Therapeutic goals and treatment options for prevention of stress ulcer syndrome

Comparison of three acute stress models for simulating the pathophysiology of stress-related mucosal disease

“…SRMD is a considerable reason of morbidity in addition to mortality in critically ill patients in ICU (4). Upper gastrointestinal (GI) bleeding observed in SRMD patients places critically ill patients at a high risk of death (5,6). SRMD in the ICU patients also adds to the cost of treatment by increasing the stay of patients at the hospital (2,7).…”

Gastroprotective effects of Pikad Tri-phol-sa-mut-than herbal remedy on multiple gastric ulcer models in rats

“…It has been reported that stress-induced gastric ulceration is associated with mortality [ 42 , 43 ]. Restrain water immersion stress-induced gastric ulcer is a model widely used for investigating drugs that can be used to treat diseases related to stress [ 44 , 45 ]. Stress-induced gastric ulcer is related to vagal overactivity, oxidative stress and free radical generation, and the decrease of gastric mucosal blood flow, resulting in gastric ulcer formation [ 42 , 46 , 47 ].…”

Stress Ulcer Prophylaxis: Still a Valid Option in the 1990s?

“…and a drop in the hemoglo bin concentration might be due to any extragastrointestinal bleeding source. Antisecretory drugs and antacids, but not sucralfate, prevent acid denaturation of hemoglobin and thus increase the sensitivity of the guaiac test, which may even yield false-positive results [11][12][13] In patients experiencing stress bleeding, mortality is estimated to range between 35 and 77% even in recent studies [15,16]. The mortality of bleeding intensive-care patients is significantly higher than in nonbleeding pa tients [17], Thus, prevention of stress bleeding might reduce the mortality.…”