2001
DOI: 10.1002/ijc.10167
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Therapeutic efficacy of IL‐2‐loaded hydrogels in a mouse tumor model

Abstract: Interleukin-2 (IL-2) is a highly effective anticancer drug if it is applied locally for 5 consecutive days. In most cases this requires 5 invasive treatments, which is not usually acceptable for either the patient or the clinician. For this reason we have developed dextran-based hydrogels from which the required amount of encapsulated IL-2 (1-4 ؋ 10 6 IU of IL-2) is gradually released during 5-10 days. Initially IL-2-containing macroscopic cylinder-shaped gels (implants), and later IL-2-containing injectable m… Show more

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Cited by 30 publications
(20 citation statements)
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“…Peptide-based hydrogels conjugated to enzymatically sensitive poly(ethylene glycol) (PEG) have been synthesized by Cu(I)-catalyzed 1,3-dipolar cycloaddition to improve peptide biocompatibility [70]. Hydrogels prepared with Cu(I)-catalyzed 1,3-dipolar cycloaddition reaction between a trypsin- and plasmin-sensitive bis-azido peptide and star-shaped alkyne derivatized PEG moieties have potential use for enzyme-triggered release of drugs at the site of tumors [71]. Parrish et al .…”
Section: Bioconjugation To Combine Units With Different Functionsmentioning
confidence: 99%
“…Peptide-based hydrogels conjugated to enzymatically sensitive poly(ethylene glycol) (PEG) have been synthesized by Cu(I)-catalyzed 1,3-dipolar cycloaddition to improve peptide biocompatibility [70]. Hydrogels prepared with Cu(I)-catalyzed 1,3-dipolar cycloaddition reaction between a trypsin- and plasmin-sensitive bis-azido peptide and star-shaped alkyne derivatized PEG moieties have potential use for enzyme-triggered release of drugs at the site of tumors [71]. Parrish et al .…”
Section: Bioconjugation To Combine Units With Different Functionsmentioning
confidence: 99%
“…Alternatively, microspheres were formed from dextran-hydroxyethylmethacrylate (dextran-HEMA), which has an ester bond that is readily hydrolyzed. Degradation of the microspheres by hydrolysis permitted release of IgG [190] or IL-2 [191]. Liposomes were also found to be efficiently encapsulated in dextran microspheres [192].…”
Section: Instructive Examples Of Liquid-liquid Two Phase Systemsmentioning
confidence: 99%
“…For example, dextran microspheres had a 98% immunoglobulin G (IgG) encapsulation efficiency when 0.22 M KCl was included in the aqueous two phase suspension to induce IgG partitioning into the dispersed phase [5354]. In a separate study, De Groot et al obtained greater than 90% encapsulation efficiencies of interleukin-2 into hydroxyethyl methacrylated dextran (HEMA-dextran) microspheres if the water content of the aqueous two phase suspension was below 70% [55]. Recently, Vlugt-Wensink et al characterized the effect of common industrial excipients on the encapsulation efficiency of human growth hormone (hGH) into HEMA-dextran microspheres during an aqueous two phase suspension polymerization process.…”
Section: Discussionmentioning
confidence: 99%