Therapeutic efficacy of eprinomectin extended-release injection against induced infections of developing (fourth-stage larvae) and adult nematode parasites of cattle

Abstract

The therapeutic efficacy of eprinomectin in an extended-release injection (ERI) formulation was evaluated against induced infections of developing fourth-stage larval or adult gastrointestinal and pulmonary nematodes of cattle in a series of six studies under two identical protocols (three each for developing fourth-stage larvae or adults) conducted in the USA, Germany or the UK (two studies at each location, one per stage). Each study initially included 16 nematode-free cattle. The cattle were of various breeds or crosses, weighed 109-186.5 kg prior to treatment, and were approximately 4-7 months old. The animals were blocked based on pre-treatment bodyweight and then randomly allocated to treatment: eprinomectin ERI vehicle (control) at 1 mL/50 kg body weight or eprinomectin 5% ERI at 1 mL/50 kg bodyweight (1.0 mg eprinomectin/kg) for a total of eight and eight animals in each group. Treatments were administered once on Day 0 by subcutaneous injection in front of the shoulder. In each study, cattle were infected with a combination of infective third-stage larvae or eggs of gastrointestinal and pulmonary nematodes. Inoculation was scheduled so that the nematodes were expected to be fourth-stage larvae or adults at the time of treatment. For parasite recovery, all study animals were humanely euthanized and necropsied 14-15 (adult infections) or 21-22 days after treatment (developing fourth-stage larval infections). When compared with the vehicle-treated control counts, efficacy of eprinomectin ERI against developing fourth-stage larvae and adults was ≥98% (p<0.05) for the following nematodes: Dictyocaulus viviparus, Bunostomum phlebotomum, Cooperia curticei, C. oncophora, C. surnabada, C. punctata, Haemonchus contortus, H. placei, Nematodirus helvetianus, Oesophagostomum radiatum, Oes. venulosum, Ostertagia leptospicularis, O. ostertagi, O. circumcincta, O. pinnata, O. trifurcata (developing fourth-stage larval infections only), Strongyloides papillosus, Trichostrongylus axei, T. colubriformis, and Trichuris ovis (adult infections only). All animals accepted the treatment well. No adverse reaction to treatments was observed in any animal in any study.

Epidemiology and control of mange in sheep and goat in menoufia governorate

“…Our results also were partially agreed with Hengge et al (2006) and Kumar and Shekhar (2010) in India who reported that using of Ivermectin resulted in complete resolution of mange crusts and scabs These results displayed in our study were partially agreed with Pourhasan et al (2013) in Ethiopia, who found that the permethrin had the ability to kill mites and its eggs, however, the combination of permethrin with other acaricides was imported to overcome drug resistance development. Our results also were consistent with Rehbein et al (2013) in Ethiopia, who mentioned that injections of ivermectin were highly effective against mites. Nevertheless, Our findings were in approximated with Desoky (2015) in Egypt, who concluded that ivermectin injection was considered the best method to control scabies in animals.…”

Efficacy of Eprin® endectocide for use in cattle against nematodes and arthropod parasites

“…) та легень (Dictyocaulus viviparus) жуйних тварин. Також ЕП згубно діє на паразитних членистоногих -паразитиформних і акариформних кліщів, постійних ектопаразитів (волосоїдів, вошей), різних видів мух та гнусу [3].…”