Therapeutic effects of Vernonia amygdalina on the expression of hormone and HER2 receptors in 7, 12-dimethylbenz(a)anthracene-induced breast tumours in obese and non-obese Wistar rats

Omisore, Adeleye Dorcas; Abiodun, Adeleke Adegboyega; Adeyemi, David; Zabdiel, Abijo Ayodeji; Jolayemi, Kehinde Akinyemi; Odedeyi, Akinola Ayodeji

doi:10.1016/j.phyplu.2022.100318

Cited by 4 publications

(1 citation statement)

References 27 publications

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“…The use of plants in herbal medicine is very old and is currently experiencing renewed interest among rural and urban populations [1][2][3]. According to the WHO, nearly 6377 species of plants are used in Africa, of which more than 400 are medicinal plants which constitute 90% of traditional medicine.…”

Section: Introductionmentioning

confidence: 99%

Optimization of Extraction Parameters, Total Polyphenols and Flavonoids Contents, and Antioxidant Activity of the Aqueous Extract of Vernonia amygdalina Leaves

Nabeel¹

2023

Preprint

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Section: Introductionmentioning

confidence: 99%

Optimization of Extraction Parameters, Total Polyphenols and Flavonoids Contents, and Antioxidant Activity of the Aqueous Extract of Vernonia amygdalina Leaves

Nabeel¹

2023

Preprint

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Vanillic acid ameliorates diethyl phthalate and bisphenol S‐induced oxidative stress and neuroinflammation in the hippocampus of experimental rats

Eteng,

Ugwor,

James

et al. 2024

J Biochem & Molecular Tox

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Long‐term adverse effects on human health are caused by exogenous compounds that alter the functions of biological systems, especially neuroendocrine disruptors like diethyl phthalate (DEP) and bisphenol S (BPS). Although vanillic acid (VA) has pertinent neuropharmacological characteristics, its effect against DEP + BPS‐induced neurotoxicity has not been explored. This study proposed that VA may offer protection against the neurotoxicity caused by DEP + BPS. Thirty male Wistar rats were randomly distributed across five groups: a control group receiving DMSO, a group exposed to a mixture of BPS and DEP, two BPS + DEP‐exposed groups treated with VA at doses of 25 mg/kg or 50 mg/kg, and a nonexposed group treated with 50 mg VA/kg. After 21 days, the hippocampal tissues were processed for biochemical analyses. Our results indicate that exposure to DEP + BPS upregulated neurosignaling mediators (NTPDase, ADA, MAO‐A, and Ca2+), inhibited others (AChE and Ca2+/Mg2+‐ATPase), decreased hippocampus antioxidants (GSH, GPx, CAT, and SOD), and elevated markers of oxidative stress/damage (NO, H2O2, MDA, and AOPP). AR, BAX, TNF‐α, BAK1, and IL‐1β expressions were upregulated, while IL‐10 and BDNF expressions were downregulated. NF‐κB and caspase‐3/9 pathways were also upregulated. Co‐treatment with vanillic acid remarkably precluded these neurotoxic outcomes by improving neurosignaling, augmenting antioxidant status, abrogating oxidative damage, inflammation (TNF‐α, IL‐1β), and apoptosis (BAX, BAK1, caspase‐3/9). Vanillic acid also restored IL‐10 and BDNF levels, thereby exhibiting neuroprotective effects, corroborated by histological examinations. We posit vanillic acid as a safe and effective therapeutic agent against neurotoxicity occasioned by exposure to neuroendocrine disruptors.

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The beneficial role of combinatorial spondias mombin and metformin treatments in Streptozotocin (STZ)-induced Pancreatic damage

Akwu,

Ajibade,

Abijo

et al. 2024

Food Chemistry Advances

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Therapeutic effects of Vernonia amygdalina on the expression of hormone and HER2 receptors in 7, 12-dimethylbenz(a)anthracene-induced breast tumours in obese and non-obese Wistar rats

Cited by 4 publications

References 27 publications

Optimization of Extraction Parameters, Total Polyphenols and Flavonoids Contents, and Antioxidant Activity of the Aqueous Extract of Vernonia amygdalina Leaves

Optimization of Extraction Parameters, Total Polyphenols and Flavonoids Contents, and Antioxidant Activity of the Aqueous Extract of Vernonia amygdalina Leaves

Vanillic acid ameliorates diethyl phthalate and bisphenol S‐induced oxidative stress and neuroinflammation in the hippocampus of experimental rats

The beneficial role of combinatorial spondias mombin and metformin treatments in Streptozotocin (STZ)-induced Pancreatic damage

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