Therapeutic Efficacy of Subgingivally Delivered Doxycycline Hyclate as an Adjunct to Non-surgical Treatment of Chronic Periodontitis

Deo, Vikas; Ansari, Salman; Mandia, Sunita; Bhongade, Manohar L

doi:10.5037/jomr.2011.2103

Cited by 12 publications

(11 citation statements)

References 17 publications

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“…Thus, the removal of this biofilm before the gel application could promote greater DOX efficacy. 36 DOX concentrates on tissues, including the bone microenvironment, and also has an osteogenic effect. For these reasons, it has been used in the treatment of bone diseases.…”

Section: Discussionmentioning

confidence: 99%

Doxycycline encapsulated in β-cyclodextrin for periodontitis: a clinical trial

et al. 2019

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This clinical trial compared the efficacy of doxycycline (DOX) in β-cyclodextrin (DOX)/βCD) with DOX-alone in gel on thirty-three subjects with periodontitis. Patients were randomized to group 1 GI; 10% DOX + scaling and root planning (SRP); group 2 (GII (10% DOX /β-CD + SRP), and group 3 (GIII; SRP). Gels were applied in GI and GII at baseline (T0) and 30 days later (T1). Periodontal Probing Depth (PPD), Clinical Attachment Level (CAL), Bleeding on Probing (BOP) and Visible Plaque Index (VPI) were evaluated at (T0), 30 days (T1) and 60 days after T0 (T2). Bone density was analyzed after 18 months (T3). GII showed the most significant reduction of PPD (2.62 mm; p <0.003), and greatest gain in CAL (2.54 mm p <0.003) at T2. BOP and the VPI had a strong reduction in all groups at T2 (p <0.05), both decreased by ≥5 times and 2 times, respectively, in all groups at T1. Bone density increased in all groups in radiographs (T3). The use of DOX encapsulated in β-CD gel with SRP resulted in significant improvements in clinical periodontal parameters; such molecular inclusion of doxycycline into β-CD in gel for local application is relatively simple and useful in dentistry.

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Section: Discussionmentioning

confidence: 99%

Doxycycline encapsulated in β-cyclodextrin for periodontitis: a clinical trial

et al. 2019

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“…Three studies were multi-arm trials [ 48 , 52 , 53 ]. The adjuncts included were: (1) antimicrobial photodynamic therapy (aPDT) indocyanine green (ICG) [ 54 , 55 ], (2) aPDT methylene blue (MB) 0.005% [ 56 , 57 ], (3) aPDT MB 1% [ 47 , 58 , 59 , 60 ], (4) aPDT phenothiazine chloride (PC) [ 61 , 62 ], (5) aPDT toluidine blue O (TBO) [ 53 ], (6) chlorhexidine (CHX) chip [ 52 , 63 , 64 ], (7) CHX xanthan gel [ 65 , 66 ], (8) doxycycline hyclate (DH) gel [ 50 , 67 ], (9) metronidazole (MET) gel [ 68 , 69 ], (10) minocycline (MINO) gel [ 49 , 70 ], (11) MINO microspheres [ 48 , 71 , 72 ], (12) povidone iodine (PI) 10% irrigating solution [ 73 ], (13) sulfonic/sulfuric acid (SA) gel [ 51 ], and (14) tetracycline (TC) fibers [ 52 ]. SMD alone was used as the reference comparator arm.…”

Section: Resultsmentioning

confidence: 99%

Clinical Efficacy of Single Application Local Drug Delivery and Adjunctive Agents in Nonsurgical Periodontal Therapy: A Systematic Review and Network Meta-Analysis

2020

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This review aimed to rank the clinical efficacy of commercially available single-application local drug delivery and adjunctive agents (LDAs) compared with subgingival mechanical debridement (SMD) in nonsurgical periodontal therapy (NSPT). Randomized controlled clinical trials that compared LDAs against SMD alone or with placebo in adults (aged at least 18 years) diagnosed with periodontitis with a minimum of 6 months follow-up were included. A frequentist approach to random-effects network meta-analysis was implemented. The efficacies of the LDAs measured by probing pocket depth (PPD) reduction and clinical attachment level (CAL) gain were reported as mean difference (MD) with 95% confidence intervals (CIs). The treatments were ranked according to their P-score. Four network meta-analyses suggested that sulfonic/sulfuric acid gel (PPD MD −1.13 mm, 95% CI −1.74 to −0.53, P-score 0.91; CAL MD −1.09 mm, 95% CI −1.58 to −0.61, P-score 0.95) and doxycycline hyclate gel (PPD MD −0.90 mm, 95% CI −1.50 to −0.30, P-score 0.93; CAL MD −0.84 mm, 95% CI −1.40 to −0.28, P-score 0.92) were the most effective in reducing PPD and gaining CAL in split-mouth and parallel studies, respectively (moderate certainty of evidence). LDAs have differing efficacies, but they present with possible clinical significance over SMD alone in NSPT.

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“…Bogren et al showed that Doxycycline had statistically significant differences in clinical parameters only at 3-month examination; after 3 month period, doxycycline and mechanical debridement were effective in reducing just a minority of microbiological pathogens 23 . Deo et al reported that doxycycline hyclate 10% as an adjunct to SRP provided significant reductions in PPD and gains in CAL compared to SRP alone 24 .…”

Section: Ointment:-mentioning

confidence: 99%