Therapeutic efficacy of a synthetic epsin mimetic peptide in glioma tumor model: uncovering multiple mechanisms beyond the VEGF-associated tumor angiogenesis

Dong, Jerry; Saunders, Debra; Silasi‐Mansat, Robert; Yu, Lili; Zhu, Hua; Lupu, Florea; Towner, Rheal A.; Dong, Yunzhou; Chen, Hong

doi:10.1007/s11060-018-2766-z

Cited by 7 publications

(8 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To be able to selectively modify the trafficking of disease-relevant surface proteins will for example open up new avenues for targeted cancer therapies. A prominent example is the use of peptides blocking the Epsin-VEGFR2 interaction to impair tumor angiogenesis which inhibits tumor growth and metastasis in mouse models [332][333][334]. The selective inhibition of endocytosis could also prove useful in combination with cancer therapies, which exploit the antibody-based recognition of surface-localized tumor markers such as EGFR for the delivery of cytotoxic drugs.…”

Section: Discussionmentioning

confidence: 99%

Endocytic Adaptor Proteins in Health and Disease: Lessons from Model Organisms and Human Mutations

Tehran

López-Hernández

Maritzen

2019

Cells

View full text Add to dashboard Cite

Cells need to exchange material and information with their environment. This is largely achieved via cell-surface receptors which mediate processes ranging from nutrient uptake to signaling responses. Consequently, their surface levels have to be dynamically controlled. Endocytosis constitutes a powerful mechanism to regulate the surface proteome and to recycle vesicular transmembrane proteins that strand at the plasma membrane after exocytosis. For efficient internalization, the cargo proteins need to be linked to the endocytic machinery via adaptor proteins such as the heterotetrameric endocytic adaptor complex AP-2 and a variety of mostly monomeric endocytic adaptors. In line with the importance of endocytosis for nutrient uptake, cell signaling and neurotransmission, animal models and human mutations have revealed that defects in these adaptors are associated with several diseases ranging from metabolic disorders to encephalopathies. This review will discuss the physiological functions of the so far known adaptor proteins and will provide a comprehensive overview of their links to human diseases.

show abstract

Section: Discussionmentioning

confidence: 99%

Endocytic Adaptor Proteins in Health and Disease: Lessons from Model Organisms and Human Mutations

Tehran

López-Hernández

Maritzen

2019

Cells

View full text Add to dashboard Cite

show abstract

“…[ 9 ] A study revealed that a variety of mechanisms are found beyond the VEGF-related angiogenesis of tumors. [ 10 ] Hypoxia is one of the most important regulatory factors for the expression of VEGF. In the present study, RT-qPCR results revealed that the mRNA expression levels of Cyr61, CTGF, and VEGF in muscle tissues were higher in the PM and DM groups than in the control group.…”

Section: Discussionmentioning

confidence: 99%

Strobe

Ke-fu

Chen²,

Fan

et al. 2018

Medicine

View full text Add to dashboard Cite

This study aims to explore the roles of cysteine-rich protein 61 (Cyr61/CCN1), connective tissue growth factor (CTGF/CCN2) and vascular endothelial growth factor (VEGF) in the vascular process of polymyositis (PM)/dermatomyositis (DM).Real-time quantitative polymerase chain reaction was used to determine the mRNA expression of Cyr61, CTGF, and VEGF in muscle tissues of initially treated PM/DM patients and controls. Enzyme-linked immunosorbent assay (ELISA) was used to determine the serum levels of Cyr61, CTGF, and VEGF of initially treated PM/DM patients before and after treatment. Data were statistically analyzed using statistical software SPSS 17.0.The mRNA expression levels of Cyr61, CTGF, and VEGF in muscle tissues were higher in the PM and DM groups than in the control group (P < .05). Differences in the mRNA expression levels of Cyr61, CTGF, and VEGF in muscle tissues between the PM and DM groups were not statistically significant (P > .05). Before treatment, the serum levels of Cyr61, CTGF, and VEGF were higher in the PM and DM groups than in the control group (P < .05). Furthermore, in the PM and DM groups, the expression levels of Cyr61, CTGF, and VEGF in serum at 6 months after treatment were lower than those before treatment (P < .05).Cyr61, CTGF, and VEGF are involved in the pathogenesis of PM/DM. These may be involved in the pathogenesis mainly by affecting the formation of blood vessels and promoting inflammatory response. This suggests that microvascular lesions play an important role in the immune pathogenesis of inflammatory myopathy PM/DM.

show abstract

“…2017; Dong et al, 2018). More recent studies showed that epsins are involved in regulating Notch signaling to modulate murine embryonic stem cells exit from pluripotency (Cardano et al, 2019).…”

Section: Epsin-deficient Animal Modelsmentioning

confidence: 99%

Endocytic Adaptors in Cardiovascular Disease

Cui

Dong

Wang

et al. 2020

Front. Cell Dev. Biol.

Self Cite

View full text Add to dashboard Cite

Endocytosis is the process of actively transporting materials into a cell by membrane engulfment. Traditionally, endocytosis was divided into three forms: phagocytosis (cell eating), pinocytosis (cell drinking), and the more selective receptor-mediated endocytosis (clathrin-mediated endocytosis); however, other important endocytic pathways (e.g., caveolin-dependent endocytosis) contribute to the uptake of extracellular substances. In each, the plasma membrane changes shape to allow the ingestion and internalization of materials, resulting in the formation of an intracellular vesicle. While receptor-mediated endocytosis remains the best understood pathway, mammalian cells utilize each form of endocytosis to respond to their environment. Receptor-mediated endocytosis permits the internalization of cell surface receptors and their ligands through a complex membrane invagination process that is facilitated by clathrin and adaptor proteins. Internalized vesicles containing these receptor-ligand cargoes fuse with early endosomes, which can then be recycled back to the plasma membrane, delivered to other cellular compartments, or destined for degradation by fusing with lysosomes. These intracellular fates are largely determined by the interaction of specific cargoes with adaptor proteins, such as the epsins, disabled-homolog 2 (Dab2), the stonin proteins, epidermal growth factor receptor substrate 15, and adaptor protein 2 (AP-2). In this review, we focus on the role of epsins and Dab2 in controlling these sorting processes in the context of cardiovascular disease. In particular, we will focus on the function of epsins and Dab2 in inflammation, cholesterol metabolism, and their fundamental contribution to atherogenicity.

show abstract

Therapeutic efficacy of a synthetic epsin mimetic peptide in glioma tumor model: uncovering multiple mechanisms beyond the VEGF-associated tumor angiogenesis

Cited by 7 publications

References 29 publications

Endocytic Adaptor Proteins in Health and Disease: Lessons from Model Organisms and Human Mutations

Endocytic Adaptor Proteins in Health and Disease: Lessons from Model Organisms and Human Mutations

Strobe

Endocytic Adaptors in Cardiovascular Disease

Contact Info

Product

Resources

About