Therapeutic efficacy of human umbilical cord mesenchymal stem cells transplantation against renal ischemia/reperfusion injury in rats

Stem/Stromal Cells for Treatment of Kidney Injuries With Focus on Preclinical Models

“…BM-MSC are able to reduce oxidative stress by decreasing the amount of malondialdehyde, superoxide dismutase, and glutathione peroxidase in post ischemic kidney tissue ( 232 ). A similar effect was found using hUC-MSC ( 155 ). The underlying mechanism was further investigated in a study with human Wharton's jelly (WJ)-MSC-EVs in which they found that the antioxidant effect observed was the result of the Nrf2-ARE pathway activation, which regulates the expression of antioxidant proteins ( 159 ).…”

The Efficacy of Mesenchymal Stem Cells in Therapy of Acute Kidney Injury Induced by Ischemia-Reperfusion in Animal Models

“…The databases mentioned above were searched for this meta-analysis, and we only recruited these studies in mice or rat for evaluation of therapeutic efficiency of MSC treatment on AKI. Nineteen studies [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39] were eligible and recruited for this meta-analysis, and the flowchart of inclusion of studies is presented in Figure 1. The included study characteristics are shown in Table 1.…”

“…12 studies [ 21 , 24 – 28 , 30 , 31 , 33 , 36 , 38 , 39 ] were included to assess the effect of MSCs on Scr, 7 for 1 day, 3 for 2 days, 10 for 3 days, 2 for 5 days, 2 for 7 days, and 2 for >7 days, and the results indicated that the difference between the MSC treatment group and the control group was notable for 1 day, 2 days, 3 days, and 5 days (1 day: WMD = −11.72, 95% CI: -18.80, -4.64, P = 0.001; 2 days: WMD = −33.60, 95% CI: -40.15, -27.05, P < 0.00001; 3 days: WMD = −21.14, 95% CI: -26.15, -16.14, P < 0.00001; and 5 days: WMD = −8.88, 95% CI: -11.06, -6.69, P < 0.00001; Figure 4 and Table 2 ). However, the difference between the MSC treatment group and the control group was not notable for 7 days and >7 days (7 days: WMD = −0.72, 95% CI: -13.49, -12.05, P = 0.91; >7 days: WMD = −90.84, 95% CI: -257.31, 75.62, P = 0.28; Figure 4 and Table 2 ).…”

“…Scr. 19 studies [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39] were included to assess the effect of MSCs on Scr, 12 for 1 day, four for 2 days, 14 for 3 days, four for 5 days, seven for 7 days, and five for >7 days, and the results showed that the difference between the MSC treatment group and the control group was notable for 1 day, 2 days, 3 days, 5 days, and >7 days (1 day: WMD = −0:56, 95% CI: -0.78, -0.34, P < 0:00001; 2 days: WMD = −0:58, 95% CI: -0.89, -0.28, P = 0:0002; 3 days: WMD = −0:65, 95% CI: -0.84, -0.45, P < 0:00001; 5 days: WMD = −0:35, 95% CI: -0.54, -0.16, P = 0:0003; and >7 days: WMD = −0:22, 95% CI: -0.36, -0.08, P = 0:002; Figure 3 and Table 2). However, the difference between the MSC treatment group and the control group was not notable for 7 days (WMD = −0:14, 95% CI: -0.28, -0.00, P = 0:05; Figure 3 and Table 2).…”

“…Factors. In this meta-analysis, four studies [21,24,32,39] were included for the assessment of MDA, two [24,39] for GSH, two [21,24] for CAT, two [21,39] for SOD, three [28,30,33] for NOX1, four [21,28,30,33] for NOX2, four [21,28,30,33] for PARP1, two [21,27] for Caspase 3 (mRNA), three [28,30,33] for Caspase 3 (protein), and three [28,30,33] for Bax. The results indicated that the difference between the MSC treatment group and the control group was notable Table 2).…”