF after HHP treatment of mango might have an important clinical impact. Although not evaluated in this study, SDF has been shown to delay gastric emptying and to slower glucose absorption rate both in healthy subjects and in patients with type 2 diabetes (Chen et al, 2016). Likewise, SDF has been associated with satiety induction in humans by modulating the gut microbiome and the neurotransmitters and hormones that act directly on the gut-brain-axis (Zhao et al, 2018).…”

“…In addition to postprandial glucose levels, other cardiometabolic risk factors have also been shown to be responsive to SDF supplementation in the diet. SDF consumption in patients with type 2 diabetes has demonstrated to decrease postprandial blood glucose and insulin levels (Chen et al, 2016;Yao et al, 2014), as well as fasting blood glucose, triglycerides, and LDL cholesterol levels (Yao et al, 2014).…”

Fiber consumption effect on non-communicable disease: how big is the impact?

“…Alba et al (2016) reported increase soluble fiber from Partially Hydrolysed Guar Gum (PHGG) on a normal diet towards type 2 diabetes patients and MetS improved cardiovascular and metabolic profiles by reducing WC, HbA1c, UAE and trans-FA. Routine increase and consumption of Dietary Fiber (DF) soluble causes a significant improvement in blood glucose levels, insulin resistance and metabolic profile, without improving the secretory function of Islets of Langerhans, during the short-term intervention period in DMT2 patients (Chen et al, 2016) According to Post et al (2012), interventions involving fiber supplementation for patients with type 2 diabetes mellitus can reduce fasting blood glucose and HbA1c. Metaanalysis studies proved increasing fiber intake also increased glycemic control, suggesting this should be considered to be a treatment of patients with type 2 diabetes (Silva et al, 2013).…”