Therapeutic efficacy and bioaccumulation of albendazole in the treatment of tambaqui (
            <i>Colossoma macropomum</i>
            ) parasitized by acanthocephalan (
            <i>Neoechinorhynchus buttnerae</i>
            )

Cordeiro, Rafaelle Pereira; Braga, Patrícia Aparecida de Campos; Jonsson, Cláudio Martín; Brandão, Franmir Rodrigues; Chagas, Edsandra Campos; Reyes, Félix Guillermo Reyes

doi:10.1111/are.15677

Cited by 5 publications

(8 citation statements)

References 33 publications

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“…Brazilian legislative framework establishes that medicinal pharmaceutical products for veterinary use must be speci cally registered by MAPA, so that they can be prescribed for use in animals. In addition, to register a veterinary drug as antiparasitic, its e cacy must be greater than or equal to 90% (Cordeiro et al 2022). Therefore, the albendazole treatments evaluated in this study achieved the required MAPA e cacy.…”

Section: Discussionmentioning

confidence: 99%

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Albendazole is effective for controlling monogenean parasites of the gills of Piaractus brachypomus (Serassalmidae) and Leporinus macrocephalus (Anostomidae)

Negreiros

Souza

Lima

et al. 2022

Preprint

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Aquaculture is the fastest-growing food production industry both in Brazil and globally. Such growth has led to an increase in parasitic diseases such as those caused by monogeneans in farmed fish. Monogenean infection can cause high mortality among commercially farmed fish and therefore significant financial losses. The present study investigated the efficacy of albendazole in therapeutic baths against monogeneans of Piaractus brachypomus and Leporinus macrocephalus. For both fish, a 24h hourtherapeutic bath with albendazole concentrations of 150, 300 and 500 mg/L was tested against monogeneans in the gills. The baths had an efficacy ranging from 30.7 to 96.1% against monogeneans of P. brachypomus, and from 89.2 to 100% against monogeneans of L. macrocephalus. In P. brachypomus, the hepatosomatic index (HSI) in fish exposed to 150 mg/L of albendazole was higher than in fish exposed to 300 mg/L. The splenosomatic index (SSI) values in fish exposed to 150 mg/L of albendazole were lower than in fish exposed to 0 and 300 mg/L. In L. macrocephalus, the HSI and SSI values decreased in treatments with 150, 300 and 500 mg/L of albendazole. For L. macrocephalus, 150 mg/L de albendazole may be used to control and treat of infection by monogeneans, while in P. brachypomus, 500 mg/L of albendazole may be used in a 24 h bath.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Albendazole is effective for controlling monogenean parasites of the gills of Piaractus brachypomus (Serassalmidae) and Leporinus macrocephalus (Anostomidae)

Negreiros

Souza

Lima

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Brazilian legislative framework establishes that medicinal pharmaceutical products for veterinary use must be specifically registered by MAPA, so that they can be prescribed for use in animals. In addition, to register a veterinary drug as antiparasitic, its efficacy must be greater than or equal to 90% (Cordeiro et al, 2022). Therefore, the albendazole treatments evaluated in this study achieved the required MAPA efficacy.…”

Section: Discussionmentioning

confidence: 99%

“…Albendazole is a versatile anthelminthic that is rapidly oxidized to its pharmacologically active metabolite, albendazole sulfoxide, after administration. Since it is widely used around the world, despite it has not yet been regulated for application in fish farming, this anthelmintic has been studied (Cordeiro et al, 2022). However, it has not been assayed to determine its efficacy in controlling monogeneans of P. brachypomus and M. macrocephalus, both fish of great economic importance to aquaculture in Brazil.…”

Section: Introductionmentioning

confidence: 99%

Albendazole is effective for controlling monogenean parasites of the gills of Piaractus brachypomus (Serrasalmidae) and Megaleporinus macrocephalus (Anostomidae)

Negreiros

Souza

Lima

et al. 2022

Rev. Bras. Parasitol. Vet.

