Therapeutic efficacy of topical blockade of substance P in experimental allergic red eye

Wang, Shudan; Liu, Lingjia; Blanco, Tomás; Ge, Hongyan; Xia, Yutong; Pang, Kunpeng; Chen, Yihe; Dana, Reza

doi:10.1016/j.jtos.2022.08.008

Cited by 6 publications

(2 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, HR1, alongside BK2R, contributes to increased vascular permeability [83,84]. Furthermore, NKR1 antagonists alleviate similar symptoms and reduce allergy-induced ocular redness and eosinophilic infiltration [29,85,86], benefits that traditional antihistamines fail to achieve. Finally, CLR1 as an NKR1 antagonist also influences eosinophilic proliferation and accumulation and type 2 innate lymphoid cell activity, both of which are strongly linked to rhinosinusitis [87,88].…”

Section: Ud Phytochemicals' Effects On Sensorial Nerves and Immune Cellsmentioning

confidence: 99%

Evaluation of Urtica dioica Phytochemicals against Therapeutic Targets of Allergic Rhinitis Using Computational Studies

Culhuac,

Bello

2024

Molecules

View full text Add to dashboard Cite

Allergic rhinitis (AR) is a prevalent inflammatory condition affecting millions globally, with current treatments often associated with significant side effects. To seek safer and more effective alternatives, natural sources like Urtica dioica (UD) are being explored. However, UD’s mechanism of action remains unknown. Therefore, to elucidate it, we conducted an in silico evaluation of UD phytochemicals’ effects on known therapeutic targets of allergic rhinitis: histamine receptor 1 (HR1), neurokinin 1 receptor (NK1R), cysteinyl leukotriene receptor 1 (CLR1), chemoattractant receptor-homologous molecule expressed on type 2 helper T cells (CRTH2), and bradykinin receptor type 2 (BK2R). The docking analysis identified amentoflavone, alpha-tocotrienol, neoxanthin, and isorhamnetin 3-O-rutinoside as possessing a high affinity for all the receptors. Subsequently, molecular dynamics (MD) simulations were used to analyze the key interactions; the free energy of binding was calculated through Generalized Born and Surface Area Solvation (MMGBSA), and the conformational changes were evaluated. Alpha-tocotrienol exhibited a high affinity while also inducing positive conformational changes across all targets. Amentoflavone primarily affected CRTH2, neoxanthin targeted NK1R, CRTH2, and BK2R, and isorhamnetin-3-O-rutinoside acted on NK1R. These findings suggest UD’s potential to treat AR symptoms by inhibiting these targets. Notably, alpha-tocotrienol emerges as a promising multi-target inhibitor. Further in vivo and in vitro studies are needed for validation.

show abstract

Section: Ud Phytochemicals' Effects On Sensorial Nerves and Immune Cellsmentioning

confidence: 99%

Evaluation of Urtica dioica Phytochemicals against Therapeutic Targets of Allergic Rhinitis Using Computational Studies

Culhuac,

Bello

2024

Molecules

View full text Add to dashboard Cite

show abstract

“…Finally, the expression of pro-inflammatory cytokines was decreased by topical administration of L-703606 in the conjunctiva. However, the effect of the NK1R antagonist on corneal epithelium remains elusive in the study [132].…”

Section: Nk1r and Ocular Inflammationmentioning

confidence: 99%

The NK-1 Receptor Signaling: Distribution and Functional Relevance in the Eye

Demirsoy

Ferrari

2022

Receptors

View full text Add to dashboard Cite

Neurokinin-1 receptor (NK1R) signaling pathways play a crucial role in a number of biological processes in the eye. Specifically, in the ocular surface, their activity modulates epithelial integrity, inflammation, and generation of pain, while they have a role in visual processing in the retina. The NK1R is broadly expressed in the eye, in both ocular and non-ocular cells, such as leukocytes and neurons. In this review, we will discuss the roles of neurokinin-1 receptors and substance P (SP) in the physiopathology of eye disorders. Finally, we will review and highlight the therapeutic benefits of NK1R antagonists in the treatment of ocular diseases.

show abstract

The ratio of alpha-calcitonin gene-related peptide to substance P is associated with the transition of bone metabolic states during aging and healing

Liu,

Yu,

Liao

et al. 2023

J Mol Histol

View full text Add to dashboard Cite

Therapeutic efficacy of topical blockade of substance P in experimental allergic red eye

Cited by 6 publications

References 40 publications

Evaluation of Urtica dioica Phytochemicals against Therapeutic Targets of Allergic Rhinitis Using Computational Studies

Evaluation of Urtica dioica Phytochemicals against Therapeutic Targets of Allergic Rhinitis Using Computational Studies

The NK-1 Receptor Signaling: Distribution and Functional Relevance in the Eye

The ratio of alpha-calcitonin gene-related peptide to substance P is associated with the transition of bone metabolic states during aging and healing

Contact Info

Product

Resources

About