Therapeutic efficacy of different brands of albendazole against soil transmitted helminths among students of Mendera Elementary School, Jimma, Southwest Ethiopia

Tefera, Ephrem; Belay, Tariku; Mekonnen, Seleshi Kebede; Zeynudin, Ahmed; Belachew, Tefera

doi:10.11604/pamj.2015.22.252.6501

Cited by 13 publications

(14 citation statements)

References 16 publications

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“…We evaluated 44 studies with an average Jadad score of 2.5 and a total of 7273 participants positive for A lumbricoides (table N in appendix 2 gives detailed numbers) to evaluate the effect of the four anthelmintic drugs against A lumbricoides (fig 1 ). Pooled estimates were based on 19 studies with only one treatment, 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 22 studies with two treatments, 12 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 and three studies with three eligible treatments. 64 65 66…”

Section: Resultsmentioning

confidence: 99%

“…For estimating the drug efficacy against hookworm, we looked at data from 7178 individuals from 38 studies (table 1 ; table N in appendix 2) with an average Jadad score of 2.8. Pooled estimates included 12 studies with one treatment, 25 26 30 31 32 34 36 38 42 43 68 21 studies with two treatments, 12 43 44 46 47 48 49 50 51 52 53 54 55 56 57 58 62 63 68 69 70 and five studies with three treatments. 64 65 66 71 72 …”

Section: Resultsmentioning

confidence: 99%

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Efficacy of recommended drugs against soil transmitted helminths: systematic review and network meta-analysis

Moser

Schindler

Keiser

2017

BMJ

267

249

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Objective To evaluate efficacies of anthelmintic drugs against soil transmitted helminths in terms of cure rates and egg reduction rates. Design Systematic review and network meta-analysis. Data Sources PubMed, ISI Web of Science, Embase, ScienceDirect, the Cochrane Central Register of Clinical Trials, and the World Health Organization library database from 1960 until 31 December 2016. Study selection Randomised controlled trials evaluating the efficacy of a single dose regimen of albendazole, mebendazole, levamisole, and pyrantel pamoate against Ascaris lumbricoides, hookworm (Necator americanus and Ancylostoma duodenale) and Trichuris trichiura. The primary outcomes included cure rates analysed by network meta-analysis with mixed logistic regression models and egg reduction rates with mixed linear models. Results 55 and 46 randomised controlled trials were included in the analysis of cure rates and egg reduction rates, respectively. All drugs were highly efficacious against A lumbricoides. Albendazole showed the highest efficacy against hookworm infections with a cure rate of 79.5% (95% confidence interval 71.5% to 85.6%) and an egg reduction rate of 89.6% (81.9% to 97.3%). All drugs had low efficacy against T trichiura, with mebendazole showing the highest cure rate of 42.1% (25.9% to 60.2%) and egg reduction rate of 66.0% (54.6% to 77.3%). Estimates for the years 1995 and 2015 showed significant reductions in efficacy of albendazole against T trichiura: by 2015 the egg reduction rates fell from 72.6% (53.7% to 91.5%) to 43.4% (23.5% to 63.3%; P=0.049) and the cure rates fell from 38.6% (26.2% to 52.7%) to 16.4 (7.7% to 31.3%; P=0.027). Conclusions All four currently recommended drugs show limitations in their efficacy profile. While only albendazole showed good efficacy against hookworm infection, all drugs had low efficacy against T trichiura. The decrease in efficacy of albendazole against T trichiura over the past two decades is of concern. The findings indicate the need for strengthening efforts to develop new drug treatments, with a particular focus on drugs against T trichiura.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Efficacy of recommended drugs against soil transmitted helminths: systematic review and network meta-analysis

Moser

Schindler

Keiser

2017

BMJ

267

249

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“…Respondents from sixty different households were selected using a systematic random sampling design in three different villages. The first household was selected randomly using the lottery method described in Tefera et al 24 , and thereafter every third household along a road or…”

Section: Ethical Considerationsmentioning

confidence: 99%

“…All the three ailments viz. lethargy, anaemia and appetite loss managed with most of plants are classified as nutritional disorders by Cook 24 . Most plants are used to manage more than one disease.…”

