Therapeutic Efficacy of 1,927-nm Fractionated Thulium Laser Energy and Polydeoxyribonucleotide on Pattern Hair Loss

Abstract

Background and ObjectivesIntra-perifollicular polydeoxyribonucleotide (PDRN) injections result in clinical improvements in hair thickness and density in patients with pattern hair loss (PHL). The objective of this study is to evaluate the efficacy of combined treatment with a 1,927-nm fractionated thulium laser and PDRN injections for treatment of PHL. Materials and MethodsWe compared clinical outcomes in eight PHL patients treated with 12 sessions of combined treatment with thulium laser and PDRN injections to those in another eight PHL patients treated with 12 sessions of mesotherapy and PDRN injections. ResultsOne week after the final treatment session, patients treated with the thulium laser and PDRN showed clinical improvements in mean hair counts (20.4 ± 15.7%; p=0.005) and mean hair thickness (53.1 ± 31.1%; p <0.001), compared to baseline values. Patients treated with mesotherapy and PDRN also showed clinical improvements in mean hair counts (9.7 ± 7.4%; p=0.007) and mean hair thickness (16.1 ± 25%; p>0.05). Further statistical analysis showed that combined treatment with the thulium laser and PDRN injections resulted in greater improvement in hair thickness (p=0.029) than combined application of mesotherapy and PDRN, but not in hair counts (p>0.05). ConclusionUse of thulium laser energy in combination with PDRN injections for treatment of PHL results in remarkable improvements in hair thickness and density.

Improvement of Hair Graying during a Treatment of Male Pattern Hair Loss Using 1,927-nm Fractionated Thulium Laser Energy and Polydeoxyribonucleotide Injections

“…2 In our method, intra-perifollicular PDRN injections and topically applied KGF-containing growth factor solution could have exerted protective effects on melanocyte stem cells by supporting their antioxidative properties, which might have stimulated melanocyte stem cells to repopulate themselves. Overall, the thulium laser-induced tissue reactions, as well as the anti-oxidative effects of PDRN and KGF, could have supported and stimulated melanocyte stem cells to renew themselves, which eventually resulted in improvements in hair graying.…”

“…2 In addition, the patient was also satis- fied with unexpected improvement in hair graying. The slight improvement in hair graying was observed along the frontal hair line and vertex area (Fig.…”

“…The efficacy of the combined treatment for MPHL was published previously. 2 After obtaining written informed consent, the patient received 12 sessions of combined treatment with a 1,927-nm fractionated thulium laser (LASEMD TM ; Lutronic Corp., Goyang, Korea) and intra-perifollicular PDRN (Placentex ® integro; Mastelli Ltd., Sanremo, Italy) injections at weekly intervals. In each session, a total of about 120 shots of thulium laser energy was delivered to the scalp at a power of 3W and an energy of 2 mJ with a static operation mode.…”

Treatment of Melasma Using a Novel 1,927 nm Fractional Thulium Laser: A Retrospective Analysis of 68 Korean Patients

“…In the present study, heat damage could be expected to be confined to the epidermis in a fractionated pattern and this can explain the low rate of PIH since PIH is associated with the disruption of the dermoepidermal junction and inflammation in the upper dermis. 25 The thulium laser system used in the study has been described to create coagulation columns confined to the epidermis at low energy settings and be capable of creating coagulation zones extending from the epidermis through the upper dermis at higher power and pulse energy settings, 23 which clearly indicates that the depth of the 1,927 nm fractional laser treatment zone is determined by the energy setting. In melasma, the target pigments are located in the epidermis and a more conservative energy setting is suggested to adequately target epidermal pigments.…”

“…16,23 By targeting water as its chromophore, the laser induces a dense array of microscopic, columnar thermal zones of tissue injury, and subsequent "melanin shuttling" of underlying epidermal and dermal pigment coupled with remodeling of the pathologic dermis has been proposed as a possible mechanism. 24 Polder et al 18 treated fourteen patients with melasma via a combined fractional 1,550 nm and 1,927 nm fractional thulium fiber laser.…”