Therapeutic efficacy of extracellular vesicles to suppress allograft rejection in preclinical kidney transplantation models: A systematic review and meta-analysis

Fang, Yitian; Bouari, Sarah; Hoogduijn, Martin J.; IJzermans, Jan N. M.; Bruin, Ron W. F. de; Minnee, Robert C.

doi:10.1016/j.trre.2022.100714

Cited by 4 publications

(2 citation statements)

References 40 publications

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“…In animal experiments, EVs are usually isolated from (3-20) × 10 6 MSCs. A cell secretes approximately 2,000 EVs and typically injects (1-1.5) × 10 9 EVs into the animal body at once [91].…”

Section: Research and Clinical Application Of Msc-evs In Sotmentioning

confidence: 99%

Mesenchymal Stem Cells and Extracellular Vesicles: Therapeutic Potential in Organ Transplantation

Pan,

Li,

et al. 2024

Stem Cells International

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At present, organ transplantation remains the most appropriate therapy for patients with end-stage organ failure. However, the field of organ transplantation is still facing many challenges, including the shortage of organ donors, graft function damage caused by organ metastasis, and antibody-mediated immune rejection. It is therefore urgently necessary to find new and effective treatment. Stem cell therapy has been regarded as a “regenerative medicine technology.” Mesenchymal stem cells (MSCs), as the most common source of cells for stem cell therapy, play an important role in regulating innate and adaptive immune responses and have been widely used in clinical trials for the treatment of autoimmune and inflammatory diseases. Increasing evidence has shown that MSCs mainly rely on paracrine pathways to exert immunomodulatory functions. In addition, mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) are the main components of paracrine substances of MSCs. Herein, an overview of the application of the function of MSCs and MSC-EVs in organ transplantation will focus on the progress reported in recent experimental and clinical findings and explore their uses for graft preconditioning and recipient immune tolerance regulation. Additionally, the limitations on the use of MSC and MSC-EVs are also discussed, covering the isolation of exosomes and preservation techniques. Finally, the opportunities and challenges for translating MSCs and MSC-EVs into clinical practice of organ transplantation are also evaluated.

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Section: Research and Clinical Application Of Msc-evs In Sotmentioning

confidence: 99%

Mesenchymal Stem Cells and Extracellular Vesicles: Therapeutic Potential in Organ Transplantation

Pan,

Li,

et al. 2024

Stem Cells International

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“…Some studies suggest that EVs have essential roles in immunization within kidney transplantation [ 63 ]. Although no clinical study has been conducted regarding the therapeutic use of EVs as a suppressor for allograft rejection, a paper recently collected and meta-analyzed the findings of preclinical models to investigate the beneficial effects of EVs in transplantation [ 64 ]. This analytical review of seven preclinical studies investigated immune cell and MSC-EVs from syngeneic and allogeneic models regarding graft survival and kidney function.…”

Section: Evs In Kidney Transplantationmentioning

confidence: 99%

Extracellular vesicles in kidney development and pediatric kidney diseases

Ergunay,

Collino,

Bianchi

et al. 2023

Pediatr Nephrol

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Extracellular vesicles (EVs) are membranous cargo particles that mediate intercellular communication. They are heterogeneous in size and mechanism of release, and found in all biological fluids. Since EV content is in relation to the originating cell type and to its physiopathological conditions, EVs are under study to understand organ physiology and pathology. In addition, EV surface cargo, or corona, can be influenced by the microenvironment, leading to the concept that EV-associated molecules can represent useful biomarkers for diseases. Recent studies also focus on the use of natural, engineered, or synthetic EVs for therapeutic purposes. This review highlights the role of EVs in kidney development, pediatric kidney diseases, including inherited disorders, and kidney transplantation. Although few studies exist, they have promising results and may guide researchers in this field. Main limitations, including the influence of age on EV analyses, are also discussed.

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Unlocking the promise of mesenchymal stem cells and extracorporeal photopheresis to address rejection and graft failure in intestinal transplant recipients

Levitte,

Nilkant,

Jensen

et al. 2024

Human Immunology

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Therapeutic efficacy of extracellular vesicles to suppress allograft rejection in preclinical kidney transplantation models: A systematic review and meta-analysis

Cited by 4 publications

References 40 publications

Mesenchymal Stem Cells and Extracellular Vesicles: Therapeutic Potential in Organ Transplantation

Mesenchymal Stem Cells and Extracellular Vesicles: Therapeutic Potential in Organ Transplantation

Extracellular vesicles in kidney development and pediatric kidney diseases

Unlocking the promise of mesenchymal stem cells and extracorporeal photopheresis to address rejection and graft failure in intestinal transplant recipients

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