Therapeutic effects of traditional Korean medicine, Jeechool-Whan in allergic rhinitis model

Abstract

Jeechool-Whan (JW) is a prescription of Ponciri Fructus Immaturus and Atractylodis Rhizoma Alba and improves the functions of the stomach and the spleen. Although it is said in Korean Medicine that the spleen and the stomach are the roots of the body's resistance, the meaning of 'improving the spleen and the stomach' is very comprehensive. Moreover, there are lots of drugs that are said to improve the spleen and the stomach, and the number of prescriptions using these drugs is huge. In this study, we focused on the new effect and mechanism of the JW on the ovalbumin (OVA)-induced allergic rhinitis (AR) model. The increased number of rubs and the increased levels of IgE and histamine in the OVA-sensitized mice were inhibited by JW administration. The balance of Th1/Th2 cytokine level was regulated by JW administration. The levels inflammatory proteins were decreased by JW administration in the nasal mucosa of the OVA-sensitized mice. Eosinophils and mast cells infiltration increased by OVAsensitization was also decreased in the JW-administered mice. In addition, JW inhibited caspase-1 activity in the same nasal mucosa tissue. In activated human mast cells, JW inhibited the receptor interacting protein-2, IκB kinase-β, nuclear factor-κB/Rel A, and caspase-1 activation. In conclusion, this study will be support the clear understanding of the concept of the spleen and the stomach in traditional Korean medicine as well as for a possibility of finding a cure for this AR in traditional medical treatments.

The Sound of a Buk (Korean Traditional Drum) Attenuates Anaphylactic Reactions by the Activation of Estrogen Receptor-β

“…Choi et al [27] reported that hesperidin reduced the expression of TNF-α by suppressing HIF-1α in mast cells. TNF-α is released from mast cells by degranulation and aggravates allergic symptoms by inducing neutrophil chemotaxis and the production of other inflammatory cytokines [28,29,30]. Our results show that Buk music down-regulated TNF-α protein levels, which suggests Buk music down-regulated TNF-α by inhibiting HIF-1 activation.…”

Effects of schizandrin on the expression of thymic stromal lymphopoietin in human mast cell line HMC-1

“…We used the methods of Moon et al (2012) and Oh et al (2012), using an easy-BLUE™ RNA extraction kit (iNtRON Biotech, Republic of Korea) and isolated the total RNA from HMC-1 cells in accordance with the manufacturer's specification. The concentrations of total RNA in the final elutes were determined by spectrophotometer.…”

Socioeconomic impact of traditional Korean medicine, Pyeongwee-San (KMP6) as an anti-allergic inflammatory drug

“…Hesperidin, an active component of KMP6 potently regulates stem cell factor (SCF)-induced migration through the hindering of SCF and c-kit binding in mast cells . Recently, we also reported that KMP6 has the regulatory effect in AR and AD animal model (Han et al, 2012;Oh et al, 2012a). However, it has not been sufficiently clarified how KMP6 and its active compound, hesperidin, modulate the responses of mast cells.…”