Therapeutic Efficacy of a Composition of Amphotericin B and Dialdehyde Dextran in Kidney Damage in Mice of Various Strains with Systemic Candidiasis

Pristavka, A. A.; Nadeev, A. P.; Travin, M. A.; Shkurupiy, V. A.

doi:10.1007/s10517-009-0409-2

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“…It could also be hypothesized that lower number of viable C. albicans captured by macrophages got into the brain, but they were more effi ciently eliminated from the blood by macrophages activated by OD, which promotes phagocytosis completion at the stage of phagosome-lysosome fusion [1]. It should be noted that under similar experimental conditions, the concentration of infi ltrates and granulomas and the therapeutic effect of C in the liver, lungs, kidney, and lymph nodes were suffi ciently higher than in the brain, probably due to different conditions for blood vessel crossing by C. albicans, macrophages, and C [2,3,11,14].…”

Section: Resultsmentioning

confidence: 99%

“…Drug transport across the blood-brain barrier (BBB) is also a problem in the treatment of mycoses. Higher efficacy of a composition (C) consisting of amphotericin B (amphB) and oxidized dextran (OD) compared to amphotericin alone, in the treatment of systemic candidiasis was previously shown [2,3,11,14].The aim of this study is to investigate structural changes in the brain of mice with generalized candidiasis after treatment with C. …”

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confidence: 99%

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Morphological Changes in the Brain of Mice with Systemic Candidiasis Treated with Composition of Amphotericin B and Oxidized Dextran

et al. 2011

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We observed morphological manifestation of encephalitis 3, 7, 10 and 28 days after intravenous infection of adult male CBA mice with Candida albicans. Compounds were administered intraperitoneally every other day starting from the next day postinfection. Untreated animals (100%) died over the period between days 18 and 20 postinfection; 60% animals receiving oxidized dextran alone survived by day 28 of observation. All animals treated with amphotericin B and composition of amphotericin B and oxidized dextran survived. On day 3 postinfection, the count of macrophage infiltrates and granulomas in the cerebral interstitium of mice treated with amphotericin B was equal to that in untreated mice, but was sufficiently lower in animals treated with the composition or oxidized dextran alone. On day 10, this index was similar in all groups and was approximately 5 times lower than in untreated animals on day 3. On day 28, macrophage infiltrates and granulomas were absent in the brain of all treated mice. These data suggest that oxidized dextran produced a therapeutic effect, which manifested earlier than the effect of amphotericin B and potentiated its effect, probably due to its competition with Candida albicans for mannose receptors on the brain-blood barrier endothelium.

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Section: Resultsmentioning

confidence: 99%

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confidence: 99%