Therapeutic exercise for people with amyotrophic lateral sclerosis or motor neuron disease

Bello-Haas, Vanina Dal; Florence, Julaine; Krivickas, Lisa S.

doi:10.1002/14651858.cd005229.pub2

Cited by 65 publications

(71 citation statements)

References 33 publications

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“…One random controlled study determined improvement based on increased total ALS Functional Rating Scale as well as increases in upper and lower limb functionality and has been corroborated by studies undertaken in Canada. [135][136][137] This is a promising area of study that will hopefully be developed more fully in the future.…”

Section: Resistance Exercisementioning

confidence: 99%

Cross-Sectional Survey of Relevant Literatures as to the Current Proposed Disease Mechanisms and Treatments of Amyotrophic Lateral Sclerosis (ALS)

Sanford¹

2015

MJM

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Section: Resistance Exercisementioning

confidence: 99%

Cross-Sectional Survey of Relevant Literatures as to the Current Proposed Disease Mechanisms and Treatments of Amyotrophic Lateral Sclerosis (ALS)

Sanford¹

2015

MJM

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“…Regular moderate physical exercise can increase the production of endogenous growth factors, as well as the delivery and utilization of exogenous growth factors. It has been proved that physical exercise is beneficial in animal experiments [59-62] and human clinic trails [63-67] although controversy still exists based on exercise intensity [61, 67, 68], age and sexual differences.…”

Section: Growth Factor Therapy For Alsmentioning

confidence: 99%

Neuroprotection for Amyotrophic Lateral Sclerosis: Role of Stem Cells, Growth Factors, and Gene Therapy

2012

CNSAMC

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Various molecular mechanisms including apoptosis, inflammation, oxidative stress, and excitotoxicity have been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS), though the exact mechanisms have yet to be specified. Furthermore, the underlying restorative molecular mechanisms resulting in neuronal and/or non-neuronal regeneration have to be yet elucidated. Therapeutic agents targeting one or more of these mechanisms to combat either initiation or progression of the disease are under research. Novel treatments including stem cell therapy, growth factors, and gene therapy might prolong survival and delay progression of symptoms. Harnessing the regenerative potential of the central nervous system would be a novel approach for the treatment of motor neuron death resulting from ALS. Endogenous neural replacement, if augmented with administration of exogenous growth factors or with pharmaceuticals that increase the rate of neural progenitor formation, neural migration, and neural maturation could slow the rate of cell loss enough to result in clinical improvement. In this review, we discuss the impact of therapeutic treatment involving stem cell therapy, trophic factors, gene therapy, and combination therapy on disease onset and progression of ALS. In addition, we summarize human clinical trials of stem cell therapy, growth factor therapy, and gene therapy in individuals with ALS.

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“…Experimental data [5][6][7] and several randomised trials showed moderate effects and benefits of submaximal resistive exercises especially in early stages of the disease [8,9].…”

Section: Introductionmentioning

confidence: 97%

“…Excessive or high resistant exercises have been associated with overwork damage and thus are not recommended in ALS [8]. The key focus for physical therapists is to delay the decline of muscular strength by submaximal resistance exercise, which has been shown to be safe and efficacious.…”

Section: Introductionmentioning

confidence: 99%

Patient-Reported Outcome of Physical Therapy in Amyotrophic Lateral Sclerosis: Observational Online Study (Preprint)

Meyer¹,

Spittel²,

Steinfurth³

et al. 2018

Preprint

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Therapeutic exercise for people with amyotrophic lateral sclerosis or motor neuron disease

Cited by 65 publications

References 33 publications

Cross-Sectional Survey of Relevant Literatures as to the Current Proposed Disease Mechanisms and Treatments of Amyotrophic Lateral Sclerosis (ALS)

Cross-Sectional Survey of Relevant Literatures as to the Current Proposed Disease Mechanisms and Treatments of Amyotrophic Lateral Sclerosis (ALS)

Neuroprotection for Amyotrophic Lateral Sclerosis: Role of Stem Cells, Growth Factors, and Gene Therapy

Patient-Reported Outcome of Physical Therapy in Amyotrophic Lateral Sclerosis: Observational Online Study (Preprint)

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