Therapeutic Experience with Lithium in Childhood Aggressivity

Vetró, Ágnes; Szentistványi, I.; Pallag, L; Vargha, Márta; Szilárd, J.

doi:10.1159/000118217

Cited by 18 publications

(2 citation statements)

References 22 publications

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“…Lithium carbonate, an alkali metal that enhances serotonergic activity in the brain has also yielded mixed results in studies on its efficacy in the treatment of children and adolescents with CD. Some studies reported low to high success rates in treating CD in children with lithium carbonate (e.g., Campbell et aI., 1984;Malone, Luebert, Pena-Ariet, Biesecker, & Delaney, 1994;Vetro, Szentistvanyi, Pallag, & Szilard, 1985). Treatment of CD in children with lithium carbonate was also associated with non-impairment of cognitive functions (Platt, Campbell, Green, & Grega, 1984).…”

Section: Neuroleptics and CDmentioning

confidence: 99%

Psychopharmacology in the Treatment of Conduct Disorder Children and Adolescents: Rationale, Prospects, and Ethics

Mpofu

2002

South African Journal of Psychology

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The rationale for psychopharmacological treatments of conduct disorder (CD) in children and adolescent is discussed with reference to the presumed neurophysiological basis of the disorder. Specific psychopharmacological treatments for children with CD are identified and briefly evaluated in terms of their empirical foundations. The lack of a secure knowledge base on the biochemical basis of CD and the efficacy of psychopharmacological treatments with children and adolescents suggests the need for caution in the wide use of pharmacotherapy with these populations. Psychopharmacological treatments with children and adolescents with CD are particularly indicated for reactive aggression, and CD with comordid conditions. Conceptual and methodological improvements in use of psychotropic medications with children and adolescents are discussed as well as the associated ethical considerations.

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Section: Neuroleptics and CDmentioning

confidence: 99%

Psychopharmacology in the Treatment of Conduct Disorder Children and Adolescents: Rationale, Prospects, and Ethics

Mpofu

2002

South African Journal of Psychology

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“…There is a growing number of case reports and open trials suggesting that lithium may be an effective treatment for aggressive behavior in children and adolescents (e.g. DeLong & Aldershof, 1987;Vetro, Szentistvanyi, Pallag, Vargha & Szilard, 1985), but controlled studies are limited. Campbell et ai (1984) found lithium to be highly superior to placebo in suppressing aggressive behavior in hospitalized prepubertal children with conduct disorder.…”

Section: Efficacy Aggressionmentioning

confidence: 99%

Pediatric Psychopharmacotherapy: A Review of Recent Research

Gadow

1992

Child Psychology Psychiatry

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In the past 5 years, we have witnessed the continuation of important trends in clinical research that began earlier in the decade. With regard to the treatment of specific disorders in children and adolescents, the most significant developments have been the examination of the tricyclics for the treatment of depression and the initiation of controlled studies for the treatment of Tourette syndrome. Unfortunately, the findings from the depression studies have been uniformly negative, and the results of research on both depression and tic disorders show a relatively high rate of placebo responsivity, which raises nagging questions about the role of case reports and open trials. Another important trend in pediatric psychopharmacotherapy is the search for substitutes for the neuroleptics. Potential candidates include agents such as lithium, naltrexone, fenfluramine, clonidine, and carbamazepine. The most underresearched disorders are a combination of the least common (e.g. schizophrenia, mania) and those that are apparently perceived as less serious (e.g. sleep disorders, certain anxiety disorders). Not surprisingly, the most studied disorder and treatment is hyperactivity and stimulant medication, respectively. Considerable progress has been made in understanding the social implications of the associated symptoms and their response to stimulant drugs, aided greatly by the use of direct observation procedures. Researchers are beginning to attend to the implications of comorbidity for assessing response to medication. There has been additional confirmation of efficacy of stimulant treatment for preschoolers and adolescents. Dose-response issues remain to some extent unresolved, the primary impediments being interpretive misconceptions associated with trend analysis, an overreliance on the syndromal perspective and too little attention to target behaviors and their clinical implications, and the failure to operationalize the minimal effective dose with regard to the normalization and supranormalization of target and collateral behaviors. Disagreement over whether hyperactivity is a learning or a behavior disorder (or both) and what academic underproductivity means clinically and socially is also impeding progress. With regard to developmental disorders, controlled studies indicate that fenfluramine and naltrexone are effective for managing associated symptoms in some individuals. However, given the limited amount of research on these agents, their status as clinically useful palliatives must be considered tentative.(ABSTRACT TRUNCATED AT 400 WORDS)

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A guide to the literature on aggressive behavior

1986

Aggr. Behav.

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Therapeutic Experience with Lithium in Childhood Aggressivity

Cited by 18 publications

References 22 publications

Psychopharmacology in the Treatment of Conduct Disorder Children and Adolescents: Rationale, Prospects, and Ethics

Psychopharmacology in the Treatment of Conduct Disorder Children and Adolescents: Rationale, Prospects, and Ethics

Pediatric Psychopharmacotherapy: A Review of Recent Research

A guide to the literature on aggressive behavior

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