Therapeutic Effects of Viscum album Combined with Garcinia kola against CCL4 Induced Liver Injury in Albino Rats

Emeji, Roseline; Gabriel, Tamuno-Emine Davies; Ndokiari, Bosia

doi:10.9734/ajbgmb/2019/v2i330060

Cited by 2 publications

(2 citation statements)

References 13 publications

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“…The syringe needle bevel was then placed into the mouth of the rat a bit laterally in a way to avoid the teeth which are located centrally. The content in the syringe was then emptied into the mouth of the rat gradually [23].…”

Section: Procedures For Administration Of Toxicantmentioning

confidence: 99%

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Study on the Therapeutic Benefits of Vitamin E after Paraquat Toxicity

Okolonkwo

Nyebuchi

Adjekuko

et al. 2022

JSRR

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The Paraquat (1, 1-dimethyl-4,4-bipyridlium dichloride) is a non-selective nitrogen herbicide that is used for broadleaf control of weed. It has been shown that paraquat is toxic to human and animal. Vitamin E (α-tocopherol) is a lipid soluble antioxidant found in all cellular membranes. It helps in protecting the cell against lipid peroxidation. It has been documented that vitamin E has a protective effect against PQ-induced hematological toxicity in albino rats. This study was carried out to evaluate the haematological effect of Vitamin E therapy on the chronic toxicity of paraquat in Albino rats. . A total of 200 male albino rats were used for the study. The 200 rats were divided into four main groups (A, B, C, D) and each group had 50 rats and was further subgrouped into two, having 25rats per subgroup. “A” group was not induced with paraquat while “B”, ‘C” and “D” groups were induced in increasing dose of 0.02g, 0.04g and 0.06g respectively. “A” group had two subgroups; “Ao” and “Ave” which represented the sub-group not treated with Vit E and the subgroup treated with Vit E (500mg) respectively. This design also applied to group “B”, “C” and “D”. Paraquat induction frequency was done every forth night for three month followed by weekly treatment for three months. The result showed a significant decrease in PCV, Hb, and TWBC count for group in the Ao, Bo, Co and Do at p<0.05 but no significant difference in the neutrophil and lymphocyte count. It also showed a significant increase in the Hb, and PCV of subgroups Ave, Bve, Cve and Dve at p<0.05 but no significant difference in the TWBC count and differentials. This suggest that Vitamin E supplementation had an ameliorative effect on the PCV and Hb values but no effect on the TWBC count and differentials on paraquat toxicity.

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Section: Procedures For Administration Of Toxicantmentioning

confidence: 99%

“…The blood samples were collected via cardiac puncture from the animals and sacrificed under 70% chloroform anesthesia into the Ethylenediaminetetra acetic acid (EDTA) specimen bottle and used for analysis of haematological parameters [23].…”

Section: Sample Collectionmentioning

confidence: 99%

Study on the Therapeutic Benefits of Vitamin E after Paraquat Toxicity

Okolonkwo

Nyebuchi

Adjekuko

et al. 2022

JSRR

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Biological Evaluation of Garcinia kola Heckel

Abdulrahman

Bradosty

Hama

et al. 2022

Advances in Pharmacological and Pharmaceutical Sciences

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Garcinia kola belongs to the Garcinia genus of the Clusiaceae family and Malpighiales order. It contains more than 180 members all over the globe. It is found all over Asia and in tropical African countries. In Africa, traditionally, G kola is used to manage and treat cancer, diabetes, malaria, analgesics, hypertension, and other numerous ailments. This review aimed to comprehensively update relevant information regarding the pharmacological potential of Garcinia kola. Electronic databases such as ScienceDirect, PubMed, Wiley, Google Scholar, Hindawi, and Springer extracted valuable information from original scientific research papers. Inclusion Criteria. Antioxidant, antimicrobial, antidiabetic, antibacterial, medications, antiviral, traditional medicine, ethnopharmacology, toxicity, cytotoxic action, chemical composition, mineral elements, GCMS analysis, and any other related phrases were used as filters to find studies. Exclusion Criteria. Data from questionable online sources, as well as thesis reports and review publications, were excluded from this investigation. The investigation revealed that seeds of G. kola are very efficient as antioxidant, antimicrobial, antidiabetic, antihypertension, antianalgesic, and anti-inflammatory. The study also found that too much consumption of the seeds caused low fertility and toxicity. However, the safety and efficacy of G. kola have not been wholly assessed in humans, and further well-designed clinical trials are needed to corroborate preclinical findings. The mechanism of action of the seed extract should be examined. The standard dose and safety of the seed should be established.

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Therapeutic Effects of Viscum album Combined with Garcinia kola against CCL4 Induced Liver Injury in Albino Rats

Cited by 2 publications

References 13 publications

Study on the Therapeutic Benefits of Vitamin E after Paraquat Toxicity

Study on the Therapeutic Benefits of Vitamin E after Paraquat Toxicity

Biological Evaluation of Garcinia kola Heckel

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