Section: Common Ailment Categories Managed By Plant Species Among Prementioning

confidence: 99%

Medicinal Plants used during Antenatal Care by Pregnant Women in Eastern Uganda

Nalumansi

Kamatenesi‐Mugisha

Anywar

2017

Afr J Reprod Health

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Plants are commonly used during the antenatal stage in pregnancy to manage different ailments in Africa. In Uganda, both medicinal and food plants are used to handle common pregnancy related conditions. An ethnobotanical survey was conducted in Iganga district, eastern Uganda. Seven traditional birth attendants (TBA) and 46 mothers were interviewed. Data was collected using structured questionnaires and household interviews. The TBAs were identified using snowball sampling. A total of 33 plant species, belonging to 23 families were documented. Out of these, the pregnant mothers used 45.5 % as both food and medicine. The most frequently used plant life form was herbs (58.8%). The leaves are the most commonly used plant parts (59%). Most of the plants (58.8%) were semi cultivated and were being domesticated in crop fields and home gardens. Most of the plants were used to manage anaemia and for child development and good health among the pregnant women. The pregnant women and TBAs in Namungalwe sub County have diverse knowledge on medicinal and nutri-medicinal plants in the management of common pregnancy related diseases, which can be used to supplement modern antenatal services, inspite of the ban of the activities of TBA. Further research on the bioavailability of nutrients, efficacy and safety of the medicinal plants used by pregnant women should be done. RésuméLes plantes sont couramment utilisées pendant le stade prénatal pendant la grossesse pour gérer les différentes maladies en Afrique. En Ouganda, les plantes médicinales et alimentaires sont utilisées pour traiter des conditions courantes liées à la grossesse et pour compléter les services de soins prénatals modernes. Une enquête ethnobotanique a été menée dans le district d'Iganga, dans l'est de l'Ouganda. Sept accoucheuses traditionnelles (AT) et 46 mères ont été interviewées. Les données ont été recueillies à l'aide des questionnaires structurés et d'entrevues auprès des ménages. Les AT ont été identifiées en utilisant un échantillonnage en boule de neige. Un total de 33 espèces végétales appartenant à 23 familles ont été documentées. Parmi cellesci, les femmes enceintes consommaient 45,5% de nourriture et des médicaments. La forme de vie végétale la plus fréquemment utilisée était les herbes (58,8%). Les feuilles sont les parties de plantes les plus utilisées (59%). La plupart des plantes (58,8%) étaient semi-cultivées et étaient domestiquées dans les champs cultivés et dans les jardins potagers. La plupart des plantes étaient utilisées pour gérer l'anémie et pour le développement de l'enfant et une bonne santé chez les femmes enceintes. Les femmes enceintes et les accoucheuses traditionnelles dans le sous-comté de Namungalwe avaient des connaissances diverses sur les plantes médicinales et nutri-médicinales dans la prise en charge des maladies courantes liées à la grossesse, qui peuvent être utilisées pour compléter les services prénataux modernes. (Afr J Reprod Health 2017; 21[4]: 33-44).

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“…This risk reduction might be related to the improved sanitation, access to better water supply, improved personnel hygiene or the higher e cacy of the available treatments against A lumbricoides [115]. In support of this, a local study conducted on the e cacy of albendazole and mebendazole indicated that the drugs have 95% e cacy in decreasing the burden of the parasite in Ethiopia [125].…”

Section: Discussionmentioning

confidence: 99%

A Systematic Review and Metanalyis of Soil Transmitted Helminths Infections Among Preschool and School-age Children in Ethiopia: Evaluation of Neglected Tropica Diseases (NTDS) Elimination Program by 2020

Chelkeba¹,

Melaku²,

Emana³

et al. 2020

Preprint

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Background: Comprehensive nationwide on prevalence, geographic distribution of different species and time trends of soil-transmitted helminths (STHs) are lacking. Therefore, the aim of this study was to provide a summary and location of the available data on STHs infection among preschool and school-age children in Ethiopia. Methods: The search were carried out in Medline via PubMed, Scopus, Science Direct, Web of Science and Google Scholar on data published between 1995 to Fabruary 2020 for studies describing rate of STHs infection among preschool and school-age in Ethiopian. We followed Patient, intervention, Comparsion and Outcome (PICO) approach to identify the studies. Endnote citation manager software version X9 for Windows was utilized to collect and organize search outcomes (into relevant and irrelevant studies) and for removal duplicate articles . We conducted meta-regression to understand the trends and the source of heterogeneity and pooled the prevalence using ‘metaprop’ command using STATA software version 14.Results: A total of 29,311 of the 61,690 children examined during the period under review were infected with one or more species of intestinal parasites yielding an overall prevalence of 48 % (95%CI: 43-53%). The overall pooled estimate of STHs was 33% (95% CI: 28-38%). The prevalence was 44% (95%CI : 31% - 58%) in SNNPR, 34%((95%CI : 28% - 41%) in Amhara region, 31% (95%CI : 19% - 43%) in Oromia region and 10% (95%CI : 7% - 12%) in Tigray region. Soil-transmitted helminths infection rate has been decreasing from 44% (95% CI:30-57%) pre-Mass Drug Administration (MDA) era (1997-2012) to 30% (95% CI:25-34%) post-MDA (2013-2020), although statistically not significant (p = 0.45). A. lumbricoides was the predominant species with a prevalence of 17%. Conclusion: Southern Nations Nationalities and Peoples Region , Amhara and Oromia regions carry the highest burden and are categorized to Moderate Risk Zones (MRZ) and therefore, requiring mass drug administration (MDA) once annually with Albendazole or Mebendazole. Prevalence of SHTs decreased after MDA compared to before MDA, but the decline was not statistically significant. A. lumbricoides was the predominant species of STHs among preschool and school-age children in Ethiopia.

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Therapeutic efficacy of different brands of albendazole against soil transmitted helminths among students of Mendera Elementary School, Jimma, Southwest Ethiopia

Cited by 13 publications

References 16 publications

Efficacy of recommended drugs against soil transmitted helminths: systematic review and network meta-analysis

Efficacy of recommended drugs against soil transmitted helminths: systematic review and network meta-analysis

Medicinal Plants used during Antenatal Care by Pregnant Women in Eastern Uganda

A Systematic Review and Metanalyis of Soil Transmitted Helminths Infections Among Preschool and School-age Children in Ethiopia: Evaluation of Neglected Tropica Diseases (NTDS) Elimination Program by 2020

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