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Monogenean infestations can cause high mortality in farmed fish and therefore significant economic losses. The present study investigated the efficacy of albendazole in therapeutic baths against monogeneans of Piaractus brachypomus Cuvier, 1818 and Megaleporinus macrocephalus (Garavello & Britski, 1988). For both fish, a 24 hours therapeutic bath with albendazole concentrations of 150, 300 and 500 mg/L were tested against monogeneans from the gills. The baths had an efficacy from 61.4 ± 32.9 (95%CI=64.5) against monogeneans of P. brachypomus, and from 95.4 ± 5.6 (95%CI=10.9) against monogeneans of M. macrocephalus. In P. brachypomus, the hepatosomatic index (HSI) in fish exposed to 150 mg/L of albendazole was higher than in fish exposed to 300 mg/L. The splenosomatic index (SSI) values in fish exposed to 150 mg/L of albendazole were lower than in fish exposed to 300 mg/L. In M. macrocephalus, the HSI and SSI values decreased in treatments with 150, 300 and 500 mg/L of albendazole to control and treat infestations by monogeneans. For M. macrocephalus, 150 mg/L of albendazole can be used to control and treat infestations by monogeneans, while for P. brachypomus 500 mg/L of albendazole can be used in a 24 hours bath.

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“…The use of EC in medicated feed containing ABZ was reported for pacu (Piaractus mesopotamicus, Holmberg, 1887) (Busatto et al 2017) and tambaqui (Cordeiro et al 2022). However, the effect of coating medicated feed with EC on treatment efficacy and bioaccumulation of ABZ in edible fish tissue through the direct comparison of coated and uncoated feed has not yet been reported, and was thus analyzed in this study using tambaqui naturally parasitized with N. buttnerae.…”

mentioning

confidence: 99%

Effect of ethylcellulose coating of albendazole-medicated feed on the efficacy of acanthocephalosis treatment in naturally parasitized tambaqui (Colossoma macropomum)

CORDEIRO,

BRAGA,

JONSSON

et al. 2024

Acta Amaz.

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Coating medicated fish feed with a polymer minimizes the chances of drug leaching into the water. Tambaqui (Colossoma macropomum) is an economically important Amazonian fish frequently parasitized by the acanthocephalan Neoechinorhynchus buttnerae. In this study, we compared the effect of ethylcellulose (EC 0.75%) coating of feed medicated with the antihelminthic albendazole (ABZ 10 mg kg bw-1) and uncoated feed on treatment efficacy and bioaccumulation of ABZ in naturally parasitized tambaqui during 35 days. Treatment efficacy was 34% and 66% in fish fed uncoated and coated feed, respectively, but did not vary significantly among treatments. Total ABZ residue reached concentrations from 122.0 to 151.7 ng g-1, and did not vary significantly among treatments. The biomagnification factor was low, ranging from 0.0003 to 0.0004. EC coating did not significantly affect the efficacy of ABZ treatment and did not interfere with ABZ bioaccumulation in the edible tissue of tambaqui.

show abstract

Therapeutic efficacy and bioaccumulation of albendazole in the treatment of tambaqui ( Colossoma macropomum ) parasitized by acanthocephalan ( Neoechinorhynchus buttnerae )

Cited by 5 publications

References 33 publications

Albendazole is effective for controlling monogenean parasites of the gills of Piaractus brachypomus (Serassalmidae) and Leporinus macrocephalus (Anostomidae)

Albendazole is effective for controlling monogenean parasites of the gills of Piaractus brachypomus (Serassalmidae) and Leporinus macrocephalus (Anostomidae)

Albendazole is effective for controlling monogenean parasites of the gills of Piaractus brachypomus (Serrasalmidae) and Megaleporinus macrocephalus (Anostomidae)

Effect of ethylcellulose coating of albendazole-medicated feed on the efficacy of acanthocephalosis treatment in naturally parasitized tambaqui (Colossoma macropomum)

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